Results 121 to 130 of about 12,205 (240)

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

Citrullination of HP1γ chromodomain affects association with chromatin

Epigenetics & Chromatin, 2019
Background Stem cell differentiation involves major chromatin reorganisation, heterochromatin formation and genomic relocalisation of structural proteins, including heterochromatin protein 1 gamma (HP1γ). As the principal reader of the repressive histone
Meike Wiese, Andrew J. Bannister, Srinjan Basu, Wayne Boucher, Kai Wohlfahrt, Maria A. Christophorou, Michael L. Nielsen, David Klenerman, Ernest D. Laue, Tony Kouzarides   +9 more
doaj   +1 more source

pH/Acetonitrile-Gradient Reversed-Phase Fractionation of Enriched Hyper-Citrullinated Library in Combination with LC-MS/MS Analysis for Confident Identification of Citrullinated Peptides. [PDF]

Methods Mol Biol, 2022
Stachowicz A, Sundararaman N, Venkatraman V, Van Eyk J, Fert-Bober J.   +4 more
europepmc   +1 more source

Earthworm coelomocyte extracellular traps : structural and functional similarities with neutrophil NETs [PDF]

, 2018
ROD UJ /
Joanna Homa
core   +2 more sources

[Antibodies to cyclic citrullinized peptide in rheumatoid arthritis].

Terapevticheskii arkhiv, 2004
To estimate a diagnostic value of antibodies to cyclic citrullinized peptide (CCP) in rheumatoid arthritis (RA).The study was made of 85 RA patients. Of them, 48 patients had early RA, i.e. of 8 month and less duration. The control group consisted of 35 patients with non-differentiated arthritis (NDA) and 8 healthy donors.
E N Aleksandrova, N A Chemeris, D E Karateev, A A Novikov, K A Brodetskaya, E L Nasonov   +5 more
openaire   +2 more sources

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, EarlyView.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

Factor reumatoideo, anticuerpos antipéptidos citrulinados y actividad de la enfermedad en pacientes con artritis reumatoidea

Revista Habanera de Ciencias Médicas, 2015
Introducción: la artritis reumatoidea es una enfermedad inflamatoria crónica y multisistémica de causa autoinmune.Los anticuerpos antipéptidos citrulinados constituyen una herramienta importante para el diagnóstico de esta enfermedad.
Goitybell Martínez Téllez, Jorge Alexis Gómez, Vicky Sánchez Rodríguez, Cira Rodríguez Pelier, Bárbara Torres Rives, Ana María Torres Lima   +5 more
doaj  

Long‐term remission of type B insulin resistance syndrome with immunotherapy: A case report

Journal of Diabetes Investigation, EarlyView.
ABSTRACT We report long‐term remission in a patient with type B insulin resistance achieved with a combination of immunotherapies. A 55‐year‐old Japanese man presented with nocturnal hypoglycemia and cytopenia. He also had postprandial hyperglycemia due to severe insulin resistance, which was difficult to manage using high‐dose insulin and recombinant ...
Erika Egawa, Rei Karasawa, Yuka Kageyama, Kazuhiko Takaya   +3 more
wiley   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source