Results 131 to 140 of about 14,198 (253)

Dendritic cells and the promise of antigen-specific therapy in rheumatoid arthritis [PDF]

, 2013
Rheumatoid arthritis (RA) is a systemic inflammatory disease resulting from an autoimmune response to self-antigens, leading to infl ammation of synovial tissue of joints and subsequent cartilage and bone erosion. Current disease-modifying anti-rheumatic
Thomas, Ranjeny
core   +2 more sources

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis [PDF]

, 2013
Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA)- DRB1 locus that possesses the shared susceptibility epitope (SE) and the citrullination of self-antigens.
Abadie, Aletaha, Anthony W. Purcell, Aricescu, Bailey, Bharadwaj, Bongartz, Broughton, Brömme, Colaert, Dessen, Dudek, Foulquier, Gregersen, Hammer, Hammer, Harre, Helmick, Henderson, Hendrik J. Nel, Hill, Hill, Hsieh, Hugh H. Reid, Huizinga, Illing, James McCluskey, Jamie Rossjohn, Jan Petersen, Jones, Jurgen van Heemst, Khai Lee Loh, Klareskog, Klareskog, Kuhn, Lakshmi C. Wijeyewickrema, Law, Li, Lundberg, Makrygiannakis, Mallone, Mannering, Miyara, Miyara, Nadine L. Dudek, Nicole L. La Gruta, Padyukov, Pang, Petersen, Pettit, Ranjeny Thomas, Raychaudhuri, Reeves, Rene E. Toes, Robert N. Pike, Scarsi, Schönland, Sempere-Ortells, Sette, Sidonia B.G. Eckle, Snir, Soi Cheng Law, Stephen W. Scally, Su, Tung, van der Woude, van Gaalen, Viatte, von Delwig, Vossenaar, Vossenaar, Wegner   +71 more
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Autoantibodies to citrullinated proteins: ACPA

Autoimmunity, 2005
Anti-perinuclear factor and anti-keratin antibodies have long been known to be specifically associated with rheumatoid arthritis (RA). They were first demonstrated to target various forms of (pro)filaggrin, a protein of stratified epithelia. Then, they were found to belong to a single family of autoantibodies targeting proteins that bear peptidic ...
Christian, Vincent, Leonor, Nogueira, Cyril, Clavel, Mireille, Sebbag, Guy, Serre   +4 more
openaire   +2 more sources

Estrogen induces global reorganization of chromatin structure in human breast cancer cells [PDF]

, 2014
In the cell nucleus, each chromosome is confined to a chromosome territory. This spatial organization of chromosomes plays a crucial role in gene regulation and genome stability.
Hsu, Pei-Yin, Huang, Tim H., Juran, Liran, Koneru, Prasad, Li, Lang, Lin, Hai, Liu, Yunlong, Mourad, Raphael, Nephew, Kenneth, Shen, Changyu   +9 more
core   +3 more sources

In wound repair vimentin mediates the transition of mesenchymal leader cells to a myofibroblast phenotype. [PDF]

, 2018
Following injury, mesenchymal repair cells are activated to function as leader cells that modulate wound healing. These cells have the potential to differentiate to myofibroblasts, resulting in fibrosis and scarring.
Alnwibit, A. A., Bleaken, B. M., Menko, A. S., Romisher, A. R., Walker, J. L.   +4 more
core   +1 more source

Processing of proteins in autophagy vesicles of antigen-presenting cells generates citrullinated peptides recognized by the immune system [PDF]

, 2012
Our laboratory has been investigating for some time the nature of the response of T lymphocytes in autoimmunity in the reactions against self-proteins that result in a number of diseases, such as type 1 diabetes, multiple sclerosis, rheumatoid arthritis (
Ireland, Jamie M, Unanue, Emil R
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ACPAs Are Much More Than Diagnostic Autoantibodies

Rambam Maimonides Medical Journal, 2016
Anti-citrullinated protein autoantibodies (ACPAs) are the major autoantibodies in rheumatoid arthritis (RA). Anti-citrullinated protein autoantibodies are directed against different citrullinated antigens, including filaggrin, fibrinogen, vimentin, and ...
Abdulla Watad, Howard Amital
doaj   +1 more source

Citrullination of Epithelial Neutrophil–Activating Peptide 78/CXCL5 Results in Conversion From a Non–Monocyte‐Recruiting Chemokine to a Monocyte‐Recruiting Chemokine [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/108594/1/art38750 ...
Akahoshi, Browning, Chang, Chapman, Fan, Foulquier, Gerszten, Halloran, Haringman, Hatano, Holmes, Horuk, Kinloch, Koch, Koch, Koch, Koch, Koch, Korchynskyi, Kubota, Liddiard, Loos, Loos, Ludwig, Mangat, Mortier, Mortier, Murphy, Murphy, Peichl, Persson, Prevoo, Proost, Ruth, Ruth, Schellekens, Sebbag, Senshu, Snir, Steendam, Strieter, Struyf, Suzuki, Szekanecz, Tak, Tsuji, Venrooij, Vossenaar, Walz, Wuyts, Zlotnik   +50 more
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Conserved Citrullinating Exoenzymes inPorphyromonasSpecies

Journal of Dental Research, 2018
Porphyromonas gingivalis is one of the major oral pathogens implicated in the widespread inflammatory disorder periodontitis. Moreover, in recent years, P. gingivalis has been associated with the autoimmune disease rheumatoid arthritis. The peptidylarginine deiminase enzyme of P.
Gabarrini, G., Chlebowicz, M.A., Vega Quiroz, M.E., Veloo, A.C.M., Rossen, J.W.A., Harmsen, H.J.M., Laine, M.L., van Dijl, J.M., van Winkelhoff, A.J.   +8 more
openaire   +6 more sources

Peptidylarginine deiminase and deiminated proteins are detected throughout early halibut ontogeny - Complement components C3 and C4 are post-translationally deiminated in halibut (Hippoglossus hippoglossus L.) [PDF]

, 2019
Post-translational protein deimination is mediated by peptidylarginine deiminases (PADs), which are calcium dependent enzymes conserved throughout phylogeny with physiological and pathophysiological roles. Protein deimination occurs via the conversion of
Bowden, T., Bowden, T., Bragason, B.T., Bragason, B.T., Bricknell, I.R., Bricknell, I.R., Dodds, A.W., Dodds, A.W., Gudmundsdottir, S., Gudmundsdottir, S., Hristova, M., Hristova, M., Lange, S., Lange, S., Magnadóttir, B., Magnadóttir, B., Nicholas, A.P., Nicholas, A.P.   +17 more
core   +3 more sources