Results 51 to 60 of about 14,198 (253)

Applicability of Small-Molecule Inhibitors in the Study of Peptidyl Arginine Deiminase 2 (PAD2) and PAD4

Frontiers in Immunology, 2021
Citrullination, the conversion of peptidyl-arginine into peptidyl-citrulline, is involved in the breakage of self-tolerance in anti-CCP-positive rheumatoid arthritis.
María Teresa Martín Monreal, Alexandra Stripp Rebak, Laura Massarenti, Santanu Mondal, Ladislav Šenolt, Niels Ødum, Michael L. Nielsen, Paul R. Thompson, Claus H. Nielsen, Claus H. Nielsen, Dres Damgaard   +10 more
doaj   +1 more source

The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease. [PDF]

J Intern Med
Abstract The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection‐caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation, and inactivation of innate immune proteins necessary for direct antimicrobial effects and ...
Barron AE, Lin JS, Ryder MI, Bergman P.
europepmc   +2 more sources

Autophagy and rheumatoid arthritis: Current knowledges and future perspectives [PDF]

, 2018
Autophagy is a degradation mechanism by which cells recycle cytoplasmic components to generate energy. By influencing lymphocyte development, survival, and proliferation, autophagy regulates the immune responses against self and non-self antigens ...
Alessandri, Cristiano, Barbati, Cristiana, Ceccarelli, Fulvia, Colasanti, Tania, Conti, Fabrizio, Franco, Manuela Di, Novelli, Lucia, Perricone, Carlo, Spinelli, Francesca Romana, Valesini, Guido, Vomero, Marta   +10 more
core   +2 more sources

Deep Learning Enhances Precision of Citrullination Identification in Human and Plant Tissue Proteomes. [PDF]

Mol Cell Proteomics
Gabriel W, González RM, Laposchan S, Riedel E, Dündar G, Poppenberger B, Wilhelm M, Lee CY.   +7 more
europepmc   +2 more sources

Upregulation of citrullination pathway: From Autoimmune to Idiopathic Lung Fibrosis

Respiratory Research, 2017
Background Increased protein citrullination and peptidylarginine deiminases (PADIs), which catalyze the citrullination process, are central in Rheumatoid arthritis pathogenesis and probably involved in the initial steps towards autoimmunity ...
Katerina D. Samara, Athina Trachalaki, Eliza Tsitoura, Anastasios V. Koutsopoulos, Eleni D. Lagoudaki, Ismini Lasithiotaki, George Margaritopoulos, Panagiotis Pantelidis, Eleni Bibaki, Nikolaos M. Siafakas, Nikolaos Tzanakis, Athol U. Wells, Katerina M. Antoniou   +12 more
doaj   +1 more source

Detection and quantification of citrullinated chemokines. [PDF]

PLoS ONE, 2011
BackgroundPosttranslational deimination or citrullination by peptidylarginine deiminases (PAD) regulates the biological function of proteins and may be involved in the development of autoimmune diseases such as rheumatoid arthritis and multiple sclerosis.
Eva A V Moelants, Jo Van Damme, Paul Proost   +2 more
doaj   +1 more source

Implications of Porphyromonas gingivalis peptidyl arginine deiminase and gingipain R in human health and diseases

Frontiers in Cellular and Infection Microbiology, 2022
Porphyromonas gingivalis is a major pathogenic bacterium involved in the pathogenesis of periodontitis. Citrullination has been reported as the underlying mechanism of the pathogenesis, which relies on the interplay between two virulence factors of the ...
Yoke Chan Chow, Hok Chai Yam, Baskaran Gunasekaran, Weng Yeen Lai, Weng Yue Wo, Tarun Agarwal, Yien Yien Ong, Siew Lee Cheong, Sheri-Ann Tan   +8 more
doaj   +1 more source

Prevalence, sensitivity and specificity of antibodies against carbamylated proteins in a monocentric cohort of patients with rheumatoid arthritis and other autoimmune rheumatic diseases [PDF]

, 2016
Antibodies against carbamylated proteins (anti-CarP) have been recently identified in the sera of patients with rheumatoid arthritis (RA). The objective of the study was to evaluate the prevalence, sensitivity and specificity of anti-CarP compared to ...
Alessandri, Cristiano, Barbati, Cristiana, Ceccarelli, Fulvia, Colasanti, Tania, Conti, Fabrizio, DI FRANCO, Manuela, Mancini, Riccardo, Morello, Francesca, Pecani, Arbi, Pendolino, Monica, Priori, Roberta, Riccieri, Valeria, Sabatinelli, Danilo, Spinelli, FRANCESCA ROMANA, Truglia, Simona, Valesini, Guido, Vomero, Marta   +16 more
core   +1 more source

Citrullination of matrisomal proteins in health and diseases

Philosophical Transactions of the Royal Society of London. Biological Sciences, 2023
Proteins once translated are subjected to post-translational modifications (PTMs) that can critically modify their characteristics. Citrullination is a unique type of PTM that is catalysed by peptidylarginine deiminase (PAD) enzymes, which regulate a ...
M. A. Saifi, I-Cheng Ho
semanticscholar   +1 more source

Belimumab Decreases Autophagy and Citrullination in Peripheral Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus

Cells, 2022
Belimumab (BLM) is a B lymphocyte stimulator (BLyS) inhibitor approved for the treatment of systemic lupus erythematosus (SLE). Autophagy is a cell survival mechanism involved in the pathogenesis of SLE.
Tania Colasanti, Francesca Romana Spinelli, Cristiana Barbati, Fulvia Ceccarelli, Susanna Scarpa, Marta Vomero, Cristiano Alessandri, Guido Valesini, Fabrizio Conti   +8 more
doaj   +1 more source