Results 11 to 20 of about 55,491 (303)

Enhancement of fracture healing after citrulline supplementation in mice [PDF]

European Cells & Materials, 2020
Around 10 % of long bone fractures show inadequate bone healing resulting in non-union development. A deregulated arginine-citrulline-nitric oxide metabolism caused by a poor nutritional status of the patients is a risk factor for non-unions ...
DM Meesters, PFW Hannemann,, HMH van Eijk, VTJ Schriebl, PRG Brink, M Poeze, KAP Wijnands   +6 more
doaj   +1 more source

Assessing Non-Invasive Liver Function in Patients With Intestinal Failure Receiving Total Parenteral Nutrition-Results From the Prospective PNLiver Trial [PDF]

, 2020
Liver abnormalities in intestinal failure (IF) patients receiving parenteral nutrition (PN) can progress undetected by standard laboratory tests to intestinal failure associated liver disease (IFALD). The aim of this longitudinal study is to evaluate the
Bednarsch, Jan, Blüthner, Elisabeth, Gerlach-Runge, Undine, Karber, Mirjam, Maasberg, Sebastian, Pape, Ulrich-Frank, Pascher, Andreas, Pevny, Sophie, Pratschke, Johann, Stockmann, Martin, Tacke, Frank   +10 more
core   +1 more source

L-citrulline increases arginase II protein levels and arginase activity in hypoxic piglet pulmonary artery endothelial cells

Pulmonary Circulation, 2021
The L-arginine precursor, L-citrulline, re-couples endothelial nitric oxide synthase, increases nitric oxide production, and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs.
Matthew S. Douglass, Yongmei Zhang, Mark R. Kaplowitz, Candice D. Fike   +3 more
doaj   +1 more source

Evaluation of the Utility of Amino Acid Citrulline as a Surrogate Metabolomic Biomarker for the Diagnosis of Celiac Disease

Nutrition and Metabolic Insights, 2021
Introduction: Citrulline is regarded as a biomarker for celiac disease (CD). Its utility for assessment and evaluation of additive predictive value for latent, potential CD and first degree relatives (FDRs) needs exploration.
Avinash Lomash, Anupa Prasad, Raghvendra Singh, Somesh Kumar, Rishi Gupta, Dhwani Dholakia, Praveen Kumar, Vineeta V Batra, Amarender S Puri, Seema Kapoor   +9 more
doaj   +1 more source

Citrulline inhibits LPS‐induced pyroptosis of RAW264.7 macrophages through NF‐κB signaling pathway

Immunity, Inflammation and Disease, 2023
Background The aim of this study was to investigate the effect of citrulline on the pyroptosis of mouse macrophage RAW264.7 and the mechanism. We investigated the effect of citrulline on pyroptosis of RAW264.7 cell induced by lipopolysaccharide (LPS ...
Li Yin, Xiaomin Wei, Yanjun Zhang, Chengshu Lu, Huakun Wang   +4 more
doaj   +1 more source

Functional Relevance of Citrulline in the Vegetative Tissues of Watermelon During Abiotic Stresses

Frontiers in Plant Science, 2020
A non-protein amino acid, citrulline, is a compatible solute involved in the maintenance of cellular osmolarity during abiotic stresses. Despite its significance, a coherent model indicating the role of citrulline during stress conditions has not yet ...
Qiushuo Song, Qiushuo Song, Madhumita Joshi, James DiPiazza, Vijay Joshi, Vijay Joshi   +5 more
doaj   +1 more source

Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis [PDF]

, 2009
Antibodies to citrulline-modifi ed proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological role in disease development is still unclear.
Aho, Andersson, Auger, Baeten, Bella, Bettina Sehnert, Brunsberg, Burkhardt, Burkhardt, Bäcklund, Caspi, Chang, Chapuy-Regaud, Collaborative Computational Project, Number 4, DeLano, Dyson, Emsley, Emsley, Emsley, Estelle Bajtner, Foulquier, Girbal-Neuhauser, Giudicelli, Grab, Guy Serre, Harald Burkhardt, Hill, Hill, Hoffmann, Hüseyin Uysal, Kabsch, Kanazawa, Kidd, Krissinel, Kuhn, Kutty S. Nandakumar, Lefranc, Marjolein M.G.M. Thunnissen, Masson-Bessière, Masson-Bessière, Michaëlsson, Molberg, Murshudov, Nair, Nandakumar, Rantapää-Dahlqvist, Read, Reparon-Schuijt, Rikard Holmdahl, Robert Bockermann, Rosloniec, Schellekens, Schellekens, Schulte, Schwab, Stanfield, Stetefeld, Tarcsa, Uysal, van der Helm-van Mil, Vander Cruyssen, von Delwig, Vossenaar, Vossenaar, Vossenaar, Vossenaar, Winn, Yousfi Monod, Zong, Åke Engström   +69 more
core   +2 more sources

L-Citrulline Protects Skeletal Muscle Cells from Cachectic Stimuli through an iNOS-Dependent Mechanism. [PDF]

PLoS ONE, 2015
Dietary L-citrulline is thought to modulate muscle protein turnover by increasing L-arginine availability. To date, the direct effects of increased L-citrulline concentrations in muscle have been completely neglected. Therefore, we determined the role of
Daniel J Ham, Benjamin G Gleeson, Annabel Chee, Dale M Baum, Marissa K Caldow, Gordon S Lynch, René Koopman   +6 more
doaj   +1 more source

Sodium-coupled neutral amino acid transporter 1 (SNAT1) modulates L-citrulline transport and nitric oxide (NO) signaling in piglet pulmonary arterial endothelial cells. [PDF]

PLoS ONE, 2014
There is evidence that impairments in nitric oxide (NO) signaling contribute to chronic hypoxia-induced pulmonary hypertension. The L-arginine-NO precursor, L-citrulline, has been shown to ameliorate pulmonary hypertension.
Anna Dikalova, Angela Fagiana, Judy L Aschner, Michael Aschner, Marshall Summar, Candice D Fike   +5 more
doaj   +1 more source

Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies [PDF]

, 2016
OBJECTIVES: Autophagy may represent a functional processing event that creates a substrate for autoreactivity. In particular, autophagy may play a role in the pathogenesis of RA, since autophagy is a key cellular event involved in the generation of ...
Alessandra Nerviani, Antonella Capozzi, Cristiano Alessandri, Cristina Iannuccelli, Emanuela Lococo, Guido Valesini, Kato, Manuela Di Franco, Maurizio Sorice, Michele Bombardieri, Neumann, Pickl, Roberta Misasi, Tina Garofalo, Valeria Manganelli   +14 more
core   +1 more source