Results 21 to 30 of about 55,491 (303)
Rheumatoid arthritis and citrullination [PDF]
Current Opinion in Rheumatology, 2018 Purpose of reviewDysregulated citrullination is a key element that drives the production and maintenance of antibodies to citrullinated proteins, a hallmark in rheumatoid arthritis (RA). This article reviews recent literature on the origin of citrullinated antigens in RA.Recent findingsThe study of synovial fluid from patients with RA has provided ...
Erika, Darrah, Felipe, Andrade
openaire +2 more sources
Journal of Pharmacological Sciences, 2015 l-Citrulline is an effective precursor of l-arginine produced by the l-citrulline/l-arginine cycle, and it exerts beneficial effects on the cardiovascular system by supporting enhanced nitric oxide (NO) production.
Asami Mori +5 more
doaj +1 more source
Enhancement of anti-programmed cell death protein-1 immunotherapy in non-small cell lung cancer using arginine and citrulline supplementation [PDF]
J Thorac DisMiyamoto N +6 more
europepmc +3 more sources
Chemoreactomic analysis of citrulline malate molecules
Неврология, нейропсихиатрия, психосоматика, 2017 Citrulline malate that is essential for the biosynthesis of arginine promotes dehydration of ammonium endotoxins, by participating in the urea cycle. The indications for the use of citrulline malate are functional asthenia, asthenic syndrome, overfatigue,
I. Yu. Torshin +4 more
doaj +1 more source
Does canine inflammatory bowel disease influence gut microbial profile and host metabolism? [PDF]
, 2016 Background: Inflammatory bowel disease (IBD) refers to a diverse group of chronic gastrointestinal diseases, and gut microbial dysbiosis has been proposed as a modulating factor in its pathogenesis.
Bosch, Guido +13 more
core +2 more sources
Estrogen stimulates dimethylarginine dimethylaminohydrolase activity and the metabolism of asymmetric dimethylarginine. [PDF]
, 2003 Background— Experimental evidence suggests that estrogens stimulate the production of nitric oxide (NO) by vascular endothelial cells. This effect has been attributed to increased expression and enzymatic activity of both the constitutive and inducible ...
Cartwright, JE +3 more
core +1 more source
Citrullination and Autophagy [PDF]
, 2017 During evolution, the eukaryotic cells develop different processes in order to adapt themselves to environmental changes, as well as to die or to survive. These processes include apoptosis, NETosis, and autophagy: citrullination is implicated in all of these physiological mechanisms.
Guido Valesini +5 more
openaire +1 more source
Autophagy, citrullination and cancer [PDF]
Autophagy, 2016 A cell needs to maintain a balance between biosynthesis and degradation of cellular components to maintain homeostasis. There are 2 pathways, the proteasome, which degrades short-lived proteins, and the autophagy/lysosomal pathway, which degrades long-lived proteins and organelles. Both of these pathways are also involved in antigen presentation or the
Lindy G, Durrant +2 more
openaire +2 more sources
Increased plasma citrulline in mice marks diet-induced obesity and may predict the development of the metabolic syndrome. [PDF]
PLoS ONE, 2013 In humans, plasma amino acid concentrations of branched-chain amino acids (BCAA) and aromatic amino acids (AAA) increase in states of obesity, insulin resistance and diabetes.
Manuela Sailer +8 more
doaj +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source