Results 31 to 40 of about 55,491 (303)
Antioxidants, 2022 Intermittent hypoxia (IH) is a landmark of obstructive sleep apnea (OSA) at the core of the cardiovascular consequences of OSA. IH triggers oxidative stress, a major underlying mechanism for elevated blood pressure (BP) and increased infarct size.
Bilgehan Ozcan +10 more
doaj +1 more source
Citrulline a more suitable substrate than arginine to restore NO production and the microcirculation during endotoxemia. [PDF]
PLoS ONE, 2012 BACKGROUND: Impaired microcirculation during endotoxemia correlates with a disturbed arginine-nitric oxide (NO) metabolism and is associated with deteriorating organ function.
Karolina A P Wijnands +6 more
doaj +1 more source
Revista Brasileira de Zootecnia, 2023 In this study, we aimed to determine the effect of Moringa oleifera essential oil (MOEO) supplementation to rations of Japanese quail ( Coturnix coturnix japonica ) grown under heat stress (HS) on some adipokine (visfatin, adiponectin, and chemerin ...
Bülent Bayraktar +9 more
doaj +1 more source
Citrulline as a marker of intestinal function and absorption in clinical settings: A systematic review and meta-analysis [PDF]
, 2017 Background: Citrulline has been described as a marker of intestinal function or absorption but evidence varies according to clinical settings. Objective: The objective of this article is to examine the evidence of plasma citrulline as a marker of ...
Blasco Alonso J +11 more
core +3 more sources
Biochemical, Clinical, and Functional Characterization of a Rare c.-106C>A Promoter Region Variant in Late-Onset Ornithine Transcarbamylase Deficiency: A Multifamily Case Series. [PDF]
JIMD RepABSTRACT Ornithine transcarbamylase (OTC) deficiency can present during the neonatal period, infancy, or adulthood. Late‐onset phenotypes are influenced by residual enzyme activity and OTC gene expression. The objective of this study was to assess the pathogenicity of a rare promoter region variant, c.‐106C>A.
Tholl SQ +9 more
europepmc +2 more sources
Quantification of IFNγ- and IL17-producing cells after stimulation with citrullinated proteins in healthy subjects and RA patients [PDF]
, 2013 Antibodies against citrullinated proteins are highly specific for rheumatoid arthritis (RA) and are currently used as a diagnostic marker. In this study, we wanted to quantify the numbers of T cells that react to a wide range of citrullinated proteins in
De Ceuleneer, Marlies +5 more
core +1 more source
Citrullination in Cancer [PDF]
Cancer Research, 2019 Abstract Posttranslational modifications of proteins have been implicated in pathogenesis of numerous diseases. Arginine deimination (also known as citrullination) has a principal role in progression of rheumatoid arthritis through generation of autoantibodies and exacerbation of the inflammatory response.
openaire +2 more sources
PLoS ONE, 2019 Clinical and model studies indicate that low nitric oxide (NO) bioavailability due in part to profound hypoargininemia contributes to cerebral malaria (CM) pathogenesis.
Irene Gramaglia +7 more
doaj +1 more source
Immune recognition of citrullinated epitopes [PDF]
Immunology, 2016 SummaryConversion of arginine into citrulline is a post‐translational modification that is observed in normal physiological processes. However, abnormal citrullination can provoke autoimmunity by generating altered self‐epitopes that are specifically targeted by autoantibodies and T cells.
Hai, Nguyen, Eddie A, James
openaire +2 more sources
Translating Metabolic Reprogramming into New Targets for Kidney Cancer. [PDF]
, 2017 In the age of bioinformatics and with the advent of high-powered computation over the past decade or so the landscape of biomedical research has become radically altered.
Abu Aboud, Omran, Weiss, Robert H
core +1 more source