Results 71 to 80 of about 51,040 (246)

Cytosolic Phosphoenoylpyruvate Carboxykinase Deficiency: Clinical, Biochemical, and Genetic Features of Five Non‐Finnish Patients

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Cytosolic phosphoenoylpyruvate carboxykinase (PEPCK‐C) is an essential, rate‐limiting enzyme in the gluconeogenesis pathway. PEPCK‐C deficiency presents with hypoglycaemia, hyperlactataemia and hepatopathy, and was first reported in association with bi‐allelic PCK1 variants in 2014.
Isaac Bernhardt, Polona Le Quesne Stabej, Claire Hart, Mark De Hora, Sarah Hulley, Mark Anderson, Harry G. Leitch, Hugh Lemonde, Bryony Ryder, James Davison   +9 more
wiley   +1 more source

Biosynthesis of Citrulline in Plants [PDF]

Nature, 1961
IN 1930 citrulline was discovered in water-melons1. Later it was shown to be an important participant in the Krebs and Henseleit ornithine cycle in animals and micro-organisms. In recent years several laboratories have worked on the ornithine cycle in plants.
openaire   +2 more sources

Citrulline: from metabolism to therapeutic use.: citrulline: metabolism and therapeutic [PDF]

, 2013
International audienceCitrulline possesses a highly specific metabolism that bypasses splanchnic extraction because it is not used by the intestine or taken up by the liver.
Aussel, Christian, Bahri, Senda, Chaumeil, Jean-Claude, Crenn, Pascal, Curis, Emmanuel, Cynober, Luc, Moinard, Christophe, Sfar, Souad, Zerrouk, Naima   +8 more
core   +4 more sources

Conformational Plasticity of HLA-B27 Molecules Correlates Inversely With Efficiency of Negative T Cell Selection [PDF]

, 2020
The development of autoimmune disorders is incompletely understood. Inefficient thymic T cell selection against self-peptides presented by major histocompatibility antigens (HLA in humans) may contribute to the emergence of auto-reactive effector cells ...
Loll, Bernhard, Rückert, Christine, Uchanska-Ziegler, Barbara, Ziegler, Andreas   +3 more
core   +1 more source

Reduction of Ribonucleotide Reductase Subunit RRM2 Potentially Impairs Gut Function of Woody Breast Broilers

Animal Research and One Health, EarlyView.
Woody breast compromises meat quality leading to reduced consumer appeal. Although its causes are unclear, improvements observed with certain dietary supplements suggest that gut health may influence woody breast development. Ribonucleotide reductase subunit RRM2 is vital for mitochondrial function and gastrointestinal integrity, and alteration in its ...
Majid Shakeri, Elizabeth Ziabtchenko, Janghan Choi, Caitlin E. Harris, Richard J. Buhr, Trevor R. Mitchell, Byungwhi Kong, Hong Zhuang, Brian Bowker   +8 more
wiley   +1 more source

Synthetic Cathepsin B Sensitive Adjuvant‐Peptide Conjugates to Target Intracellular Toll‐Like Receptors 7 and 8

ChemistryEurope, EarlyView.
Cathepsin B‐sensitive peptide–adjuvant conjugates are designed, synthesized, and evaluated to deliver an antigenic peptid and an adjuvant targeting Toll‐like receptors 7 and 8 (TLR7/8) to antigen presenting cells. The adjuvant is released by cathepsin B resulting in antigen presentation and TLR mediated T cell activation.
Marjolein M. E. Isendoorn, Giulia Castello, Nico J. Meeuwenoord, Martijn Verdoes, Jeroen D. C. Codée, Ferry Ossendorp, Dmitri V. Filippov   +6 more
wiley   +1 more source

Determination of Citrulline in Plasma

Clinical Chemistry, 1960
Abstract The Archibald method for the determination of plasma citrulline has been modified to eliminate the dialysis step in order to separate citrulline from plasma proteins. Instead these are precipitated with picric acid and the picrate ion removed by passage through an anion exchange column.
M P, MOCKLER, L R, MENEBROKER, F L, HUMOLLER, A J, BARAK   +3 more
openaire   +2 more sources

Citrullinated fibrinogen detected as a soluble citrullinated autoantigen in rheumatoid arthritis synovial fluids [PDF]

Annals of the Rheumatic Diseases, 2006
Anti-citrullinated protein antibodies (ACPA) are specifically and frequently detected in sera of patients with rheumatoid arthritis (RA). Citrullinated fibrin or fibrinogen is a candidate autoantigen of such antibodies.To investigate the presence of citrullinated fibrinogen (cFBG) in the plasma or synovial fluid of patients with RA and control patients,
Y, Takizawa, A, Suzuki, T, Sawada, M, Ohsaka, T, Inoue, R, Yamada, K, Yamamoto   +6 more
openaire   +2 more sources

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Citrulline Evaluation in Bowel Transplantation

Transplantation Proceedings, 2010
The purpose of this study was to evaluate the correlation of plasma citrulline and rejection episodes in intestinal transplantation.From January 2007 until present, we performed citrulline assays on our small bowel patients. We investigated the correlation of these assays with the rejection status of the patients.
Department of Surgery, University of Miami School of Medicine, Miami, Florida, USA ( host institution ), Ruiz, P. ( author ), Tryphonopoulos, P. ( author ), Island, E. ( author ), Selvaggi, G. ( author ), Nishida, S. ( author ), Moon, J. ( author ), Berlanga, A. ( author ), Defranc, T. ( author ), Levi, D. ( author ), Tekin, A. ( author ), Tzakis, A.G. ( author )   +11 more
openaire   +3 more sources