Results 51 to 60 of about 409,684 (298)
ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy
Advanced Science, EarlyView.A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou +9 more
wiley +1 more source
TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia
CNS Neuroscience &Therapeutics, EarlyView., 2023 Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi +19 more
wiley +1 more source
Comparison of conjugated linoleic acid and other fatty acid content of milk fat of mafriwal and jersey cows. [PDF]
, 2010 Special attention has been given to the milk Fatty Acids (FA) that have a beneficial effect for human health such as mono and poly unsaturated fatty acids in particularly the Conjugated Linoleic Acids (CLA).
Abd. Kadir, Arifah +4 more
core +1 more source
The Anatomical Record, EarlyView.Abstract The Upper Cretaceous São José do Rio Preto Formation (Bauru Group, southeastern Brazil) has yielded a fragmentary but taxonomically diverse record of titanosaur sauropods, although elements from cervical series remain scarce. Here, we describe a nearly complete sauropod axis from the Vila Ventura Paleontological Area, representing an uncommon ...
Bruno A. Navarro +7 more
wiley +1 more source
Animal Research and One Health, EarlyView.Unregulated inflammation increases non‐esterified fatty acids (NEFAs), and triggers multi‐pathway hepatocyte damage including oxidative stress, mitochondrial dysfunction, and metabolic disorders in dairy cows. ABSTRACT Circulating concentrations of nonesterified fatty acids (NEFAs) are elevated due to lipid mobilization from adipose tissue in ...
Siqing Mao +12 more
wiley +1 more source
Czech Journal of Animal Science, 2013 Two concentrates, one protein-rich and one based on cereals, were combined with two silages with a crude protein content of 17 and 13% of dry matter (DM), respectively to give four different diets for dairy cows.
M. Johansson +6 more
doaj +1 more source
Endoscopic laser-ablation for the treatment of orthotopic and ectopic ureteroceles in dogs: 13 cases (2008-2017). [PDF]
, 2019 BACKGROUND: Ureteroceles are a rare condition in dogs in which conventional treatments can result in substantial morbidity. Cystoscopic and fluoroscopic-guided laser ablation (CLA) of ureteroceles can successfully relieve obstruction.
Ather MH +9 more
core +2 more sources
Arthritis &Rheumatology, Accepted Article.Objective To develop, externally validate, and simplify a machine‐learning (ML) model to predict remission between six and 24 months in rheumatoid arthritis (RA) patients initiating TNF inhibitors, JAK inhibitors, IL‐6 inhibitors, abatacept, or rituximab, using data from 11 international registries in the JAK‐pot collaboration.
Zubeyir Salis +22 more
wiley +1 more source
Effect of microbial oil, evening primrose oil and borage oil on rumen fermentation in vitro
Veterinární Medicína, 2005 The objective of this study was to examine the effects of microbial oil, evening primrose oil and borage oil on rumen fermentation of a diet consisting of 80% of hay and 20% of barley in an artificial rumen (Rusitec).
D. Jalc +4 more
doaj +1 more source
Influence of organic diet on the amount of conjugated linoleic acids in breast milk of lactating women in the Netherlands [PDF]
, 2007 The aim of the present study was to find out whether the incorporation of organic dairy and meat products in the maternal diet affects the contents of the conjugated linoleic acid isomers (CLA) and trans-vaccenic acid (TVA) in human breast milk.
Barthel, Christiane +10 more
core +2 more sources