Results 11 to 20 of about 2,368,811 (205)

Clarithromycin Resistance in Helicobacter Pylori [PDF]

Central Asian Journal of Medical Sciences, 2016
Objectives: Eradication rates of Helicobacter pylori with standard triple therapy are disappointing in studies from several countries. The main reason for failure was found to be bacterial resistance to one of the most commonly used antibiotics ...
Mandkhai Bolor-Erdene, Bira Namdag, Sarantuya Jav   +2 more
doaj   +3 more sources

Pathophysiology of Antibiotic Resistance: Clarithromycin [PDF]

Canadian Journal of Gastroenterology, 2000
Resistance ofHelicobacter pylorito antibiotics ranges from 3% to 10% and may exceed these levels in some countries. The pathophysiology of clarithromycin resistance is reviewed, including the mode of action by which the antibiotic inhibits protein synthesis and the mechanism of resistance, which involves a mutation at position 2142 or 2143 in the V ...
Diane E Taylor
core   +6 more sources

Helicobacter pylori Primary and Secondary Genotypic Resistance to Clarithromycin and Levofloxacin Detection in Stools: A 4-Year Scenario in Southern Italy [PDF]

Antibiotics, 2020
Antibiotic resistance has become an emerging problem for treating Helicobacter pylori (H. pylori) infection. Clarithromycin and levofloxacin are two key antibiotics used for its eradication. Therefore, we reviewed our experience with genotypic resistance
Giuseppe Losurdo, Floriana Giorgio, Maria Pricci, Bruna Girardi, Francesco Russo, Giuseppe Riezzo, Manuela Martulli, Mariano Piazzolla, Francesco Cocomazzi, Francesco Abbruzzi, Elisabetta Parente, Rosa Paolillo, Alessia Mileti, Andrea Iannone, Mariabeatrice Principi, Enzo Ierardi, Alfredo Di Leo   +16 more
doaj   +3 more sources

Genotypic and Phenotypic Resistance to Clarithromycin in Helicobacter pylori Strains [PDF]

Journal of Clinical Medicine, 2020
Background: The increasing prevalence of antimicrobial resistance, together with the lack of novel treatment options, negatively affects successful eradication of Helicobacter pylori. The aim of this study was to investigate genetic mutations in the 23S rRNA genes, which is associated with clarithromycin resistance, and to determine the clinical impact
Eun Jeong Gong, Ji Yong Ahn, Jung Mogg Kim, Sun Mi Lee, Hee Kyong Na, Jeong Hoon Lee, Kee Wook Jung, Kee Don Choi, Do Hoon Kim, Ho June Song, Gin Hyug Lee, So Won Kim, Hwoon-Yong Jung   +12 more
openaire   +3 more sources

Clarithromycin resistance and 23S rRNA gene point mutations of Helicobacter pylori infection in children [PDF]

The Turkish Journal of Pediatrics, 2016
This study aims to evaluate Helicobacter pylori with clarithromycin resistant genotypes in Manisa region, Turkey. Two hundred patients, who received diagnosis of Helicobacter pylori infection histopathologically, were included.
Yeliz Çağan-Appak, Hörü Gazi, Semin Ayhan, Beyhan Cengiz-Özyurt, Semra Kurutepe, Erhun Kasırga   +5 more
doaj   +3 more sources

High Prevalence of hefA Efflux Pump Overexpression in Isolates of Helicobacter pylori Resistant to Clarithromycin

Antibiotics
Background/Objectives: Helicobacter pylori is a cause of chronic gastric infections and gastrointestinal carcinogenesis, with a prevalence of 20–90% around the world.
Marcela Villegas, Catalina Ortega, Krishna Gómez, Alvaro Cerda, Rolando Sepúlveda, Christian Lara, Luis Bustamante, Daniela Garcia, Luis Coppelli, Edmundo Hofmann, Armando Sierralta, Mónica Pavez   +11 more
doaj   +2 more sources

Primary clarithromycin resistance in Helicobacter pylori: the Multicentric Italian Clarithromycin Resistance Observational (MICRO) study.

Journal of gastrointestinal and liver diseases : JGLD, 2011
Primary clarithromycin resistance markedly reduces Helicobacter pylori eradication rate following standard therapies. Prevalence of primary clarithromycin resistance in H. pylori is increasing, and three point mutations are mainly involved. AIM. To assess both the prevalence of primary clarithromycin resistance in Italy, and the distribution of the ...
De Francesco V, Giorgio F, Ierardi E, Zotti M, Neri M, Milano A, Varasano V, Luzza F, Suraci E, Marmo R, Marone A, Manta R, Mirante VG, de Matthaeis M, Pedroni A, Manes G, Pallotta S, USAI, PAOLO, Liggi M, Gatto G, Peri V, Sacco R, Bresci G, Monica F, Hassan C, Zullo A.   +25 more
openaire   +4 more sources

Lipopolysaccharide glycotyping of clarithromycin-resistant and clarithromycin-susceptible Canadian isolates ofHelicobacter pylori

Canadian Journal of Microbiology, 2014
Lipopolysaccharide (LPS) of Helicobacter pylori exhibits several unique structures, such as Lewis (Le) antigens, α-1,6-glucan, and dd-heptan. To investigate the relationship between LPS structure and resistance to clarithromycin, 41 Canadian isolates of H. pylori were characterized by whole-cell ELISA (enzyme-linked immunosorbent assay), sugar analysis,
Altman, E., Harrison, B.A., Chandan, V., Slinger, R.   +3 more
openaire   +3 more sources

High Helicobacter pylori Resistance Rate to Clarithromycin in Turkey

Journal of Clinical Gastroenterology, 2007
To assess the resistance of Helicobacter pylori to clarithromycin in Turkey.Recent studies have emphasized the remarkable reduction in H. pylori eradication rates. Resistance to clarithromycin is the most important factor affecting the success of H. pylori eradication therapies.The study involved 110 consecutive adult dyspeptic patients infected with H.
Onder, Goktug, Aydin, Ahmet, Akarca, Ulus, Tekin, Fatih, Ozutemiz, Omer, Ilter, Tankut   +5 more
openaire   +4 more sources

Detection of A2142C, A2142G, and A2143G Mutations in 23s rRNA Gene Conferring Resistance to Clarithromycin among Helicobacter pylori Isolates in Kerman, Iran [PDF]

Iranian Journal of Medical Sciences, 2011
Background: Clarithromycin resistance in Helicbacter pylori has been found to be associated with point mutations in 23s rRNA gene leads to reduced affinity of the antibiotic to its ribosomal target or changing the site of methylation.
Hamid Abdollahi, Mohammad Savari, Mohammad Javad Zahed, Sodaif Darvish Moghadam, Mehdi Hayatbakhsh Abasi   +4 more
doaj   +1 more source