C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation [PDF]
Nature Communications, 2016 C1q is known to initiate the activation of the complement classical pathway. Here, the authors show the C1q is expressed in the tumour microenvironment and can promote cancer cell migration and adhesion in a complement activation-independent manner.
Roberta Bulla +9 more
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The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection. [PDF]
PLoS Pathogens, 2012 The complement system plays a key role in host defense against pneumococcal infection. Three different pathways, the classical, alternative and lectin pathways, mediate complement activation.
Youssif M Ali +15 more
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Classical and alternative complement pathway activation by pneumococci [PDF]
Infection and Immunity, 1977 Sixty-two strains of Streptococcus pneumoniae were studied for their abilities to consume selected components of classical and alternative complement pathways in human sera. The classical pathway was blocked by chelating calcium with ethyleneglycol-bios (beta-aminoethyl ether)-N,N-tetraacetic acid and by removing C4. The alternative pathway was blocked
C G, Stephens, R C, Williams, W P, Reed
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Modern view on the complement system role in membranous nephropathy
Терапевтический архив, 2022 Membranous nephropathy (MN), an immune-mediated glomerular disease, is the most common cause of adult nephrotic syndrome. In MN, proteinuria is developed by podocyte damage due to the complement system activation in response to the subepithelial ...
Elena S. Kamyshova +2 more
doaj +1 more source
Evidence for classic complement activity in neuromyelitis optica [PDF]
Clinical Neuropathology, 2014 Abstract not available.
Jones, Melina V. +2 more
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Antibody-independent complement activation by myelin via the classical complement pathway [PDF]
Molecular Immunology, 1982 Murine or rabbit whole brain homogenates were shown to activate human complement via the classical pathway by an antibody-independent reaction. This activity required Ca++ ions. Anticomplementary activity in fractionated murine brain was found to reside in the myelin fraction and in purified myelin.
J.C. Cyong +3 more
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Multiple-Organ Complement Deposition on Vascular Endothelium in COVID-19 Patients
Biomedicines, 2021 Increased levels of circulating complement activation products have been reported in COVID-19 patients, but only limited information is available on complement involvement at the tissue level.
Paolo Macor +9 more
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Legionella pneumophila lipopolysaccharide activates the classical complement pathway [PDF]
Infection and Immunity, 1992 Legionella pneumophila is a gram-negative bacterium capable of entering and growing in alveolar macrophages and monocytes. Complement and complement receptors are important in the uptake of L. pneumophila by human mononuclear phagocytes. The surface molecules of L. pneumophila that activate the complement system are unknown.
C S, Mintz +3 more
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Profiling Complement System Components in Primary CNS Vasculitis
Cells, 2021 Complement activation has been implicated in the pathogenesis of many vasculitic syndromes such as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides.
Milani Deb-Chatterji +6 more
doaj +1 more source
Continual Low-Level Activation of the Classical Complement Pathway [PDF]
The Journal of Experimental Medicine, 2001 There is evidence that the classical complement pathway may be activated via a “C1-tickover” mechanism, analogous to the C3-tickover of the alternative pathway. We have quantitated and characterized this pathway of complement activation. Analysis of freshly collected mouse and human plasma revealed that spontaneous C3 activation rapidly occurred with ...
Manderson, A +4 more
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