Results 21 to 30 of about 76,398 (257)

Natural antibodies and CRP drive anaphylatoxin production by urate crystals

Scientific Reports, 2022
In gout, crystallization of uric acid in the form of monosodium urate (MSU) leads to a painful inflammatory response. MSU crystals induce inflammation by activating the complement system and various immune cell types, and by inducing necrotic cell death.
Anne Kathrin Wessig, Leonie Hoffmeister, Annika Klingberg, Anika Alberts, Andreas Pich, Korbinian Brand, Torsten Witte, Konstantin Neumann   +7 more
doaj   +1 more source

Hypoxic Processes Induce Complement Activation via Classical Pathway in Porcine Neuroretinas

Cells, 2021
Considering the fact that many retinal diseases are yet to be cured, the pathomechanisms of these multifactorial diseases need to be investigated in more detail.
Ana M. Mueller-Buehl, Torsten Buehner, Christiane Pfarrer, Leonie Deppe, Laura Peters, Burkhard H. Dick, Stephanie C. Joachim   +6 more
doaj   +1 more source

MINI-REVIEW: SYSTEMIC LUPUS ERYTHEMATOSUS AND DEFICIENCIES OF EARLY COMPONENTS OF THE COMPLEMENT CLASSICAL PATHWAY

Frontiers in Immunology, 2016
The complement system plays an important role in the innate and acquired immune response against pathogens. It consists of more than 30 proteins found in soluble form or attached to cell membranes. Most complement proteins circulate in inactive forms and
Lourdes eIsaac, Ana Catarina Lunz Macedo
doaj   +1 more source

Activation of the alternative and classical complement pathways by Entamoeba histolytica [PDF]

Infection and Immunity, 1985
Entamoeba histolytica HM1 supported the activation of human alternative and classical complement pathways in the absence of ameba-reactive antibodies. Nonimmune serum depleted of C1q and factor D (NHS s C1q + D) and reconstituted with C1q was able to specifically deposit C3b onto trophozoites and produce lysis.
J, Calderon, R D, Schreiber
openaire   +2 more sources

Classical complement pathway activation in membranoproliferative glomerulonephritis

Kidney International, 1976
Levels of components of the classical and alternative complement pathways and the activity of the C3 nephritic factor (C3NeF) were measured in serum specimens from patients with type I (subendothelial deposits) and type II (intramembranous dense deposits) membranoproliferative glomerulonephritis (MPGN) and the results compared with the levels in normal
Ooi, Yuet M., Vallota, Enrique H., West, Clark D.   +2 more
openaire   +2 more sources

Legionella pneumophila lipopolysaccharide activates the classical complement pathway [PDF]

Infection and Immunity, 1992
Legionella pneumophila is a gram-negative bacterium capable of entering and growing in alveolar macrophages and monocytes. Complement and complement receptors are important in the uptake of L. pneumophila by human mononuclear phagocytes. The surface molecules of L. pneumophila that activate the complement system are unknown.
C S, Mintz, D R, Schultz, P I, Arnold, W, Johnson   +3 more
openaire   +2 more sources

Peptide Inhibitor of Complement C1 (PIC1) Rapidly Inhibits Complement Activation after Intravascular Injection in Rats.

PLoS ONE, 2015
The complement system has been increasingly recognized to play a pivotal role in a variety of inflammatory and autoimmune diseases. Consequently, therapeutic modulators of the classical, lectin and alternative pathways of the complement system are ...
Julia A Sharp, Pamela S Hair, Haree K Pallera, Parvathi S Kumar, Clifford T Mauriello, Julius O Nyalwidhe, Cody A Phelps, Dalnam Park, Nicole M Thielens, Stephen M Pascal, Waldon Chen, Diane M Duffy, Frank A Lattanzio, Kenji M Cunnion, Neel K Krishna   +14 more
doaj   +1 more source

Complement Proteins as Soluble Pattern Recognition Receptors for Pathogenic Viruses

Viruses, 2021
The complement system represents a crucial part of innate immunity. It contains a diverse range of soluble activators, membrane-bound receptors, and regulators.
Valarmathy Murugaiah, Praveen M. Varghese, Nazar Beirag, Syreeta De Cordova, Robert B. Sim, Uday Kishore   +5 more
doaj   +1 more source

Characterization of Complement Activity in Turkeys: Evidence for Classical and Alternative Complement Pathways

Poultry Science, 1989
Complement activity in turkey serum was examined by using inhibitors or activators of mammalian complement. Hemolytic test systems using sheep red blood cells sensitized with specific antibody (SSRBC) and horse red blood cells (HRBC) were developed to measure residual complement activity of turkey sera treated with the various inhibitors or activators.
Ellis, M. G., Lamont, Susan, Arp, L. H.
openaire   +3 more sources

Classical Complement Pathway Activation in the Kidneys of Women With Preeclampsia [PDF]

Hypertension, 2015
A growing body of evidence suggests that complement dysregulation plays a role in the pathogenesis of preeclampsia. The kidney is one of the major organs affected in preeclampsia. Because the kidney is highly susceptible to complement activation, we hypothesized that preeclampsia is associated with renal complement activation. We performed a nationwide
Penning, M., Chua, J.S., Kooten, C. van, Zandbergen, M., Buurma, A., Schutte, J., Bruijn, J.A., Khankin, E.V., Bloemenkamp, K., Karumanchi, S.A., Baelde, H.   +10 more
openaire   +3 more sources