Results 11 to 20 of about 76,398 (257)
Alpha-synuclein activates the classical complement pathway and mediates complement-dependent cell toxicity [PDF]
Journal of Neuroinflammation, 2021 Background Synucleinopathies are characterized by neurodegeneration and deposition of the presynaptic protein α-synuclein in pathological protein inclusions.
Emil Gregersen +7 more
doaj +4 more sources
Classical and alternative complement pathway activation by pneumococci [PDF]
Infection and Immunity, 1977 Sixty-two strains of Streptococcus pneumoniae were studied for their abilities to consume selected components of classical and alternative complement pathways in human sera. The classical pathway was blocked by chelating calcium with ethyleneglycol-bios (beta-aminoethyl ether)-N,N-tetraacetic acid and by removing C4. The alternative pathway was blocked
C G, Stephens, R C, Williams, W P, Reed
openaire +2 more sources
Evidence for classic complement activity in neuromyelitis optica [PDF]
Clinical Neuropathology, 2014 Abstract not available.
Jones, Melina V. +2 more
openaire +2 more sources
Involvement of Antilipoarabinomannan Antibodies in Classical Complement Activation in Tuberculosis [PDF]
Clinical Diagnostic Laboratory Immunology, 1998 ABSTRACTWe examined alternative and classical complement activation induced by whole bacilli ofMycobacterium bovisBCG andMycobacterium tuberculosisproducts. After exposure to BCG, there were higher levels of the terminal complement complex in sera from Indian tuberculosis patients than in sera from healthy controls.
G, Hetland +5 more
openaire +2 more sources
SARS-CoV-2 Antibodies Mediate Complement and Cellular Driven Inflammation
Frontiers in Immunology, 2021 The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to constitute a serious public health threat worldwide.
Ida Jarlhelt +11 more
doaj +1 more source
Early complementopathy predicts the outcomes of patients with trauma
Trauma Surgery & Acute Care Open, 2019 Background Complementopathy (rapid complement activation and consumption after trauma) has been reported in trauma patients, but the underlying mechanism of these phenomena and their clinical significance remain unclear. This study aimed to determine the
Bin Liu +6 more
doaj +1 more source
Blood platelets activate the classical pathway of human complement [PDF]
Journal of Thrombosis and Haemostasis, 2006 Activation of the complement system plays a key role in inflammation associated with vascular injury. Recently, platelet P-selectin was shown to activate C3 via the alternative pathway of human complement. As platelets also posses binding sites for C1q, the recognition unit of the classical complement pathway, the present study examined classical ...
E I B, Peerschke +3 more
openaire +2 more sources
Renal Failure, 2022 Background Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN) is the fulminant glomerular diseases with poor renal prognosis. Activation of the complement system has recently been reported in the pathogenesis of AAGN, but it
Tadasu Kojima +6 more
doaj +1 more source
Frontiers in Immunology, 2019 Members of the PfEMP1 protein family are expressed on the surface of P. falciparum-infected erythrocytes (IEs), where they contribute to the pathogenesis of malaria and are important targets of acquired immunity.
Mads Delbo Larsen +8 more
doaj +1 more source
Trichinella spiralis Calreticulin Binds Human Complement C1q As an Immune Evasion Strategy
Frontiers in Immunology, 2017 As a multicellular parasitic nematode, Trichinella spiralis regulates host immune responses by producing a variety of immunomodulatory molecules to escape from host immune attack, but the mechanisms underlying the immune evasion are not well understood ...
Limei Zhao +13 more
doaj +1 more source