Results 51 to 60 of about 76,398 (257)

Effect of Moderate Aerobic Exercise on Complement Activation Pathways in Polycystic Ovary Syndrome Women

Frontiers in Endocrinology, 2022
BackgroundThe complement system is pivotal in host defense mechanisms, protecting against pathogenic infection by regulating inflammation and cell immunity.
Manjunath Ramanjaneya, Ibrahem Abdalhakam, Ilham Bettahi, Milin Bensila, Jayakumar Jerobin, Myint Myint Aye, Meis Alkasem, Thozhukat Sathyapalan, Stephen Lawrence Atkin, Abdul-Badi Abou-Samra   +9 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Oversulfated chondroitin sulfate inhibits the complement classical pathway by potentiating C1 inhibitor. [PDF]

PLoS ONE, 2012
Oversulfated chondroitin sulfate (OSCS) has become the subject of multidisciplinary investigation as a non-traditional contaminant in the heparin therapeutic preparations that were linked to severe adverse events.
Zhao-Hua Zhou, Mohsen Rajabi, Trina Chen, Elena Karnaukhova, Steven Kozlowski   +4 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Severe Congenital Thrombocytopenia Characterized by Decreased Platelet Sialylation and Moderate Complement Activation Caused by Novel Compound Heterozygous Variants in GNE

Frontiers in Immunology, 2021
BackgroundHereditary thrombocytopenias constitute a genetically heterogeneous cause of increased bleeding. We report a case of a 17-year-old boy suffering from severe macrothrombocytopenia throughout his life.
Karolina I. Smolag, Marcus Fager Ferrari, Eva Zetterberg, Eva Leinoe, Torben Ek, Anna M. Blom, Maria Rossing, Myriam Martin   +7 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Interaction of lactoferrin, lysozyme and the complement system in in vitro modeling of innate immune responses

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Complement is a key humoral participant of immunity involved in defensive and pathological processes. Human lysozyme (hLZ), hen egg white lysozyme (HEWL) and lactoferrin (LF) are classical constituents of innate immunity.
Ilia A. Krenev, Ekaterina S. Umnyakova, Alexey V. Sokolov, Nikolay P. Gorbunov, Valeria A. Kostevich, Galina M. Aleshina, Mikhail N. Berlov   +6 more
doaj   +1 more source

Hijacking the human complement inhibitor C4b-binding protein by the sporozoite stage of the Plasmodium falciparum parasite

Frontiers in Immunology, 2022
The complement system is considered the first line of defense against pathogens. Hijacking complement regulators from blood is a common evasion tactic of pathogens to inhibit complement activation on their surfaces.
Ayman Khattab, Ayman Khattab, Mikel Rezola, Marta Barroso, Mikael Kyrklund, Mikael Kyrklund, Tero Pihlajamaa, Tobias L. Freitag, Geert-Jan van Gemert, Teun Bousema, Perttu Permi, Perttu Permi, Ossi Turunen, Ossi Turunen, Robert Sauerwein, Adrian J. F. Luty, Seppo Meri, Seppo Meri, Seppo Meri   +18 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

An Excretory Protein of Echinococcus multilocularis Inhibits Complement Classical Pathway Activation

Infection and Drug Resistance, 2022
Yiwen Qiu, Shu Shen, Yi Yang, Wentao Wang Department of Liver Surgery and Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu, People’s Republic of ChinaCorrespondence: Wentao Wang, Department of Liver Surgery and Liver ...
Qiu Y, Shen S, Yang Y, Wang W
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