Circulating immune-complexes and complement activation through the classical pathway in myeloperoxidase-ANCA-associated glomerulonephritis [PDF]
Renal Failure, 2022 Background Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN) is the fulminant glomerular diseases with poor renal prognosis. Activation of the complement system has recently been reported in the pathogenesis of AAGN, but it
Tadasu Kojima +6 more
doaj +2 more sources
Absence of complement component 3 does not prevent classical pathway-mediated hemolysis. [PDF]
Blood Adv, 2019 Complement component 3 (C3) is emerging as a potential therapeutic target. We studied complement-mediated hemolysis using normal and C3-depleted human sera, wild-type (WT) and C3-deficient rat sera, and WT and C3 knockout rat models.
Lingjun Zhang +6 more
semanticscholar +2 more sources
Measuring Total Classical Pathway and Activities of Individual Components of the Mouse Complement Pathway [PDF]
Bio-Protocol, 2021 The complement system is a central component of innate immunity, responsible for recognition and killing of bacteria by tagging invaders through opsonisation, thereby promoting phagocytosis, and by direct lysis.
Wioleta Zelek
doaj +2 more sources
Comparing classical pathways and modern networks: towards the development of an edge ontology [PDF]
arXiv, 2007 Pathways are integral to systems biology. Their classical representation has proven useful but is inconsistent in the meaning assigned to each arrow (or edge) and inadvertently implies the isolation of one pathway from another. Conversely, modern high-throughput experiments give rise to standardized networks facilitating topological calculations ...
Long Lu +8 more
arxiv +4 more sources
Functional Characterization of Alternative and Classical Pathway C3/C5 Convertase Activity and Inhibition Using Purified Models [PDF]
Front Immunol, 2018 Complement is essential for the protection against infections; however, dysregulation of complement activation can cause onset and progression of numerous inflammatory diseases.
S. Zwarthoff +8 more
semanticscholar +2 more sources
Blood, 2018 The mechanisms by which exposure to heparin initiates antibody responses in many, if not most, recipients are poorly understood. We recently demonstrated that antigenic platelet factor 4 (PF4)/heparin complexes activate complement in plasma and bind to B
S. Khandelwal +12 more
semanticscholar +2 more sources
Systemic Lupus Erythematosus and Deficiencies of Early Components of the Complement Classical Pathway [PDF]
Front Immunol, 2016 The complement system plays an important role in the innate and acquired immune response against pathogens. It consists of more than 30 proteins found in soluble form or attached to cell membranes. Most complement proteins circulate in inactive forms and
A. C. Macedo, L. Isaac
semanticscholar +2 more sources
Complement-Coagulation Cross-talk: Factor H-mediated regulation of the Complement Classical Pathway activation by fibrin clots [PDF]
Frontiers in ImmunologyThe classical pathway of the complement system is activated by the binding of C1q in the C1 complex to the target activator, including immune complexes. Factor H is regarded as the key downregulatory protein of the complement alternative pathway. However,
Yu-Hoi Kang +7 more
doaj +2 more sources
Targeting the Initiator Protease of the Classical Pathway of Complement Using Fragment-Based Drug Discovery [PDF]
Molecules, 2020 The initiating protease of the complement classical pathway, C1r, represents an upstream and pathway-specific intervention point for complement-related autoimmune and inflammatory diseases.
Blake R. Rushing +4 more
doaj +2 more sources
Is there a classical nonsense-mediated decay pathway in trypanosomes? [PDF]
PLoS ONE, 2011 In many eukaryotes, messenger RNAs with premature termination codons are destroyed by a process called "nonsense-mediated decay", which requires the RNA helicase Upf1 and also, usually, an interacting factor, Upf2.
Praveen Delhi +4 more
doaj +5 more sources