The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection. [PDF]
PLoS Pathogens, 2012 The complement system plays a key role in host defense against pneumococcal infection. Three different pathways, the classical, alternative and lectin pathways, mediate complement activation.
Youssif M Ali +15 more
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Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma [PDF]
Mol Neurodegener, 2016 Glaucoma is a complex, multifactorial disease characterised by the loss of retinal ganglion cells and their axons leading to a decrease in visual function. The earliest events that damage retinal ganglion cells in glaucoma are currently unknown.
Pete A. Williams +8 more
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Activated complement classical pathway in a murine model of oxygen-induced retinopathy [PDF]
International Journal of Ophthalmology, 2015 AIM: To investigate whether the complement system is involved in a murine model of oxygen-induced retinopathy (OIR). METHODS: Forty C57BL/6J newborn mice were divided randomly into OIR group and control group. OIR was induced by exposing mice to 75%±2%
Xue-Ying Tao, Shi-Jie Zheng, Bo Lei
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Classical pathway complement activation in Kawasaki syndrome
Journal of Allergy and Clinical Immunology, 1994 In this study the complement breakdown products C3d, C4d, Bb and membrane attack complex were measured in plasma of patients with Kawasaki syndrome. The results suggested strong activation of the classical activation pathway. However, there was no significant decrease in hemolytic titer or in the concentrations of the intact proteins C3, C4, and B. The
Takao Kohsaka +3 more
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Designing novel construction for cell surface display of protein E on Escherichia coli using non-classical pathway based on Lpp-OmpA [PDF]
AMB Express, 2017 Today, transference of recombinant protein on the outer surface of bacteria is deemed as a valuable process for various applications in biotechnology including preparation of vaccines.
M. Jeiranikhameneh +4 more
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Frontiers in Immunology, 2018 Activation of the classical complement pathway occurs to varying degrees within strains of the Borrelia burgdorferi sensu lato complex, which contain a group of pathogenic spirochetes that cause tick-borne Lyme borreliosis, including the agent of Lyme ...
Hui Zhi, Jialei Xie, Jon T. Skare
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Discovery of a metabolic alternative to the classical mevalonate pathway
eLife, 2013 Eukarya, Archaea, and some Bacteria encode all or part of the essential mevalonate (MVA) metabolic pathway clinically modulated using statins. Curiously, two components of the MVA pathway are often absent from archaeal genomes.
Nikki Dellas +3 more
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Factor H as a regulator of the classical pathway activation.
Immunobiology, 2012 C1q, the first subcomponent of the classical pathway, is a charge pattern recognition molecule that binds a diverse range of self, non-self and altered self ligands, leading to pro-inflammatory complement activation. Although complement is required for tissue homeostasis as well as defence against pathogens, exaggerated complement activation can be ...
U. Kishore, Robert B Sim
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The phylogeny of the complement system and the origins of the classical pathway
Immunobiology, 2007 The origins of the complement system have now been traced to near to the beginnings of multi-cellular animal life. Most of the evidence points to the earliest activation mechanism having been more similar to the lectin pathway than to the alternative pathway.
Alister W. Dodds, Misao Matsushita
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Structure and activation of C1, the complex initiating the classical pathway of the complement cascade [PDF]
Proc Natl Acad Sci U S A, 2017 S. A. Mortensen +8 more
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