Results 21 to 30 of about 660,625 (335)
Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]
, 2010 Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Keeble, Anthony H. +4 more
core +1 more source
Frontiers in Immunology, 2018 The complement system is a tightly regulated network of proteins involved in defense against pathogens, inflammatory processes, and coordination of the innate and adaptive immune responses.
Cecilie E. Hertz +6 more
doaj +1 more source
Cytokine and Complement Response in the Glaucomatous βB1-CTGF Mouse Model
Frontiers in Cellular Neuroscience, 2021 Glaucoma is a complex neurodegenerative disease leading to a loss of retinal ganglion cells (RGCs) and optic nerve axons. An activation of the complement system seems to contribute to cell loss in this disease.
Sabrina Reinehr +6 more
doaj +1 more source
Direct versus Delayed pathways in Strong-Field Non-Sequential Double Ionization [PDF]
, 2010 We report full-dimensionality quantum and classical calculations for double ionization of laser-driven helium at 390 nm. Good qualitative agreement is observed.
A Emmanouilidou +7 more
core +2 more sources
Frontiers in Immunology, 2018 The immunopathological functions associated with human C1q are still growing in terms of novelty, diversity, and pathologic relevance. It is, therefore, not surprising that C1q is being recognized as an important molecular bridge between innate and ...
Berhane Ghebrehiwet +3 more
doaj +1 more source
Role of complement activation in anti-neutrophil cytoplasmic antibody-associated glomerulonephritis
Frontiers in Medicine, 2022 Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is an autoimmune disease characterized by necrotizing inflammation of small or medium vessels, causing ANCA associated glomerulonephritis (AAGN).
Tadasu Kojima, Takashi Oda
doaj +1 more source
Novel Evasion Mechanisms of the Classical Complement Pathway [PDF]
The Journal of Immunology, 2016 Abstract Complement is a network of soluble and cell surface-associated proteins that gives rise to a self-amplifying, yet tightly regulated system with fundamental roles in immune surveillance and clearance. Complement becomes activated on the surface of nonself cells by one of three initiating mechanisms known as the classical, lectin,
Brandon L Garcia +3 more
openaire +2 more sources
Frontiers in Immunology, 2021 Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in the western world. One of the treatments offered for CLL is immunotherapy.
Naseba Naseraldeen +16 more
doaj +1 more source
Dual pathway spindle assembly increases both the speed and the fidelity of mitosis [PDF]
, 2011 Roughly half of all animal somatic cell spindles assemble by the classical prophase pathway, in which the centrosomes separate ahead of nuclear envelope breakdown (NEBD).
Cross, R. A. +2 more
core +2 more sources
Multiple-Organ Complement Deposition on Vascular Endothelium in COVID-19 Patients
Biomedicines, 2021 Increased levels of circulating complement activation products have been reported in COVID-19 patients, but only limited information is available on complement involvement at the tissue level.
Paolo Macor +9 more
doaj +1 more source