Results 41 to 50 of about 4,411,154 (387)
Platelets, 2023 Increased platelet destruction is central in the pathogenesis of immune thrombocytopenia. However, impaired platelet production is also relevant and its significance underlies the rationale for treatment with thrombopoietin receptor agonists (TPO-RAs ...
Alexander Åkesson +7 more
doaj +1 more source
Role of complement activation in anti-neutrophil cytoplasmic antibody-associated glomerulonephritis
Frontiers in Medicine, 2022 Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is an autoimmune disease characterized by necrotizing inflammation of small or medium vessels, causing ANCA associated glomerulonephritis (AAGN).
Tadasu Kojima, Takashi Oda
doaj +1 more source
Cytokine and Complement Response in the Glaucomatous βB1-CTGF Mouse Model
Frontiers in Cellular Neuroscience, 2021 Glaucoma is a complex neurodegenerative disease leading to a loss of retinal ganglion cells (RGCs) and optic nerve axons. An activation of the complement system seems to contribute to cell loss in this disease.
Sabrina Reinehr +6 more
doaj +1 more source
Frontiers in Immunology, 2021 Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in the western world. One of the treatments offered for CLL is immunotherapy.
Naseba Naseraldeen +16 more
doaj +1 more source
Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes [PDF]
, 2007 CD38 controls the chemotaxis of leukocytes to some, but not all, chemokines, suggesting that chemokine receptor signaling in leukocytes is more diverse than previously appreciated.
Borchers, Michael T. +7 more
core +2 more sources
Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]
, 2010 Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Keeble, Anthony H. +4 more
core +1 more source
Complement in the Initiation and Evolution of Rheumatoid Arthritis
Frontiers in Immunology, 2018 The complement system is a major component of the immune system and plays a central role in many protective immune processes, including circulating immune complex processing and clearance, recognition of foreign antigens, modulation of humoral and ...
V. Michael Holers, Nirmal K. Banda
doaj +1 more source
Multiple-Organ Complement Deposition on Vascular Endothelium in COVID-19 Patients
Biomedicines, 2021 Increased levels of circulating complement activation products have been reported in COVID-19 patients, but only limited information is available on complement involvement at the tissue level.
Paolo Macor +9 more
doaj +1 more source
Frontiers in Immunology, 2019 C1q is the first subcomponent of the classical pathway of the complement system and belongs to the C1q/Tumor Necrosis Factor superfamily. C1q can perform a diverse range of immune and non-immune functions in a complement-dependent as well as -independent
Alessandro Mangogna +11 more
doaj +1 more source
Dual pathway spindle assembly increases both the speed and the fidelity of mitosis [PDF]
, 2011 Roughly half of all animal somatic cell spindles assemble by the classical prophase pathway, in which the centrosomes separate ahead of nuclear envelope breakdown (NEBD).
Cross, R. A. +2 more
core +2 more sources