Results 41 to 50 of about 660,625 (335)

Targeting the non-classical estrogen pathway in neurodegenerative diseases and brain injury disorders

Frontiers in Endocrinology, 2022
Estrogens can alter the biology of various tissues and organs, including the brain, and thus play an essential role in modulating homeostasis. Despite its traditional role in reproduction, it is now accepted that estrogen and its analogues can exert ...
Zsombor Koszegi, Rachel Y. Cheong
doaj   +1 more source

Classical analysis of correlated multiple ionization in strong fields

, 2000
We discuss the final stages of the simultaneous ionization of two or more electrons due to a strong laser pulse. An analysis of the classical dynamics suggests that the dominant pathway for non-sequential escape has the electrons escaping in a symmetric ...
Bruno Eckhardt, Krzysztof Sacha, Krzysztof Sacha   +2 more
core   +1 more source

Intertwined electron-nuclear motion in frustrated double ionization in driven heteronuclear molecules [PDF]

, 2017
We study frustrated double ionization in a strongly-driven heteronuclear molecule HeH$^{+}$ and compare with H$_2$. We compute the probability distribution of the sum of the final kinetic energies of the nuclei for strongly-driven HeH$^{+}$. We find that
Emmanouilidou, A., Jinzhen, Z., Scrinzi, A., Vilà, A.   +3 more
core   +2 more sources

Inflammasomes and Fibrosis

Frontiers in Immunology, 2021
Fibrosis is the final common pathway of inflammatory diseases in various organs. The inflammasomes play an important role in the progression of fibrosis as innate immune receptors.
Wen-Juan Zhang, Wen-Juan Zhang, Shu-Juan Chen, Shun-Chang Zhou, Su-Zhen Wu, Hui Wang   +5 more
doaj   +1 more source

Nucleation of colloids and macromolecules: does the nucleation pathway matter?

, 2012
A recent description of diffusion-limited nucleation based on fluctuating hydrodynamics that extends classical nucleation theory predicts a very non-classical two-step scenario whereby nucleation is most likely to occur in spatially-extended, low ...
Bernstein J., James F. Lutsko, Kashchiev D., Stranski I.   +3 more
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Classical complement pathway activation in membranoproliferative glomerulonephritis

Kidney International, 1976
Levels of components of the classical and alternative complement pathways and the activity of the C3 nephritic factor (C3NeF) were measured in serum specimens from patients with type I (subendothelial deposits) and type II (intramembranous dense deposits) membranoproliferative glomerulonephritis (MPGN) and the results compared with the levels in normal
Clark D. West, Enrique H. Vallota, Yuet M. Ooi   +2 more
openaire   +3 more sources

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways. [PDF]

, 2012
The NF-κB protein RelB controls dendritic cell (DC) maturation and may be targeted therapeutically to manipulate T cell responses in disease. Here we report that RelB promoted DC activation not as the expected RelB-p52 effector of the noncanonical NF-κB ...
Asagiri, Masataka, Davis-Turak, Jeremy, Fagerlund, Riku, Hoffmann, Alexander, Huang, Jenny Q, Kearns, Jeffrey D, Macal, Monica, Ponomarenko, Julia, Shih, Vincent F-S, Yu, Tony, Zuniga, Elina I   +10 more
core   +2 more sources