Results 1 to 10 of about 78,811 (306)

Testicular Gap (CX43) and Tight Junction (OCLN, CLDN3, 5 and 11) Components in the Dog Are Affected by GnRH-Mediated Downregulation [PDF]

Animals
Following the downregulation of testicular endocrine and germinative function by slow-release gonadotropin-releasing hormone (GnRH)-agonist implants, testicular functions are quickly restored after implant removal. As an intact blood–testis barrier (BTB)
Sandra Goericke-Pesch, Lena Röhrs, Sven Wallrabenstein, Agnete Frimødt Rønnow, Daniela Fietz, Ralph Brehm, Marion Langeheine, Axel Wehrend, Bernd Hoffmann, Hanna Körber, Eva-Maria Packeiser   +10 more
doaj   +2 more sources

Expression of Claudin-9 (CLDN9) in Breast Cancer, the Clinical Significance in Connection with Its Subcoat Anchorage Proteins ZO-1 and ZO-3 and Impact on Drug Resistance

Biomedicines, 2023
(1) Introduction: Claudin-9 (CLDN9) is a member of the claudin protein family, a critical transmembrane protein family for tight junctions that are implemented in the progression of numerous cancer types.
Xinguo Zhuang, Tracey A. Martin, Fiona Ruge, Jianyuan (Jimmy) Zeng, Xinyu (Amber) Li, Elyas Khan, Qingping Dou, Eleri Davies, Wen G. Jiang   +8 more
doaj   +1 more source

Claudin 6 is associated with a short survival and a short recurrent free interval in non-small cell lung carcinoma

Polish Journal of Pathology, 2022
We investigated the expression of claudin 6 in non-small-cell lung carcinomas (NSCLC) by immunohistochemistry. Samples of 164 patients with NSCLC were studied by immunohistochemistry. Claudin 6 was expressed in 42 % of cases.
Ylermi Soini, Risto Pirinen, Kumi Takasawa, Makoto Osanai, Akira Takasawa   +4 more
doaj   +1 more source

CDT of Clostridioides difficile Induces MLC-Dependent Intestinal Barrier Dysfunction in HT-29/B6 Epithelial Cell Monolayers

Toxins, 2023
Background: Clostridioides difficile binary toxin (CDT) defines the hypervirulence of strains in nosocomial antibiotic-induced colitis with the highest mortality.
Lucas Heils, Martina Schneemann, Ralf Gerhard, Jörg-Dieter Schulzke, Roland Bücker   +4 more
doaj   +1 more source

Context-Dependent Roles of Claudins in Tumorigenesis

Frontiers in Oncology, 2021
The barrier and fence functions of the claudin protein family are fundamental to tissue integrity and human health. Increasing evidence has linked claudins to signal transduction and tumorigenesis. The expression of claudins is frequently dysregulated in
Jian Li
doaj   +1 more source

VE-cadherin and claudin-5: it takes two to tango [PDF]

, 2008
Endothelial barrier function requires the adhesive activity of VE-cadherin and claudin-5, which are key components of adherens and tight endothelial junctions, respectively.
A Taddei, AS Yap, D Hoogeboom, E Dejana, J Gavard, J Rhee, J. Silvio Gutkind, Julie Gavard, MAG Essers, MG Lampugnani, P Carmeliet, R Paul, S Tsukita, S van Wetering, S Weis, T Nitta, VV Orlova, WJ Nelson   +17 more
core   +5 more sources

Human Claudin-7 cis-Interactions Are Not Crucial for Membrane-Membrane (Trans-) Interactions

Frontiers in Molecular Biosciences, 2022
Human Claudin-7 (Cldn7) is a member of the Claudin (Cldn) superfamily. In vivo, these proteins form tight junctions, which establish constricted connections between cells. Cldns oligomerize within the membrane plane (= cis-interaction), and also interact
Lena Ahlswede, Carmen Siebenaller, Benedikt Junglas, Nadja Hellmann, Dirk Schneider, Dirk Schneider   +5 more
doaj   +1 more source

Calcitriol modifies tight junctions, improves barrier function, and reduces TNF‐α‐induced barrier leak in the human lung‐derived epithelial cell culture model, 16HBE 14o‐

Physiological Reports, 2023
Using the 16HBE 14o‐ human airway epithelial cell culture model, calcitriol (Vitamin D) was shown to improve barrier function by two independent metrics – increased transepithelial electrical resistance (TER) and reduced transepithelial diffusion of 14C ...
Elizabeth Rybakovsky, Katherine M. DiGuilio, Mary Carmen Valenzano, Sophie Geagan, Kaithlyn Pham, Ronald N. Harty, James M. Mullin   +6 more
doaj   +1 more source

Tilivalline- and Tilimycin-Independent Effects of Klebsiella oxytoca on Tight Junction-Mediated Intestinal Barrier Impairment [PDF]

, 2019
Klebsiella oxytoca causes antibiotic-associated hemorrhagic colitis and diarrhea. This was attributed largely to its secreted cytotoxins tilivalline and tilimycin, inductors of epithelial apoptosis.
Bücker, Roland, Fromm, Anja, Fromm, Michael, Gorkiewicz, Gregor, Hering, Nina A., Högenauer, Christoph, Schulzke, Jörg-Dieter, Troeger, Hanno, Zechner, Ellen   +8 more
core   +1 more source

Developmental expression of claudins in the mammary gland [PDF]

, 2017
Claudins are a large family of membrane proteins whose classic function is to regulate the permeability of tight junctions in epithelia. They are tetraspanins, with four alpha-helices crossing the membrane, two extracellular loops, a short cytoplasmic N ...
Baumgartner, Heidi K., Bitler, Benjamin G., Burns, Valerie, Kobayashi, Ken, Neville, Margaret C., Ramanathan, Palaniappian, Rudolph, Michael C., Stein, Torsten, Webb, Patricia   +8 more
core   +1 more source