Results 101 to 110 of about 78,811 (306)

ORGAN SPECIFIC VASCULAR RESPONSE TO FIBROSIS AFFECTS BREAST CANCER METASTATIC ORGANOTROPISM [PDF]

, 2016
The solid tumor microenvironment, pre-metastatic niche, and fibrotic environment are known to have significant biochemical and biomechanical similarities to the fibrotic environment. All have significantly increased levels of factors such as TGFβ, HIF1α,
Fletcher, Eliot S, Fletcher, Eliot S
core   +1 more source

Cracking Piles of Brittle Grains

, 1998
A model which accounts for cracking avalanches in piles of grains subject to external load is introduced and numerically simulated. The stress is stochastically transferred from higher layers to lower ones.
C. C. Mounfield, C. Poirier, C.-H. Liu, D. Bideau, F. Radjai, František Slanina, G. A. Held, H. A. Makse, H. M. Jaeger, H.-M. Bröker, J. P. Wittmer, J. Šmíd, J.-P. Bouchaud, M. Marsili, M. Paczuski, P. Claudin, P. Claudin, P. Claudin, P. Evesque, P. Grassberger, Per Bak, S. F. Edwards, S. F. Edwards, S. N. Coppersmith, S. N. Coppersmith, S. Ouaguenouni, S. R. Nagel, S. Redner, S. Zapperi, T. Le Pennec, Z. Olami   +30 more
core   +1 more source

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

Dual Action of the PN159/KLAL/MAP Peptide: Increase of Drug Penetration across Caco-2 Intestinal Barrier Model by Modulation of Tight Junctions and Plasma Membrane Permeability

Pharmaceutics, 2019
The absorption of drugs is limited by the epithelial barriers of the gastrointestinal tract. One of the strategies to improve drug delivery is the modulation of barrier function by the targeted opening of epithelial tight junctions. In our previous study
Alexandra Bocsik, Ilona Gróf, Lóránd Kiss, Ferenc Ötvös, Ottó Zsíros, Lejla Daruka, Lívia Fülöp, Monika Vastag, Ágnes Kittel, Norbert Imre, Tamás A. Martinek, Csaba Pál, Piroska Szabó-Révész, Mária A. Deli   +13 more
doaj   +1 more source

Claudins in lung diseases [PDF]

Respiratory Research, 2011
Tight junctions are the most apically localized part of the epithelial junctional complex. They regulate the permeability and polarity of cell layers and create compartments in cell membranes. Claudins are structural molecules of tight junctions.
openaire   +3 more sources

Dietary Baicalin Supplementation Can Enhance the Growth Performance of Weaned Piglets and Maintain the Intestinal Barrier Integrity

Animal Research and One Health, EarlyView.
This research innovatively illustrates baicalin’s multifaceted mechanisms in enhancing piglets’ intestinal health: modulating bile acid metabolism via probiotics, reinforcing tight junction proteins (ZO‐1/claudin), suppressing TLR4/NF‐κB‐mediated inflammation, whereas promoting growth and reducing diarrhea.
Yuhui Gao, Jie Liu, Rui Yang, Xizhen Fan, Cheng Liang, Xin'e Shi, Jianjun Jin   +6 more
wiley   +1 more source

Tight junctional protein family, Claudins in cancer and cancer metastasis

Frontiers in Oncology
Claudin (CLDN) family proteins are key components of tight junctions in epithelial and endothelial cells, crucial for controlling paracellular permeability and cell-cell adhesion.
Wenxiao Ji, Xinguo Zhuang, Xinguo Zhuang, Wen G. Jiang, Tracey A. Martin   +4 more
doaj   +1 more source

Tight junction protein expression from peritoneal dialysis effluent

Renal Failure, 2019
Background: We hypothesized that tight junction (TJ) proteins may have a role in paracellular transport of solute and water in peritoneal dialysis (PD) patients.
Sua Kim, Eun Young Choi, Chor Ho Jo, Gheun-Ho Kim   +3 more
doaj   +1 more source

Sensitivity of the stress response function to packing preparation

, 2005
A granular assembly composed of a collection of identical grains may pack under different microscopic configurations with microscopic features that are sensitive to the preparation history.
, A P F Atman, Allen M P, Atman A P F, Behringer R P, Cates M E, Christoffersen J, da Silveira R Vidalenc G Gay C, E Clément, G Combe, G Reydellet, Gland N Wang P Makse H A, Goldenberg C, Goldenberg C, Head D A, Herrmann H J, J Geng, Kasahara A Nakanishi H, Liu C-h, Moreau J-J, Moukarzel C F, Ostojic S Panja D, Ostojic S Panja D, P Brunet, P Claudin, R P Behringer, Radjai F, Rothenburg L Selvadurai A P S, Roux J-N, Savage S, Schneebeli G, Serero D, Spannuth M J Mueggenburg N W Jaeger H M Nagel S R, Šmíd J   +33 more
core   +2 more sources

Claudins [PDF]

Current Biology, 2004
Peter, Yakov, Goodenough, Daniel
openaire   +2 more sources