Results 81 to 90 of about 78,811 (306)

Fermented Lacticaseibacillus Paracasei Cultures Ameliorate Colitis by Modulating Microbiota‐Derived Tryptophan Metabolism and Macrophage Polarization

Advanced Science, EarlyView.
A solid‐state fermented probiotic (PYW) is developed using wheat bran as substrate, containing high viable Lacticaseibacillus paracasei and bioactive metabolites. PYW alleviates intestinal inflammation by gut microbiota composition, enriching indole derivatives, activating aryl hydrocarbon receptor signaling, and regulating macrophage polarization. PYW
Heng Zhang, Jingzhou Sun, Xin Zheng, Huiqing Yang, Aowen Xie, Yuxuan Ding, Yuxia Mei, Jinshan Li, Yuanliang Hu, Min Ren, Yangyang Liu, Yunxiang Liang   +11 more
wiley   +1 more source

Stress response inside perturbed particle assemblies

, 2009
The effect of structural disorder on the stress response inside three dimensional particle assemblies is studied using computer simulations of frictionless sphere packings. Upon applying a localised, perturbative force within the packings, the resulting {
A. Tanguy, A.P.F. Atman, A.P.F. Atman, C. Eloy, C. Gay, C. Goldenberg, C. Goldenberg, C. Goldenberg, C. Goldenberg, C. Yi, C.F. Moukarzel, D. Bonamy, D.A. Head, F. Leonforte, F. Leonforte, G. Reydellet, H.M. Jaeger, I. Goldhirsch, J. Geng, J. Geng, J.E.S. Socolar, J.P. Bouchaud, J.P. Wittmer, K.L. Johnson, L. Breton, L.D. Landau, L.E. Silbert, Leonardo E. Silbert, M. Otto, M. Tsamados, M.D. Silva, M.J. Spannuth, N. Gland, N.W. Mueggenburg, P. Claudin, R. Blumenfeld, S. Ostojic, S.D.C. Walsh, S.N. Coppersmith, S.P. Timoshenko, V.M. Kenkre   +40 more
core   +2 more sources

Neuroprotective Effects of Time‐Restricted Feeding Combined With Different Protein Sources in MPTP‐Induced Parkinson's Disease Mice Model and Its Modulatory Impact on Gut Microbiota Metabolism

Advanced Science, EarlyView.
Time‐restricted feeding (TRF) exerts protein‐dependent neuroprotective effects in an MPTP‐induced Parkinson's disease model. In casein‐fed mice, TRF improves gut barrier integrity and reduces neuroinflammation, possibly via modulation of Allobaculum and BCAAs.
Ting Li, Jian Wu, Sheng‐Yang Zhou, Ming‐An Li, Li‐Ping Zhao, Ao Wang, Yi‐Zhi Song, Wen‐Yan Huang, Lu‐Lu Tan, Chen‐Meng Qiao, Wei‐Jiang Zhao, Chun Cui, Yan‐Qin Shen   +12 more
wiley   +1 more source

Stress response function of a two-dimensional ordered packing of frictional beads [PDF]

, 2002
We study the stress profile of an ordered two-dimensional packing of beads in response to the application of a vertical overload localized at its top surface.
Breton L., da Silveira R., Dantu P., Drogoul A., Eloy C., Goldenberg C., J.-D Zucker, Josselin de Jong G., L Breton, Moreau J.-J., Mueggenburg N. W., Otto M., P Claudin, Radjai F., Smíd J., É Clément   +15 more
core   +2 more sources

TOPK Inhibition Promotes Anti‐Tumor Immunity Via eIF4F Complex Mediated STAT1 Translation in Gastric Cancer

Advanced Science, EarlyView.
This study identifies TOPK as a dual‐function target in gastric cancer: it drives tumor cell proliferation and migration, and under IFN‐γ stimulation, phosphorylates eIF4F complex component eIF4A1 to enhance STAT1 mRNA translation, thereby promoting PD‐L1/IDO1‐mediated tumor immunometabolic evasion.
Junbing Chen, Longtao Huangfu, Gangjian Wang, Xueying Wang, Huanbo Zhu, Qian Yao, Cong Chen, Xiaohuan Tang, Ting Guo, Biao Fan, Xingyang Liu, Qingda Li, Zining Liu, Ying Hu, Tianze Sun, Jiafu Ji, Xiaofang Xing   +16 more
wiley   +1 more source

Plasma Levels of Occludin and Claudin-5 in Acute Stroke Are Correlated with the Type and Location of Stroke but Not with the Neurological State of Patients—Preliminary Data

Brain Sciences, 2020
The blood–brain barrier is the structure (BBB), which isolates the central nervous system from the external environmental. During a stroke, the BBB gets damaged, which is accompanied by changes in the concentrations and distributions of claudin-5 ...
Anetta Lasek-Bal, Anna Kokot, Daria Gendosz de Carrillo, Sebastian Student, Katarzyna Pawletko, Aleksandra Krzan, Przemysław Puz, Wiesław Bal, Halina Jędrzejowska-Szypułka   +8 more
doaj   +1 more source

Endothelial Cell‐Based Vascular Bandages for Blood–Brain Barrier Repair and Targeted siRNA Delivery

Advanced Science, EarlyView.
mECs restore blood–brain barrier function after cerebral ischemia–reperfusion by simultaneously targeting, supporting, and regulating the damaged vasculature. mECs home to injured cerebral vessels through interactions with highly expressed VLA‐4, reinforce endothelial integrity by forming new junctions, and, upon OGD‐SN treatment, acquire enhanced ...
Yaosheng Li, Yunfei Dong, Yaode He, Juanjuan Zheng, Hui Liu, Lu Li, Xiaoxu Hao, Yanli Zhao, Zefeng Yang, Yuankai Sun, Zhiwei Du, Bo Zhao, Weihang Zhou, Honghui Wu, Tianyuan Zhang, Jiahe Wu, Xiangrui Liu, Xianzhen Yin, Zhicai Chen, Rui Xue, Min Lou, Zhen Gu, Xinchi Jiang, Jianqing Gao   +23 more
wiley   +1 more source

HDAC3 regulates the diurnal rhythms of claudin expression and intestinal permeability

Frontiers in Epigenetics and Epigenomics
Circadian rhythms play an essential role in the regulation of intestinal absorption and barrier function. Tight junctions, including claudins, are fundamental components of the intestinal epithelial barrier.
Hunter Christopher, Jianglin Zhang, Sarah Olanrewaju Oladejo, Samskrathi Aravinda Sharma, Zheng Kuang   +4 more
doaj   +1 more source

Directed force chain networks and stress response in static granular materials

, 2002
A theory of stress fields in two-dimensional granular materials based on directed force chain networks is presented. A general equation for the densities of force chains in different directions is proposed and a complete solution is obtained for a ...
Claudin, P., Schaeffer, D. G., Socolar, J. E. S.   +2 more
core   +2 more sources

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source