Results 101 to 110 of about 20,395 (312)

Establishment of a Human Blood-Brain Barrier Co-culture Model Mimicking the Neurovascular Unit Using Induced Pluri- and Multipotent Stem Cells [PDF]

, 2017
Summary In vitro models of the human blood-brain barrier (BBB) are highly desirable for drug development. This study aims to analyze a set of ten different BBB culture models based on primary cells, human induced pluripotent stem cells (hiPSCs), and ...
Appelt-Menzel, Antje, Cubukova, Alevtina, Edenhofer, Frank, Günther, Katharina, Krause, Gerd [u.a.], Piontek, Jörg   +5 more
core   +1 more source

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

Role of the Blood-Brain Barrier in the Formation of Brain Metastases [PDF]

, 2013
The majority of brain metastases originate from lung cancer, breast cancer and malignant melanoma. In order to reach the brain, parenchyma metastatic cells have to transmigrate through the endothelial cell layer of brain capillaries, which forms the ...
Abbott, Ahn, Anfuso, Armulik, Aucoin, Aurrand-Lions, Balda, Barnhill, Bauer, Bos, Brayton, Brightman, Cangara, Carman, Chen, Cohen, Colone, Coussens, Cruz-Munoz, Csilla Fazakas, Cuevas, Daneman, Davies, Dejana, Deli, Denes, Douglas, Duenisch, Fabian, Fan, Farkas, Fidler, Fidler, Furuse, Furuse, Gay, Grinberg-Rashi, Gumbiner, Haskins, Hellstrom, Heon, Hicks, Holland, Hu, Hynes, Ilan, Imola Wilhelm, Inoko, István Krizbai, Izraely, Judit Molnár, János Haskó, Kacem, Khuon, Kienast, Kikuchi, Kim, Kim, Klein, Klein, Konstantopoulos, Krizbai, Krizbai, Krizbai, Krizbai, Krizbai, Lacaz-Vieira, Langer, Langley, Lecht, Lee, Lee, Lee, Li, Lin, Linger, Lockman, Longo, Lorger, Lorger, Lu, Maraveyas, Marchetti, Marchetti, Martin-Padura, Mendes, Mendes, Menter, Mierke, Neuwelt, Nguyen, Nicolson, Nishioku, Nitta, Ohtsuki, Oldendorf, Onodera, Ouban, Paku, Palmieri, Palmieri, Pardridge, Paspalas, Peng, Pestalozzi, Piontek, Platta, Qi, Qi, Reijerkerk, Ridgway, Rolland, Roy, Sahai, Sanz-Moreno, Savettieri, Seike, Shabani, Shimizu, Shintani, Sierra, Sims, Sipos, Stark, Stevenson, Stolp, Takeda, Takenaga, Tester, Tilling, Traweger, Wen, Wilhelm, Wilhelm, Wolburg, Wolf, Wong, Wu, Xie, Yoo, Yoshimasu, Zeljko, Zhang, Zhang, Zohrabian   +144 more
core   +2 more sources

Dietary Baicalin Supplementation Can Enhance the Growth Performance of Weaned Piglets and Maintain the Intestinal Barrier Integrity

Animal Research and One Health, EarlyView.
This research innovatively illustrates baicalin’s multifaceted mechanisms in enhancing piglets’ intestinal health: modulating bile acid metabolism via probiotics, reinforcing tight junction proteins (ZO‐1/claudin), suppressing TLR4/NF‐κB‐mediated inflammation, whereas promoting growth and reducing diarrhea.
Yuhui Gao, Jie Liu, Rui Yang, Xizhen Fan, Cheng Liang, Xin'e Shi, Jianjun Jin   +6 more
wiley   +1 more source

Traumatic Brain Injury Induces Genome-Wide Transcriptomic, Methylomic, and Network Perturbations in Brain and Blood Predicting Neurological Disorders. [PDF]

, 2017
The complexity of the traumatic brain injury (TBI) pathology, particularly concussive injury, is a serious obstacle for diagnosis, treatment, and long-term prognosis. Here we utilize modern systems biology in a rodent model of concussive injury to gain a
Agrawal, Rahul, Gomez-Pinilla, Fernando, Meng, Qingying, Yang, Xia, Ying, Zhe, Zhuang, Yumei   +5 more
core   +2 more sources

Claudins [PDF]

Current Biology, 2004
Peter, Yakov, Goodenough, Daniel
openaire   +2 more sources

Reduction of Ribonucleotide Reductase Subunit RRM2 Potentially Impairs Gut Function of Woody Breast Broilers

Animal Research and One Health, EarlyView.
Woody breast compromises meat quality leading to reduced consumer appeal. Although its causes are unclear, improvements observed with certain dietary supplements suggest that gut health may influence woody breast development. Ribonucleotide reductase subunit RRM2 is vital for mitochondrial function and gastrointestinal integrity, and alteration in its ...
Majid Shakeri, Elizabeth Ziabtchenko, Janghan Choi, Caitlin E. Harris, Richard J. Buhr, Trevor R. Mitchell, Byungwhi Kong, Hong Zhuang, Brian Bowker   +8 more
wiley   +1 more source

The Expression of the Claudin Family of Proteins in Colorectal Cancer

Biomolecules
Claudins (CLDN1–CLDN24) are a family of tight junction proteins whose dysregulation has been implicated in tumorigeneses of many cancer types. In colorectal cancer (CRC), CLDN1, CLDN2, CLDN4, and CLDN18 have been shown to either be upregulated or ...
Kristin E. Cox, Shanglei Liu, Robert M. Hoffman, Surinder K. Batra, Punita Dhawan, Michael Bouvet   +5 more
doaj   +1 more source

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease [PDF]

, 2009
The events that convert adherent epithelial cells into individual migratory cells that can invade the extracellular matrix are known collectively as epithelial-mesenchymal transition (EMT).
Akitaya, Alkhateeb, Andersson, Barrallo-Gimeno, Bertocchini, Chea, Ciruna, del Barrio, Dixon, Dottori, el Ghouzzi, Favier, Gans, Garcia-Castro, Giehl, Haraguchi, Hervé Acloque, Iwano, Johansson, Kalluri, Katherine Fishwick, Kitajima, Kos, Kwok, Liu, Liu, M. Angela Nieto, Manzanares, Marianne Bronner-Fraser, Martin, Mathieu, Meghan S. Adams, Moreno-Bueno, Nakagawa, Nakaya, Nieto, Peinado, Perea-Gomez, Perez-Pomares, Pijnenborg, Popperl, Sato, Sela-Donenfeld, Sela-Donenfeld, Selleck, Shah, Skromne, Tanimizu, Thiery, Varlet   +49 more
core   +3 more sources

Claudins and gastric carcinogenesis

Experimental Biology and Medicine, 2013
Gastric carcinoma arises from aberrant growth of normal gastric mucosa. There is increasing evidence that claudins (CLDNs) may play a critical role in the significant steps of gastric tumorigenesis, from metaplasia to metastasis. The CLDN family which consists of at least 27 member proteins is known to mediate selective permeability in cellular tight ...
Omid, Iravani, Benjamin Wei-Rong, Tay, Pei-Jou, Chua, George Wai-Cheong, Yip, Boon-Huat, Bay   +4 more
openaire   +2 more sources