Results 101 to 110 of about 20,415 (303)

Establishment of a Human Blood-Brain Barrier Co-culture Model Mimicking the Neurovascular Unit Using Induced Pluri- and Multipotent Stem Cells [PDF]

, 2017
Summary In vitro models of the human blood-brain barrier (BBB) are highly desirable for drug development. This study aims to analyze a set of ten different BBB culture models based on primary cells, human induced pluripotent stem cells (hiPSCs), and ...
Appelt-Menzel, Antje, Cubukova, Alevtina, Edenhofer, Frank, Günther, Katharina, Krause, Gerd [u.a.], Piontek, Jörg   +5 more
core   +1 more source

Claudins [PDF]

Current Biology, 2004
Peter, Yakov, Goodenough, Daniel
openaire   +2 more sources

Polydopamine‐Encapsulated Probiotics Restore Gut Homeostasis and Reinstate Macrophage Efferocytosis in Systemic Lupus Erythematosus

Advanced Science, EarlyView.
Polydopamine‐encapsulated probiotics restore gut homeostasis and reinstate macrophage efferocytosis, thereby reestablishing immune tolerance and mitigating systemic autoimmunity, highlighting a bioengineered microbiota‐based therapeutic strategy for SLE.
Ruimiao Wu, Mei Liu, Changxing Gao, Cheng Zhao, Feijie Zhao, Shuqing Dong, Bo Zhang, Qianmei Liu, Wenqian Zhang, Ming Zhao, Qianjin Lu   +10 more
wiley   +1 more source

The Expression of the Claudin Family of Proteins in Colorectal Cancer

Biomolecules
Claudins (CLDN1–CLDN24) are a family of tight junction proteins whose dysregulation has been implicated in tumorigeneses of many cancer types. In colorectal cancer (CRC), CLDN1, CLDN2, CLDN4, and CLDN18 have been shown to either be upregulated or ...
Kristin E. Cox, Shanglei Liu, Robert M. Hoffman, Surinder K. Batra, Punita Dhawan, Michael Bouvet   +5 more
doaj   +1 more source

Claudins and gastric carcinogenesis

Experimental Biology and Medicine, 2013
Gastric carcinoma arises from aberrant growth of normal gastric mucosa. There is increasing evidence that claudins (CLDNs) may play a critical role in the significant steps of gastric tumorigenesis, from metaplasia to metastasis. The CLDN family which consists of at least 27 member proteins is known to mediate selective permeability in cellular tight ...
Omid, Iravani, Benjamin Wei-Rong, Tay, Pei-Jou, Chua, George Wai-Cheong, Yip, Boon-Huat, Bay   +4 more
openaire   +2 more sources

Glucuronolactone Promotes Mucin Sulfation to Alleviate Deoxynivalenol‐Induced Intestinal Injury via Microbiota‐Dependent and ‐Independent AHR Activation

Advanced Science, EarlyView.
Glucuronolactone (GLU) as a natural metabolite of glucose, increases Lactobacillus amylovorus abundance and luminal IAA level to activate AHR signaling. In addition, GLU itself can directly elevate AHR signaling activity independently of microbiota and IAA.
Chenbin Cui, Beibei Zhang, Jiaxi Tang, Jing Hou, Yueqin Qiu, Kaiguo Gao, Li Wang, Zongyong Jiang, Xuefen Yang   +8 more
wiley   +1 more source

Chronic Helicobacter pylori-assotiated infection in children, paracellular permeability of the gastric mucosa and food allergy

Zdorovʹe Rebenka, 2019
Currently, issues related to tight junction dysfunction, are one of the most relevant and studied in scientific world. In spite of significant achievements, many problems are still open today.
O.E. Abaturov, A.E. Lykova
doaj   +1 more source

Claudin-containing exosomes in the peripheral circulation of women with ovarian cancer [PDF]

, 2009
Background The absence of highly sensitive and specific serum biomarkers makes mass screening for ovarian cancer impossible. The claudin proteins are frequently overexpressed in ovarian cancers, but their potential as prognostic, diagnostic, or detection
Jianghong Li, Cheryl A Sherman-Baust, Miyun Tsai-Turton, Robert E Bristow, Richard B Roden, Patrice J Morin, A Jemal, TI Goonewardene, RC Bast Jr, D Badgwell, EV Hogdall, S Skates, I Jacobs, U Menon, SS Buys, LJ Havrilesky, S Tsukita, PJ Morin, CD Hough, LBA Rangel, AD Santin, K Hibbs, VA Heinzelmann-Schwarz, KH Lu, E Bignotti, Y Zhu, YL Choi, L Kleinberg, P Michl, R Agarwal, G Sobel, P Dhawan, N Oku, Y Usami, PD Leotlela, T Oshima, YH Huang, GE Konecny, M Lechpammer, C Thery, F Andre, DD Taylor, F Andre, J Mallegol, K Koga, M Furlong, C Thery, GM Yousef, I Hellstrom, DG Rosen, G Mor, DD Taylor, S Runz, A Lakkaraju   +53 more
core   +2 more sources

Constraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy

Advanced Science, EarlyView.
This study constructed the W1/O/W2 emulsion–based targeted therapy delivery system for ulcerative colitis (UC) utilizing LCC as surfactant for the first time. This multifunctional emulsion offered certain therapeutic advantages for UC, including targeted colonic delivery of active compounds, synergistic modulation of gut microbiota through combined ...
Qian Wu, Xingyu Zhang, Jingjia Zhang, Gaohui Huang, Chen Zhou, Chunlin Li, Xiaojun Huang, Jianbo Xiao, Nianjie Feng, Yuanbin She   +9 more
wiley   +1 more source

Effects of Claudin-1 on the Action of Clostridium perfringens Enterotoxin in Caco-2 Cells

Toxins, 2019
Clostridium perfringens enterotoxin (CPE) contributes to diarrhea and an often-lethal enterotoxemia. CPE action starts when it binds to claudin receptors, forming a small complex (90 kDa). Six small complexes then oligomerize to create prepores, followed
Iman Mehdizadeh Gohari, Jihong Li, Mauricio Navarro, Francisco Uzal, Bruce McClane   +4 more
doaj   +1 more source