Results 181 to 190 of about 14,180 (293)

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Inulin as a Modulator of the Intestinal Barrier: Experimental Evidence, Mechanisms and Clinical Implications. [PDF]

Biomedicines
Martínez-Gopar PE, Guzmán-Mejía F, Godínez-Victoria M, Flores-Valente J, Molotla-Torres DE, Drago-Serrano ME.   +5 more
europepmc   +1 more source

Evolving Pathology of Anaplastic Thyroid Carcinoma: Integrating Morphology, Immunohistochemistry, and Molecular Insights

Cancer Science, EarlyView.
Schematic overview of progression from differentiated thyroid carcinoma (DTC) to anaplastic thyroid carcinoma (ATC). ATC primarily develops via two pathways: the BRAF p.V600E‐mutated papillary thyroid carcinoma (PTC) pathway and the RAS‐mutated pathway. The origin and progression of BRAF/RAS‐wildtype ATC remain unclear.
Toru Odate, Tetsuo Kondo
wiley   +1 more source

Control of renal calcium permeability via a tight junctional claudin switch. [PDF]

Proc Natl Acad Sci U S A
van der Veen RE, Bieck M, Mezouar N, Haucke V, Dimke H, Lehmann M.   +5 more
europepmc   +1 more source

Moesin, a Cytoskeletal‐Associated Protein, Outperforms Candidate Biomarkers in Identifying Asthma Exacerbation

Allergy, EarlyView.
Pureun‐Haneul Lee, SangMin Yoon, Cheolgi Lee, An‐Soo Jang   +3 more
wiley   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, EarlyView.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Interplay between volemic balance and the intestinal tract: insights on biomarkers and diagnostic tests used to assess intestinal morphofunctional barrier. [PDF]

Braz J Med Biol Res
Neto VLM, Araújo ICD, Rôla TBM, Magalhães PJC, Rodrigues FAP, Lima AAM, Santos AA.   +6 more
europepmc   +1 more source

Perineurioma‐like EMA‐positive calvarial neoplasms: clinicopathological study of eight cases

Histopathology, EarlyView.
Perineurioma‐like, EMA‐positive calvarial neoplasms (PLECN) are a rare group of intraosseous spindle cell tumours that demonstrate overlapping morphologic features of perineurioma and fibroblastic meningioma. These lesions tend to behave indolently but show a propensity for progressive growth.
Raheel Rizwan, Yingting Mok, Josephine K Dermawan, Alexandra Isaacson, Veronica Ulici, Scott E Kilpatrick, John D Reith, Gabrielle Yeaney, Hakan Ilaslan, Karen J Fritchie   +9 more
wiley   +1 more source

Claudins in ovarian cancer: emerging biomarkers and therapeutic targets. [PDF]

Tissue Barriers
Therachiyil L, Bhat AA, Uddin S.
europepmc   +1 more source

Unveiling the molecular profile of adenosquamous gallbladder carcinoma: characterization of a Caucasian cohort

Histopathology, EarlyView.
GBASCs are MMRp tumours, exhibiting minimal HER2 overexpression and elevated PD‐L1 expression compared to adenocarcinomas. Especially in metastatic and TP53‐wild type tumours, GBASCs can express CLDN18, albeit limited to the glandular component. Their genomic profile resembles that of adenocarcinomas with an enrichment in alterations on PIK3CA, PTEN ...
Jessica Gasparello, Valentina Angerilli, Mario Domenico Rizzato, Edoardo Maffii, Carlotta Ceccon, Matilde Callegarin, Marianna Sabbadin, Monia Niero, Luisa Toffolatti, Francesca Bergamo, Paola Parente, Luca Mastracci, Federica Grillo, Alessandro Vanoli, Paola Mattiolo, Claudio Luchini, Angelo Paolo Dei Tos, Umberto Cillo, Giacomo Zanus, Sara Lonardi, Matteo Fassan   +20 more
wiley   +1 more source