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Intestinal Barrier, Claudins and Mycotoxins
Toxins, 2021 The intestinal barrier is the main barrier against all of the substances that enter the body. Proper functioning of this barrier guarantees maintained balance in the organism. Mycotoxins are toxic, secondary fungi metabolites, that have a negative impact
Marta Justyna Kozieł +2 more
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Claudins: New Players in Human Fertility and Reproductive System Cancers
Cancers, 2020 Claudins are major integral proteins of tight junctions (TJs), the apical cell–cell adhesions that enable maintaining polarity of epithelial cells, their differentiation, and cell signaling.
Marta Justyna Kozieł +2 more
exaly +2 more sources
Expression of claudins in murine tooth development
Developmental Dynamics, 2007 Claudins belong to a family of transmembrane proteins that were identified as components of tight junction strands. We carried out comparative in situ hybridization analysis of 11 claudin genes (claudin1 - claudin11) during murine odontogenesis from the ...
Atsushi Ohazama, Paul T Sharpe
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Scandinavian Journal of Gastroenterology, 2013 Item does not contain fulltextBACKGROUND: Claudins, being part of the tight junction protein family, partially determine the integrity and paracellular permeability of the intestinal epithelium. The aim of this study was twofold.
Katri Kaukinen +2 more
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Cancers, 2023 Head and neck carcinomas have been associated with poor prognosis. Recent studies have highlighted the role of claudins’ expression in tumors throughout the body, and their prognostic and therapeutic role. Understanding the role of claudins and how
Tarek Ziad Arabi +2 more
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The Expression of Claudin-1, Claudin-2, Claudin-3, and Claudin-4 in Gastric Cancer Tissue
Journal of Surgical Research, 2011The claudins (CLDNs) are a family of functional tight junction proteins, and are involved with the epithelial-to-mesenchymal transition (EMT). The claudin proteins have a significant influence on the biological behavior of tumor progression in several types of cancers.
Hun, Jung +4 more
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The role of claudins in homeostasis
Nature Reviews Nephrology, 2023Sequential expression of claudins, a family of tight junction proteins, along the nephron mirrors the sequential expression of ion channels and transporters. Only by the interplay of transcellular and paracellular transport can the kidney efficiently maintain electrolyte and water homeostasis in an organism.
Luca Meoli, Dorothee Günzel
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Current Opinion in Nephrology and Hypertension, 2018
The greatest risk factor for kidney stone formation is increased urinary calcium excretion. Most filtered calcium is reabsorbed from the proximal tubule and the thick ascending limb (TAL) of Henle's loop via a paracellular pathway. Claudins are tight junction proteins that confer the permeability properties of an epithelium.
Allein, Plain, R Todd, Alexander
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The greatest risk factor for kidney stone formation is increased urinary calcium excretion. Most filtered calcium is reabsorbed from the proximal tubule and the thick ascending limb (TAL) of Henle's loop via a paracellular pathway. Claudins are tight junction proteins that confer the permeability properties of an epithelium.
Allein, Plain, R Todd, Alexander
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Cancer Research, 2011
Abstract Claudins are a family of proteins that are structural and functional components of tight junctions and have crucial roles in the maintenance of cellular arrangement, adhesion and paracellular transport. Recent studies have shown that changes and/or loss of claudin expression plays an important role in tumorigenesis and tumor ...
Adriana Bulgarelli +6 more
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Abstract Claudins are a family of proteins that are structural and functional components of tight junctions and have crucial roles in the maintenance of cellular arrangement, adhesion and paracellular transport. Recent studies have shown that changes and/or loss of claudin expression plays an important role in tumorigenesis and tumor ...
Adriana Bulgarelli +6 more
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Role of claudins in tumorigenesis
Advanced Drug Delivery Reviews, 2005The family of more than 20 claudin (CLDN) proteins comprises one of the major structural elements within the apical tight junction apparatus, a dynamic cellular nexus for maintenance of a luminal barrier, paracellular transport, and signal transduction. Loss of normal tight junction functions constitutes a hallmark of human carcinomas.
Karen, Swisshelm +2 more
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