Results 31 to 40 of about 209,174 (306)
Molecular Hybridization of Alkaloids Using 1,2,3-Triazole-Based Click Chemistry
Molecules, 2023 Alkaloids found in multiple species, known as ‘driver species’, are more likely to be included in early-stage drug development due to their high biodiversity compared to rare alkaloids.
Devan Buchanan +3 more
doaj +1 more source
Polysaccharides: The “Click” Chemistry Impact [PDF]
Polymers, 2011 Polysaccharides are complex but essential compounds utilized in many areas such as biomaterials, drug delivery, cosmetics, food chemistry or renewable energy. Modifications and functionalizations of such polymers are often necessary to achieve molecular structures of interest.
Elchinger, Pierre-Henri +6 more
openaire +2 more sources
Innovative Peptide Bioconjugation Chemistry with Radionuclides: Beyond Classical Click Chemistry
PharmaceuticalsBackground: The incorporation of radionuclides into peptides and larger biomolecules requires efficient and sometimes biorthogonal reaction conditions, to which click chemistry provides a convenient approach.
Samantha Leier, Frank Wuest
doaj +1 more source
Introduction: Click Chemistry [PDF]
Chemical Reviews, 2021 Neal K. Devaraj, M. G. Finn
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Antioxidants, 2020 To understand oxidative stress, antioxidant defense, and redox signaling in health and disease it is essential to assess protein thiol redox state. Protein thiol redox state is seldom assessed immunologically because of the inability to distinguish ...
James Nathan Cobley, Holger Husi
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Click chemistry for 3D bioprinting
Materials Horizons, 2023 Bioinks are employed in the fabrication of 3D scaffolds containing cells and macromolecules that can be applied in regenerative medicine.
Lei Nie +5 more
openaire +2 more sources
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Applications of Azide-Based Bioorthogonal Click Chemistry in Glycobiology
Molecules, 2013 Click chemistry is a powerful chemical reaction with excellent bioorthogonality features: biocompatible, rapid and highly specific in biological environments.
Xiu Zhang, Yan Zhang
doaj +1 more source