Biomacromolecules, 2019 Injectable hydrogels based on extracellular matrix-derived polymers show much promise in the field of tissue engineering and regenerative medicine. However, the hydrogels reported to date have at least one characteristic that limits their potential for ...
Justina Pupkaitė +3 more
semanticscholar +1 more source
Click histochemistry for whole-mount staining of brain structures
MethodsX, 2019 Labeling of the replicating DNA with synthetic thymidine analogs is commonly used for marking the dividing cells. However, until now this method has only been applied to histological sections.
Alexander A. Lazutkin +2 more
doaj +1 more source
Site Selective Antibody-Oligonucleotide Conjugation via Microbial Transglutaminase. [PDF]
, 2019 Nucleic Acid Therapeutics (NATs), including siRNAs and AntiSense Oligonucleotides (ASOs), have great potential to drug the undruggable genome. Targeting siRNAs and ASOs to specific cell types of interest has driven dramatic improvement in efficacy and ...
Cui, Xianshu +6 more
core +1 more source
Click-to-Chelate: Development of Technetium and Rhenium-Tricarbonyl Labeled Radiopharmaceuticals
Molecules, 2013 The Click-to-Chelate approach is a highly efficient strategy for the radiolabeling of molecules of medicinal interest with technetium and rhenium-tricarbonyl cores.
Thomas L. Mindt, Christiane A. Kluba
doaj +1 more source
Efficient click-addition sequence for polymer–polymer couplings [PDF]
, 2016 Controlled radical polymerization methods and click chemistry form a versatile toolbox for creating complex polymer architectures. However, the incompatibility between the functional groups required for click reactions and the reaction conditions of ...
Brendel, Johannes C. +2 more
core +1 more source
Experimental and Numerical Investigation on Progressive Collapse Resistance of Post-tensioned Precast Concrete Beam-Column Sub-assemblages [PDF]
, 2020 In this paper, four 1/2 scaled precast concrete (PC) beam-column sub-assemblages with high performance connection were tested under push-down loading procedure to study the load resisting mechanism of PC frames subjected to different column removal ...
Feng, D-C. +4 more
core +1 more source
“Click” reactions in polysaccharide modification [PDF]
Progress in Polymer Science, 2016 Abstract Polysaccharide chemistry is enjoying accelerating development thanks to advances in synthetic techniques, biochemistry and solvents, which enable polysaccharide materials to be useful in a variety of demanding applications. Among the synthetic advances, click chemistry has reconfigured the realm of polysaccharide modification that previously
Xiangtao Meng, Kevin J. Edgar
openaire +1 more source
Epidermal Growth Factor–PEG Functionalized PAMAM-Pentaethylenehexamine Dendron for Targeted Gene Delivery Produced by Click Chemistry [PDF]
, 2011 Aim of this study was the site-specific conjugation of an epidermal growth factor (EGF)-polyethylene glycol (PEG) chain by click chemistry onto a poly(amido amine) (PAMAM) dendron, as a key step toward defined multifunctional carriers for targeted gene ...
Balogh L. +59 more
core +1 more source
Acid-Labile Traceless Click Linker for Protein Transduction [PDF]
, 2012 Intracellular delivery of active proteins presents an interesting approach in research and therapy. We created a protein transduction shuttle based on a new traceless click linker that combines the advantages of click reactions with implementation of ...
Bachelder E. M. +21 more
core +1 more source
Click Chemistry: Reaction Rates and Their Suitability for Biomedical Applications
Bioconjugate chemistryClick chemistry has become a commonly used synthetic method due to the simplicity, efficiency, and high selectivity of this class of chemical reactions. Since their initial discovery, further click chemistry methods have been identified and added to the ...
T.-D. Luu +3 more
semanticscholar +1 more source