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The Clp Chaperones and Proteases of the Human Malaria Parasite Plasmodium falciparum
Journal of Molecular Biology, 2010The Clp chaperones and proteases play an important role in protein homeostasis in the cell. They are highly conserved across prokaryotes and found also in the mitochondria of eukaryotes and the chloroplasts of plants. They function mainly in the disaggregation, unfolding and degradation of native as well as misfolded proteins.
Majida, El Bakkouri +12 more
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Identifying new sequence markers for proteolysis by Escherichia coli Clp proteases
2020ATP-dependent proteases are large enzymatic complexes that catalyze the degradation of folded proteins in the cytosol. These proteases are ubiquitous in nature, being present in all domains of life. Whereas eukaryotic organisms generally possess a single centralized proteolytic complex, bacteria possess multiple separate ATP-dependent proteases, each ...
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Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival
Cell, 2023Farnusch Kaschani +2 more
exaly
[23] Endopeptidase Clp: ATP-dependent Clp protease from Escherichia coli
1994Michael R. Maurizi +3 more
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Endopeptidase Clp: ATP-dependent Clp protease from Escherichia coli.
Methods in enzymology, 1995M R, Maurizi +3 more
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