Results 71 to 80 of about 5,725 (156)

Lipid Nanoparticles Delivering ClpP‐mRNA Suppress Pyroptosis and Senescence in Intervertebral Disc Degeneration via mTOR/BNIP3‐Activated Mitophagy

Rare Metals, Volume 45, Issue 2, February 2026.
ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang, Zhiqiang Wang, Tong Zhang, Shicheng Qiu, Guang Yang, Yanzheng Gao, Xiaofeng Lian, Xin Peng   +7 more
wiley   +1 more source

Activators of Cylindrical Proteases as Antimicrobials: Identification and Development of Small Molecule Activators of ClpP Protease

Chemistry & Biology, 2011
ClpP is a cylindrical serine protease whose ability to degrade proteins is regulated by the unfoldase ATP-dependent chaperones. ClpP on its own can only degrade small peptides. Here, we used ClpP as a target in a high-throughput screen for compounds, which activate the protease and allow it to degrade larger proteins, hence, abolishing the specificity ...
Leung, Elisa, Datti, Alessandro, Cossette, Michele, Goodreid, Jordan, McCaw, Shannon E., Mah, Michelle, Nakhamchik, Alina, Ogata, Koji, El Bakkouri, Majida, Cheng, Yi-Qiang, Wodak, Shoshana J., Eger, Bryan T., Pai, Emil F., Liu, Jun, Gray-Owen, Scott, Batey, Robert A., Houry, Walid A.   +16 more
openaire   +2 more sources

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, Volume 600, Issue 1, Page 83-98, January 2026.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Ein Konformationsschalter ist für die Funktionsweise der Protease ClpP verantwortlich

Angewandte Chemie, 2011
„Atmendes“ Protein: Die erste Struktur des Virulenzregulators und Hitzeschockproteins ClpP aus Staphylococcus aureus mit einem bisher nicht beobachteten komprimierten Zustand des ClpP-Fasses wird vorgestellt. Das Umschalten der Konformation in einer „Henkelregion“ am aktiven Zentrum führt zum Schließen der aktiven Zentren und Öffnen der äquatorialen ...
Geiger, Sebastian R., Böttcher, Thomas, Sieber, Stephan A., Cramer, Patrick   +3 more
openaire   +2 more sources

ATF5‐Dependent GDF15 Expression Mediates Anesthesia‐Induced Neuroprotection Against Stroke

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Anesthesia‐induced preconditioning protects against perioperative stroke. By manipulating ATF5 in excitatory neurons, it is shown that anesthesia‐driven ATF5 upregulation activates the mitochondrial unfolded protein response (UPRmt) and elevates GDF15 expression.
Xianshu Ju, Tao Zhang, Jianchen Cui, Yulim Lee, Suho Lee, Ho Min Kim, Boohwi Hong, Jiho Park, Chul Hee Choi, Hyon‐Seung Yi, Jun Young Heo, Woosuk Chung   +11 more
wiley   +1 more source

Integrating Morphology and Chloroplast Genomics: A New East Asian Species of Aletris (Nartheciaceae) With Insights Into Regional Phylogeny and Evolution

Ecology and Evolution, Volume 16, Issue 1, January 2026.
Based on morphological and chloroplast phylogenomic analyses, we describe Aletris medogensis as a new species endemic to the eastern Himalayas. Comparative genomics revealed structural variations, hypervariable markers, and signatures of positive selection in key genes, providing robust evidence for species delimitation and insights into the ...
Xiong Li, Yong‐Ling Qiu, Jiang‐Tao Li, Bo Xu, Qi Yu, Wen‐Bin Ju   +5 more
wiley   +1 more source

Structural Characteristics, Comparative Analyses, and Conservation Significance of the Complete Chloroplast Genome of the Critically Endangered Lithocarpus yongfuensis (Fagaceae)

Ecology and Evolution, Volume 16, Issue 1, January 2026.
We assembled and annotated the complete chloroplast genome of L. yongfuensis. The genome structure, gene content, and phylogenetic relationships were analyzed, providing new insights into the species' evolutionary history. These findings offer valuable genomic resources for future studies on taxonomy, conservation, and molecular breeding of L ...
Fengzhi Gu, Lifang Yang
wiley   +1 more source

Drosophila protease ClpXP specifically degrades DmLRPPRC1 controlling mitochondrial mRNA and translation

Scientific Reports, 2017
ClpXP is the major protease in the mitochondrial matrix in eukaryotes, and is well conserved among species. ClpXP is composed of a proteolytic subunit, ClpP, and a chaperone-like subunit, ClpX. Although it has been proposed that ClpXP is required for the
Yuichi Matsushima, Yuta Hirofuji, Masamune Aihara, Song Yue, Takeshi Uchiumi, Laurie S. Kaguni, Dongchon Kang   +6 more
doaj   +1 more source

The Protein Chaperone ClpX Targets Native and Non-native Aggregated Substrates for Remodeling, Disassembly, and Degradation with ClpP

Frontiers in Molecular Biosciences, 2017
ClpX is a member of the Clp/Hsp100 family of ATP-dependent chaperones and partners with ClpP, a compartmentalized protease, to degrade protein substrates bearing specific recognition signals.
Christopher J. LaBreck, Shannon May, Marissa G. Viola, Joseph Conti, Jodi L. Camberg   +4 more
doaj   +1 more source

Protein degradation by a component of the chaperonin‐linked protease ClpP

Genes to Cells
AbstractIn cells, proteins are synthesized, function, and degraded (dead). Protein synthesis (spring) is important for the life of proteins. However, how proteins die is equally important for organisms. Proteases are secreted from cells and used as nutrients to break down external proteins. Proteases degrade unwanted and harmful cellular proteins.
Fumihiro Ishikawa, Michio Homma, Genzoh Tanabe, Takayuki Uchihashi   +3 more
openaire   +2 more sources