Results 81 to 90 of about 5,725 (156)

Pressure‐dependent adaptation strategies implied by the dissimilatory iron reducer Orenia metallireducens Z6

mLife, Volume 5, Issue 1, Page 122-125, February 2026.
Shuyi Li, Jiahao Pei, Jiasong Fang, Rulong Liu, Yuli Wei, Xianyu Huang, Guang Yang, Min Liu, Qin Lin, Robert R. Sanford, Hongbo Shao, Yongguang Jiang, Yidan Hu, Zhou Jiang, Qi Feng, Yu He, Chenxi Zhang, Yizhou Fan, Yiran Dong, Liang Shi   +19 more
wiley   +1 more source

Mycobacterium tuberculosis ClpP Proteases Are Co-transcribed but Exhibit Different Substrate Specificities

PLoS ONE, 2013
Caseinolytic (Clp) proteases are widespread energy-dependent proteases; the functional ATP-dependent protease is comprised of multimers of proteolytic and regulatory subunits. Mycobacterium tuberculosis has two ClpP proteolytic subunits (ClpP1 and ClpP2), with both being essential for growth in vitro. ClpP1 and clpP2 are arranged in an apparent operon;
Personne, Y, Brown, AC, Schuessler, DL, Parish, T   +3 more
openaire   +5 more sources

Chemical activation of mitochondrial ClpP to modulate energy metabolism of CD4+ T cell for inflammatory bowel diseases treatment

Cell Reports Medicine
Summary: Inflammatory bowel disease (IBD) is an autoimmune disorder, and despite the availability of multiple Food and Drug Administration (FDA)-approved therapies, current clinical needs remain unmet. In this study, we find that caseinolytic protease P (
Jiangnan Zhang, Yunhan Jiang, Dongmei Fan, Zhiqiang Qiu, Xinlian He, Song Liu, Linjie Li, Zhengyi Dai, Lidan Zhang, Ziyi Shu, Lili Li, Hu Zhang, Tao Yang, Youfu Luo   +13 more
doaj   +1 more source

Structural insights into ClpP protease side exit pore-opening by a pH drop coupled with substrate hydrolysis. [PDF]

EMBO J, 2022
Kim L, Lee BG, Kim M, Kim MK, Kwon DH, Kim H, Brötz-Oesterhelt H, Roh SH, Song HK.   +8 more
europepmc   +1 more source

Molecular Basis of ClpP Protease Activation by Small Molecules

The FASEB Journal, 2019
Bacterial ClpP is a highly conserved, self‐compartmentalizing, cylindrical serine protease required for maintaining cellular proteostasis. Acyldepsipeptides (ADEPs) and activators of self‐compartmentalized proteases (ACPs) are small molecules that cause the dysregulation and activation of ClpP, which leads to bacterial cell death ...
openaire   +1 more source

Molecular insights into the dynamic modulation of bacterial ClpP function and oligomerization by peptidomimetic boronate compounds

Scientific Reports
Bacterial caseinolytic protease P subunit (ClpP) is important and vital for cell survival and infectivity. Recent publications describe and discuss the complex structure–function relationship of ClpP and its processive activity mediated by 14 catalytic ...
Bruno Alves França, Sven Falke, Holger Rohde, Christian Betzel   +3 more
doaj   +1 more source

HSPA8-mediated stability of the CLPP protein regulates mitochondrial autophagy in cisplatin-resistant ovarian cancer cells

Acta Biochimica et Biophysica Sinica
Currently, platinum agents remain the mainstay of chemotherapy for ovarian cancer (OC). However, cisplatin (DDP) resistance is a major reason for chemotherapy failure.
Kou Xinxin, Yang Xiaoxia, Zhao Zheng, Li Lei   +3 more
doaj   +1 more source

Recent structural insights into the mechanism of ClpP protease regulation by AAA+ chaperones and small molecules. [PDF]

J Biol Chem, 2022
Mabanglo MF, Houry WA.
europepmc   +1 more source

Structure characterization and mechanism of angiotensin I-converting enzyme (ACE) inhibitory peptides modified by plastein reaction derived from tiger nut (Cyperus esculentus)

Frontiers in Sustainable Food Systems
The development of peptides derived from plants, which have potential anti-angiotensin converting enzyme (ACE) activity and other bioactivities, are of scientific interest.
Junhua Shi, Zhuo Yang, Ming Xu, Guogang Zhao, Yawen Gao, Hongyan Zheng, Ji Feng   +6 more
doaj   +1 more source

Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment

Pharmaceuticals
Diffuse intrinsic pontine glioma (DIPG), affecting children aged 4–7 years, is a rare, aggressive tumor that originates in the pons and then spreads to nearby tissue.
Morena Miciaccia, Francesca Rizzo, Antonella Centonze, Gianfranco Cavallaro, Marialessandra Contino, Domenico Armenise, Olga Maria Baldelli, Roberta Solidoro, Savina Ferorelli, Pasquale Scarcia, Gennaro Agrimi, Veronica Zingales, Elisa Cimetta, Simone Ronsisvalle, Federica Maria Sipala, Paola Loguercio Polosa, Cosimo Gianluca Fortuna, Maria Grazia Perrone, Antonio Scilimati   +18 more
doaj   +1 more source