Results 91 to 100 of about 3,073 (171)
Koyunlarda, CMAH geninin Neu5Gc sialik asidiyle ilişkisinin araştırılması
, 2022 Meat is a food source rich in nutrients that are essential for healthy human growth and development. Despite the fact that meat eating is now linked to disease including cancer, cardiovascular disease and diabetes, meat has played a crucial role in human evolution.
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Involvement of a Non-Human Sialic Acid in Human Cancer
Frontiers in Oncology, 2014 Sialic acids are common monosaccharides that are widely expressed as outer terminal units on all vertebrate cell surfaces, and play fundamental roles in cell-cell and cell-microenvironment interactions.
Annie eSamraj +3 more
doaj +1 more source
Cellular xenotransplantation of animal cells into people: benefits and risk [PDF]
, 2018 The main benefit of xenotransplantation is its potential to overcome the worldwide organ shortage experienced in allotransplantation. Allogeneic transplantation is the only successful therapy for several life-threatening diseases, with cell, tissue or ...
Cozzi, Emanuele +4 more
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Health Care Science, Volume 4, Issue 6, Page 377-380, December 2025.
Björn Nashan
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Xenotransplantation Literature Update: January–June 2025
Xenotransplantation, Volume 32, Issue 4, July/August 2025.ABSTRACT From January to June 2025, the field of xenotransplantation progressed rapidly toward clinical translation, with landmark compassionate‐use cases, peer‐reviewed reports of porcine kidney, heart, and liver transplants in humans, and the release of authoritative international guidelines.
Kasra Shirini +2 more
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Viable pigs after simultaneous inactivation of porcine MHC class I and three xenoreactive antigen genes GGTA1, CMAH and B4GALNT2 [PDF]
Xenotransplantation, 2019 AbstractBackgroundCell surface carbohydrate antigens play a major role in the rejection of porcine xenografts. The most important for human recipients are α‐1,3 Gal (Galactose‐alpha‐1,3‐galactose) causing hyperacute rejection, also Neu5Gc (N‐glycolylneuraminic acid) and Sd(a) blood group antigens both of which are likely to elicit acute vascular ...
Konrad Fischer +16 more
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Medicine Bulletin, Volume 1, Issue 1, Page 77-85, June 2025.Recent clinical trials transplanted gene‐edited pig hearts, kidneys, and a liver into eight human patients, demonstrating xenotransplantation's potential to address organ shortages. While showing promise, outcomes varied, highlighting key challenges including immune rejection and managing patient comorbidities, requiring further optimization.
Lisha Mou, Zuhui Pu, David K. C. Cooper
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Time‐Series Factor Modeling and Selection
Journal of Financial Research, Volume 48, Issue 2, Page 839-875, Summer 2025.Abstract The article proposes a statistical time‐series factor model that incorporates deterministic orthogonal trend polynomials. Such polynomials allow capturing variation in returns without initially identifying a set of robust time‐series factors.
Michael Michaelides
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PhysiologyObjective: Humans are unique among hominids in that they are endurance athletes. Inactivation of the CMP-Neu5Ac hydroxylase (CMAH) gene, which encodes a hydroxylase converting sialic acid Neu5Ac to Neu5Gc, is thought to contribute to this exceptional capacity for endurance running.
Al Dikka, Donivian +2 more
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Kafkas Universitesi Veteriner Fakultesi Dergisi, 2019 Neonatal isoerythrolysis is a life threatening disease in new born cats. It occurs when type A or type AB kittens are born from a type B queen (female cat). A homozygous 18 bp insertion located in cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) gene has been detected in type B cats, causing production of inactive CMAH enzyme ...
Atalay Şahar E. +7 more
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