Scientific Reports, 2021 Xenotransplantation (cross-species transplantation) using genetically-engineered pig organs offers a potential solution to address persistent organ shortage.
Ping Li +13 more
doaj +1 more source
Phylogenetic distribution of CMP-Neu5Ac hydroxylase (CMAH), the enzyme synthetizing the pro-inflammatory human xeno-antigen Neu5Gc [PDF]
, 2018 The enzyme CMP-N-acetylneuraminic acid hydroxylase (CMAH) is responsible for thesynthesis of N-glycolylneuraminic acid (Neu5Gc), a sialic acid present on the cell surfaceproteins of most deuterostomes.
Peri, Sateesh
core +2 more sources
Absence of Neu5Gc and Presence of Anti-Neu5Gc Antibodies in Humans—An Evolutionary Perspective
Frontiers in Immunology, 2019 The glycocalyx of human cells differs from that of many other mammals by the lack of the sialic acid N-glycolylneuraminic acid (Neu5Gc) and increased abundance of its precursor N-acetylneuraminic acid (Neu5Ac).
Meghan O. Altman +2 more
doaj +1 more source
Methodological Frameworks for Computational Electrocatalysis: From Theory to Practice
Small Methods, Volume 10, Issue 5, 9 March 2026.Computational modeling is widely used to investigate electrocatalytic reactions, yet accurately describing electrochemical interfaces remains challenging. This review outlines theoretical and computational strategies, based on density functional theory, to model reaction thermodynamics, solvation effects, applied bias, and kinetics.
Michele Re Fiorentin +8 more
wiley +1 more source
Analysis of cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) gene related to neonatal isoerythrolysis in stray cats of Izmir, Turkey [Türkiye, İzmir sokak kedilerinde neonatal izoeritrolizisle ilişkili sitidin monofosfat-N-asetilnöraminik asit hidroksilaz (CMAH) geninin analizi] [PDF]
, 2016 Neonatal isoerythrolysis is a life threatening disease in new born cats. It occurs when type A or type AB kittens are born from a type B queen (female cat).
Döşkaya M. +15 more
core +2 more sources
Involvement of a Non-Human Sialic Acid in Human Cancer
Frontiers in Oncology, 2014 Sialic acids are common monosaccharides that are widely expressed as outer terminal units on all vertebrate cell surfaces, and play fundamental roles in cell-cell and cell-microenvironment interactions.
Annie eSamraj +3 more
doaj +1 more source
Xenotransplantation, Volume 33, Issue 2, March/April 2026.ABSTRACT Background Severe thrombocytopenia and coagulation dysregulation remain major barriers to survival in pig‐to‐primate liver xenotransplantation models. Methods Porcine livers with five genetic modifications (GTKO, CMAHKO, β4GalNT2KO, hCD55, and hTBM) were orthotopically transplanted into four Tibetan macaques under two conventional ...
Zhongqiang Zhang +17 more
wiley +1 more source
EFSA Journal, Volume 24, Issue 2, February 2026.Abstract The European Food Safety Authority has issued several scientific opinions on plants, microorganisms and animals obtained through certain new genomic techniques (NGTs), following requests received by the European Commission. These scientific opinions provided considerations on the potential risks associated with NGTs, as compared to ...
European Food Safety Authority (EFSA) +12 more
wiley +1 more source
Germline transmission and genotypes of F1 CMAH KO piglets.
, 2019 Germline transmission and genotypes of F1 CMAH KO piglets.
Kai-Hsuan Hsiao (6751745) +11 more
core +1 more source
Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment [PDF]
, 2018 Duchenne muscular dystrophy (DMD) is caused by loss of dystrophin protein, leading to progressive muscle weakness and premature death due to respiratory and/or cardiac complications.
Betts, C A +34 more
core +1 more source