Results 81 to 90 of about 2,006 (151)

Organ Transplantation: Current Status, Challenges, and Future Prospects

MedComm, Volume 7, Issue 1, January 2026.
Organ transplantation success relies on precise modulation of the alloimmune response across distinct temporal phases of rejection. Hyperacute rejection results from preformed antibodies activating complement and causing thrombosis, while acute rejection involves T cell‐ and antibody‐mediated mechanisms that drive endothelial activation and ...
Xinqiang Li, Ruidong Ding, Jinzhen Cai
wiley   +1 more source

Striking Immune Phenotypes in Gene-Targeted Mice Are Driven by a Copy-Number Variant Originating from a Commercially Available C57BL/6 Strain

Cell Reports, 2016
We describe a homozygous copy-number variant that disrupts the function of Dock2 in a commercially available C57BL/6 mouse strain that is widely used for backcrossing.
Vinay S. Mahajan, Ezana Demissie, Hamid Mattoo, Vinay Viswanadham, Ajit Varki, Robert Morris, Shiv Pillai   +6 more
doaj   +1 more source

Toward a New Era: Major Advancements and Future Perspectives in Organ Medicine

Organ Medicine, Volume 3, Issue 1, Page 1-4, March 2026.
Yuanwei Shi, Qiang Zhao, Xiaoshun He
wiley   +1 more source

Porcine to Human Heart Transplantation: Is Clinical Application Now Appropriate?

Journal of Immunology Research, 2017
Cardiac xenotransplantation (CXTx) is a promising solution to the chronic shortage of donor hearts. Recent advancements in immune suppression have greatly improved the survival of heterotopic CXTx, now extended beyond 2 years, and life-supporting kidney ...
Christopher G. A. McGregor, Guerard W. Byrne   +1 more
doaj   +1 more source

Chimeric antigen receptor T cells targeting the GM3(Neu5Gc) ganglioside

Frontiers in Immunology
Chimeric antigen receptor (CAR) T cell technology has ushered in a new era of immunotherapy, enabling the targeting of a broad range of surface antigens, surpassing the limitations of traditional T cell epitopes.
Julia Heinzelbecker, Julia Heinzelbecker, Marte Fauskanger, Ida Jonson, Ute Krengel, Geir Åge Løset, Geir Åge Løset, Ludvig Munthe, Anders Tveita, Anders Tveita   +9 more
doaj   +1 more source

Inhibiting T-Cell-Mediated Rejection of the Porcine Meniscus Through Freeze-Thawing and Downregulating Porcine Xenoreactive Antigen Genes

Cell Transplantation
Immune rejection presents a significant challenge in xenogenic meniscal transplantation. Pigs are widely regarded as an advantageous tissue source for such transplants, with porcine GGTA1, CMAH, and B4GALNT2 being among the most common xenoreactive ...
Rao Chen, Hailong Zhao, Liya Ai, Jiying Zhang, Dong Jiang   +4 more
doaj   +1 more source

Amino acid substitutions in diplotypes and inferred haplotypes in cat’s CMAH gene.

, 2016
Amino acid substitutions in diplotypes and inferred haplotypes in cat’s CMAH gene.
Shigenori Ikemoto (3226944), Chihiro Udagawa (3226941), Shota Nakazawa (3226932), Kazuhiko Ochiai (128430), Toshinori Sako (3226950), Azusa Gin (3226920), Toshihiko Tsutsui (3226911), Naomi Tada (3226914), Atsushi Sakamoto (695822), Toshinori Omi (430385), Makoto Bonkobara (3226917), Hitomi Oda (3226926), Kyoichi Tamura (3226929), Hiroko Mitsui (3226938), Yong Hwa Chong (3226923), Shuichi Tsuchida (430384), Yuiko Kato (3226947), Daigo Azakami (3226935), Takeshi Inagaki (3226908)   +18 more
core   +1 more source

Comparison of CMAH cDNA variants in cats with blood types A, B and AB.

, 2018
Comparison of CMAH cDNA variants in cats with blood types A, B and AB.
Nicholas A. Gustafson (3172212), Janling Cheng (3172209), Eva Spada (3172203), Badri Adhikari (3172206), Gordon Andrews (3172215), Daniela Proverbio (3172218), Chris R. Helps (106693), Leslie A. Lyons (106603), Robert A. Grahn (106581), Barbara Gandolfi (106586)   +9 more
core   +1 more source

Sialic acid characteristics of sera from WT and Cmah-KO Mice. A.

, 2013
DMB-HPLC analysis of mouse sera confirms that WT is Neu5Gc-positive while Cmah-KO is Neu5Gc-deficient. B. Lectin binding on mouse sera demonstrates both Siaα2-6 (SNA) and Siaα2-3 (MAL1/2) glycoconjugates in both WT and Cmah-KO.
Hai Yu (366836), Jane C. Burns (268128), Vered Padler-Karavani (375363), Adriana H. Tremoulet (387274), Ajit Varki (375367), Xi Chen (35903)   +5 more
core   +1 more source

Gene expression profile in the lung, kidney, and heart of Cmah null mice.

, 2014
A. Venn diagram showing differential expression of genes in the lung, kidney, and heart of Cmah null mice. Numbers in red and blue Venn diagram present up- and down- regulated genes, respectively. LU, lung; KI, kidney; HE, heart. B. The differentially up-
Byung-Soo Chang (630761), Deug-Nam Kwon (630760), Jin-Hoi Kim (577191)   +2 more
core   +1 more source