Results 81 to 90 of about 3,073 (171)
Preclinical Evaluation of Long-Acting Emtricitabine Semi-Solid Prodrug Nanoparticle Formulations
Pharmaceutics, 2023 Long-acting injectable (LAI) formulations promise to deliver patient benefits by overcoming issues associated with non-adherence. A preclinical assessment of semi-solid prodrug nanoparticle (SSPN) LAI formulations of emtricitabine (FTC) is reported here.
Paul Curley +16 more
doaj +1 more source
The role of genetically engineered pigs in xenotransplantation research [PDF]
, 2015 There is a critical shortage in the number of deceased human organs that become available for the purposes of clinical transplantation. This problem might be resolved by the transplantation of organs from pigs genetically engineered to protect them from ...
Ayares, David +4 more
core +1 more source
Uniquely human CHRFAM7A gene increases the hematopoietic stem cell reservoir in mice and amplifies their inflammatory response. [PDF]
, 2019 A subset of genes in the human genome are uniquely human and not found in other species. One example is CHRFAM7A, a dominant-negative inhibitor of the antiinflammatory α7 nicotinic acetylcholine receptor (α7nAChR/CHRNA7) that is also a neurotransmitter ...
Baird, Andrew +7 more
core
Estimation of algal growth parameters from vertical primary production profiles [PDF]
, 1981 Phytoplankton maximum growth rate and the saturation light intensity, Is, can be estimated from vertical profiles of primary production by non-linear least-squares estimation.
Herodek, Sandor, Straten, Gerrit van
core +2 more sources
Advanced Science, Volume 12, Issue 38, October 13, 2025.This study presents a comprehensive data mining strategy for in‐depth extraction of overall and altered glycan features from structural and site‐specific glycoproteome data across various biomedical samples. The strategy enables the uncovery of four major altered glycan features associated with thymic involution and reveals their coordinated ...
Zhida Zhang +11 more
wiley +1 more source
Scientific Reports, 2021 Xenotransplantation (cross-species transplantation) using genetically-engineered pig organs offers a potential solution to address persistent organ shortage.
Ping Li +13 more
doaj +1 more source
Expression of NeuGc on Pig Corneas and Its Potential Significance in Pig Corneal Xenotransplantation [PDF]
, 2016 PURPOSE: Pigs expressing neither galactose-α1,3-galactose (Gal) nor N-glycolylneuraminic acid (NeuGc) take xenotransplantation one step closer to the clinic. Our aims were (1) to document the lack of NeuGc expression on corneas and aortas and cultured
Ayares, David +10 more
core +1 more source
Loss of CMAH during Human Evolution Primed the Monocyte–Macrophage Lineage toward a More Inflammatory and Phagocytic State [PDF]
The Journal of Immunology, 2017 Abstract Humans and chimpanzees are more sensitive to endotoxin than are mice or monkeys, but any underlying differences in inflammatory physiology have not been fully described or understood. We studied innate immune responses in Cmah−/− mice, emulating human loss of the gene encoding production of Neu5Gc, a major cell surface sialic ...
Jonathan J Okerblom +8 more
openaire +4 more sources
Pre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model [PDF]
, 2015 Xenotransplantation has the potential to alleviate the organ shortage that prevents many patients with end-stage renal disease from enjoying the benefits of kidney transplantation.
Adams, Andrew B +12 more
core +1 more source
Biotechnology Journal, Volume 20, Issue 7, July 2025.Graphical Abstract and Lay Summary Transcriptomic analysis of CHO cells exposed to different industrially relevant conditions identified cholesterol and p53‐related genes with differential expression and several new housekeeping genes. ABSTRACT Chinese hamster ovary (CHO) cells are widely used in recombinant biopharmaceutical production; yet, yields ...
Benjamin F. Synoground +6 more
wiley +1 more source