Results 91 to 100 of about 96,622 (267)

Non-salt based co-amorphous formulation produced by freeze-drying

International Journal of Pharmaceutics, 2023
Amino acids-based co-amorphous system (CAM) has shown to be a promising approach to overcome the dissolution challenge of biopharmaceutics classification system class II drugs. To date, most CAM formulations are based on salt formation at a 1:1 M ratio and are prepared by mechanical activation.
Mohammed Suleiman Alsalhi, Paul G. Royall, Hisham Al-Obaidi, Alyaa Alsalhi, Agostino Cilibrizzi, Ka Lung Andrew Chan   +5 more
openaire   +3 more sources

Revisiting Stability Criteria in Ball‐Milled High‐Entropy Alloys: Do Hume–Rothery and Thermodynamic Rules Equally Apply?

Advanced Engineering Materials, Volume 27, Issue 6, March 2025.
The stability criteria affecting the formation of high‐entropy alloys, particularly focusing in supersaturated solid solutions produced by mechanical alloying, are analyzed. Criteria based on Hume–Rothery rules are distinguished from those derived from thermodynamic relations. The formers are generally applicable to mechanically alloyed samples.
Javier S. Blázquez, Alejandro F. Manchón‐Gordón, Antonio Vidal‐Crespo, Rafael Caballero‐Flores, Jhon J. Ipus, Clara F. Conde   +5 more
wiley   +1 more source

Efflux Inhibitor Bicalutamide Increases Oral Bioavailability of the Poorly Soluble Efflux Substrate Docetaxel in Co-Amorphous Anti-Cancer Combination Therapy

Molecules, 2019
Many anti-cancer drugs are difficult to formulate into an oral dosage form because they are both poorly water-soluble and show poor permeability, the latter often as a result of being an intestinal efflux pump substrate.
Adam Bohr, Thais Leite Nascimento, Necati Harmankaya, Johan Juhl Weisser, Yingya Wang, Holger Grohganz, Thomas Rades, Korbinian Löbmann   +7 more
doaj   +1 more source

Thermoreflectance Detection of Point Defects Resulting from Focused Ion Beam Milling

Advanced Engineering Materials, EarlyView.
Focused ion beam (FIB) milling is a common tool for nanoscale material processing, however irradiation damage, redeposition, and contamination can occur. We use several characterization tools to show FIB‐induced effects beyond 1 mm from the milled area.
Thomas W. Pfeifer, Eric R. Hoglund, Anton V. Ievlev, Patrick E. Hopkins   +3 more
wiley   +1 more source

Harnessing Fungal Biowelding for Constructing Mycelium‐Engineered Materials

Advanced Engineering Materials, EarlyView.
Mycelium‐bound composites (MBCs) offer low‐carbon alternatives for construction, yet interfacial bonding remains a critical challenge. This review examines fungal biowelding as a biocompatible adhesive, elucidating mycelium‐mediated interfacial mechanisms and their role in material assembly. Strategies to optimize biowelding are discussed, highlighting
Xue Brenda Bai, Xinrui Sarah Niu, Zhao Qin   +2 more
wiley   +1 more source

Generation of High Dose Inhalable Effervescent Dispersions against Pseudomonas aeruginosa Biofilms [PDF]

, 2020
Purpose: Novel particle engineering approach was used in this study to generate high dose inhalable effervescent particles with synergistic effects against Pseudomonas aeruginosa biofilms. Methods: Spray dried co-amorphous salt of ciprofloxacin (CFX) and
Al-Kassimy, Hareir, Al-Kassimy, Hareir, Al-Obaidi, H., Al-Obaidi, H., Ferraz, Amina, Ferraz, Amina, Hawkins, Nicholas, Hawkins, Nicholas, Houacine, Chahinez, Houacine, Chahinez, Kalgudi, Rachith, Kalgudi, Rachith, Madueke, Somto, Madueke, Somto, Mohammed, Aram, Mohammed, Aram, Yaqoob, Muhammad, Yaqoob, Muhammad, Zariwala, Mohammed Gulrez, Zariwala, Mohammed Gulrez, Zurek, Jakub, Zurek, Jakub   +21 more
core   +3 more sources

Low‐Cost, Large‐Scale Nanoporous Metals by Mechanical Alloying, Oxide Reduction, and Dealloying of Powders

Advanced Engineering Materials, EarlyView.
Powder metal processing provides scalable advantages in nanoporous (np) metal development. Mechanical alloying is used to produce unique precursors for hybrid nanopore formation by oxide reduction and dealloying. As demonstrated in np Ag, this approach improves process efficiency while promoting smaller ligaments and larger pores, both of which are ...
Mark A. Atwater, Oliver A. Fowler
wiley   +1 more source

Downstream processing of co-amorphous olanzapine [PDF]

, 2021
of poster presented at the 12th PBP World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Wien, Austria, 11-14 May 2021 (virtual meeting)N/
Costa, Nuno F. da, Fernandes, A.I., Pinto, João F.   +2 more
core  

Co-Amorphous Combination of Nateglinide-Metformin Hydrochloride for Dissolution Enhancement [PDF]

AAPS PharmSciTech, 2015
The aim of the present work was to prepare a co-amorphous mixture (COAM) of Nateglinide and Metformin hydrochloride to enhance the dissolution rate of poorly soluble Nateglinide. Nateglinide (120 mg) and Metformin hydrochloride (500 mg) COAM, as a dose ratio, were prepared by ball-milling technique.
Sarika Wairkar, Ram Gaud
openaire   +2 more sources

Electrochemical Evaluation of Compressed Selective Laser Melted AlSi7Mg and AlSi10Mg Alloys in Chloride Environment

Advanced Engineering Materials, EarlyView.
The corrosion performance of AlSi7Mg and AlSi10Mg alloys produced through selective laser melting (SLM) was examined under compressive stress in a chloride environment. Electrochemical analyses, including open‐circuit potential (OCP), potentiodynamic polarization (CPP), and electrochemical impedance spectroscopy (EIS), were complemented by scanning ...
Femi John Akinfolarin, Samson Dare Oguntuyi, Peter Apata Olubambi   +2 more
wiley   +1 more source