Results 11 to 20 of about 69,822 (254)

Randomized, double-blind, placebo-controlled trial to assess the efficacy and safety of three doses of co-suspension delivery technology glycopyrronium MDI in Japanese patients with moderate-to-severe COPD [PDF]

International Journal of COPD, 2018
Yasushi Fukushima,1 Yuji Nakatani,2 Yumiko Ide,3 Hisakuni Sekino,4 Earl St Rose,5 Shahid Siddiqui,6 Andrea Maes,5 Colin Reisner5,6 1Department of Internal Medicine, Fukuwa Clinic, Tokyo, Japan; 2Department of Internal Medicine, Nakatani Hospital, Hyogo,
Fukushima Y, Nakatani Y, Ide Y, Sekino H, St Rose E, Siddiqui S, Maes A, Reisner C   +7 more
doaj   +6 more sources

A randomized study using functional respiratory imaging to characterize bronchodilator effects of glycopyrrolate/formoterol fumarate delivered by a metered dose inhaler using co-suspension delivery technology in patients with COPD [PDF]

International Journal of COPD, 2018
Wilfried De Backer,1 Jan De Backer,2 Wim Vos,3 Ilse Verlinden,3 Cedric Van Holsbeke,3 Johan Clukers,1 Bita Hajian,1 Shahid Siddiqui,4 Martin Jenkins,5 Colin Reisner,4,6 Ubaldo J Martin4 1Department of Respiratory Medicine, University of Antwerp ...
De Backer W, De Backer J, Vos W, Verlinden I, Van Holsbeke C, Clukers J, Hajian B, Siddiqui S, Jenkins M, Reisner C, Martin UJ   +10 more
doaj   +7 more sources

Gamma scintigraphic pulmonary deposition study of glycopyrronium/formoterol metered dose inhaler formulated using co-suspension delivery technology [PDF]

European Journal of Pharmaceutical Sciences, 2017
This gamma scintigraphy imaging study was the first to assess pulmonary and extrathoracic deposition and regional lung deposition patterns of a radiolabelled long-acting muscarinic antagonist/long-acting β2-agonist fixed-dose combination glycopyrronium ...
Usmani, Omar S, Orevillo, Chad, Dwivedi, Sarvajna, Lauren Mello, Sarvajna Dwivedi, Ubaldo J. Martin, Andrea Maes, Omar S. Usmani, Glyn Taylor, Mark Sommerville, Chad Orevillo, Taylor, Glyn, Warren, Simon, Maes, Andrea, Simon Warren, Mello, Lauren, Sommerville, Mark, Martin, Ubaldo J   +17 more
core   +4 more sources

Consistent Pulmonary Drug Delivery with Whole Lung Deposition Using the Aerosphere Inhaler: A Review of the Evidence

International Journal of COPD, 2021
Omar S Usmani,1 Nicolas Roche,2 Martin Jenkins,3 Neda Stjepanovic,4 Peter Mack,5 Wilfried De Backer6 1National Heart and Lung Institute (NHLI), Imperial College London, and Royal Brompton Hospital, London, UK; 2Respiratory Medicine, Cochin Hospital ...
Usmani OS, Roche N, Jenkins M, Stjepanovic N, Mack P, De Backer W   +5 more
doaj   +1 more source

Pharmacokinetics of Co-Suspension Delivery Technology Budesonide/Glycopyrronium/Formoterol Fumarate Dihydrate (BGF MDI) and Budesonide/Formoterol Fumarate Dihydrate (BFF MDI) Fixed-Dose Combinations Compared With an Active Control: A Phase 1, Randomized, Single-Dose, Crossover Study in Healthy Adults. [PDF]

Clin Pharmacol Drug Dev, 2019
Maes A, DePetrillo P, Siddiqui S, Reisner C, Dorinsky P.   +4 more
europepmc   +2 more sources

Efficacy and Safety of Glycopyrrolate/Formoterol Metered Dose Inhaler Formulated Using Co-Suspension Delivery Technology in Patients With COPD [PDF]

Chest, 2017
Long-acting muscarinic antagonist (LAMA)/long-acting β2-agonist (LABA) combinations are a treatment option for patients with COPD who continue to have symptoms despite treatment with a LAMA or a LABA alone. The Efficacy and Safety of PT003, PT005, and PT001 in Subjects with Moderate-to-Very Severe COPD (PINNACLE-1) (NCT01854645) and the Multi-Center ...
Martinez, Fernando J., Rabe, Klaus F., Ferguson, Gary T., Fabbri, Leonardo M., Rennard, Stephen, Feldman, Gregory J., Sethi, Sanjay, Spangenthal, Selwyn, Gottschlich, Gregory M., Rodriguez-Roisin, Roberto, Arora, Samir, Siler, Thomas M., Siddiqui, Shahid, Darken, Patrick, Fischer, Tracy, Maes, Andrea, Golden, Michael, Orevillo, Chad, Reisner, Colin   +18 more
openaire   +4 more sources

Inhalable aerosol microparticles with low carrier dosage and high fine particle fraction prepared by spray-freeze-drying

International Journal of Pharmaceutics: X, 2023
Co-suspension drug-loading technology, namely Aerosphere™, can improve fine particle fraction (FPF) and delivered dose content uniformity (DDCU). However, because of its poor drug-loading efficacy, the phospholipid carrier dosage in Aerosphere™ is ...
Quan Xi, Jiaying Miao, Zhen Cao, Hao Wang   +3 more
doaj   +1 more source

Dose-Ranging and Cumulative Dose Studies of Albuterol Sulfate MDI in Co-Suspension Delivery™ Technology (AS MDI; PT007) in Patients with Asthma: the ASPEN and ANTORA Trials [PDF]

Clinical Drug Investigation, 2021
Co-suspension Delivery™ Technology has been developed for the administration of albuterol sulfate pressurised inhalation suspension via metered-dose inhaler (AS MDI, PT007). We assessed the efficacy and safety of AS MDI versus Proventil® in order to determine the optimal dose of AS MDI to take to Phase III clinical trials.ASPEN (NCT03371459) and ANTORA
Christy Cappelletti, Andrea Maes, Kimberly Rossman, Michael Gillen, Craig LaForce, Edward M. Kerwin, Colin Reisner   +6 more
openaire   +2 more sources

Correction to: Drug Delivery from an Innovative LAMA/LABA Co-suspension Delivery Technology Fixed-Dose Combination MDI: Evidence of Consistency, Robustness, and Reliability [PDF]

AAPS PharmSciTech, 2017
This article was originally published Online First without open access. After publication it was discovered that the author had ordered open access during the production process. The incorrect license was assigned to this paper due to a technical error.
Amber, Doty, Jon, Schroeder, Kou, Vang, Mark, Sommerville, Mervin, Taylor, Brad, Flynn, David, Lechuga-Ballesteros, Peter, Mack   +7 more
openaire   +2 more sources

Mimicking chronic glaucoma over 6 months with a single intracameral injection of dexamethasone/fibronectin-loaded PLGA microspheres

Drug Delivery, 2022
To create a chronic glaucoma animal model by a single intracameral injection of biodegradable poly lactic-co-glycolic acid (PLGA) microspheres (Ms) co-loaded with dexamethasone and fibronectin (MsDexaFibro). MsDexaFibro were prepared by a water-in-oil-in-
Alba Aragón-Navas, María J. Rodrigo, David Garcia-Herranz, Teresa Martinez, Manuel Subias, Silvia Mendez, Jesús Ruberte, Judit Pampalona, Irene Bravo-Osuna, Julian Garcia-Feijoo, Luis E. Pablo, Elena Garcia-Martin, Rocío Herrero-Vanrell   +12 more
doaj   +1 more source