Results 31 to 40 of about 14,190,138 (234)

Efficacy, safety, and dose response of glycopyrronium administered by metered dose inhaler using co-suspension delivery technology in subjects with intermittent or mild-to-moderate persistent asthma: A randomized controlled trial [PDF]

Respiratory Medicine, 2018
This randomized, double-blind, placebo-controlled, cross-over, Phase II dose-ranging study investigated the efficacy and safety of GP MDI (glycopyrronium administered by metered dose inhaler formulated using co-suspension delivery technology) compared with an open-label active comparator, salmeterol dry powder inhaler (SAL DPI), in subjects with ...
Edward, Kerwin, Andrew, Wachtel, Lawrence, Sher, Jack, Nyberg, Patrick, Darken, Shahid, Siddiqui, Elizabeth A, Duncan, Colin, Reisner, Paul, Dorinsky   +8 more
openaire   +2 more sources

Adaptation to suspension growth: analysing the surface of suspension growth adapted Chinese hamster ovary cells [PDF]

, 2013
Many bio-pharmaceutical production processes are based upon the use of mammalian cell lines, such as Chinese hamster ovary (CHO) cells, capable of proliferation as single cells in suspension in a synthetic environment.
Walther, Christa G
core   +5 more sources

Insights into the innovative approaches in fiber technology for drug delivery and pharmaceuticals

, 2023
In the past few years there have been tremendous breakthroughs in the pharmaceutical and drug delivery fields with the emergence of novel technologies aiming to improve therapeutic outcomes and patient compliance Fiber based drug delivery systems have ...
Gehan M. Elossaily, Rashmi Arora, Pranay Wal, Saxena, B, Wal, P, Sachdeva, M, Shiva Mishra, Elossaily, GM, Md. Khalid Anwer, Ankita Wal, Tapan Behl, Charan Singh, Monika Sachdeva, Anwer, K, Bhagawati Saxena, Monica Gulati, Wal, A, Singh, C, Mishra, S, Behl, T, Arora, R, Gulati, M   +21 more
core   +1 more source

Glycopyrrolate/Formoterol Fumarate Metered Dose Inhaler Improves Lung Function versus Monotherapies in GOLD Category A Patients with COPD: Pooled Data from the Phase III PINNACLE Studies

International Journal of COPD, 2020
Fernando J Martinez,1 Klaus F Rabe,2 Brian J Lipworth,3 Samir Arora,4 Martin Jenkins,5 Ubaldo J Martin,6 Colin Reisner6,7 1Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA; 2Department of Pneumonology ...
Martinez FJ, Rabe KF, Lipworth BJ, Arora S, Jenkins M, Martin UJ, Reisner C   +6 more
doaj  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbubbling and microencapsulation by co-axial electrohydrodynamic atomization [PDF]

, 2009
Microbubbles coated with polymers or surfactants have been used in medical imaging for several years as ultrasound contrast agent particles and are now being investigated by researchers as drug and gene delivery vehicles and blood substitutes. Current
Farook, U.
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Bone and ocular safety of budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler in COPD: a 52-week randomized study

Respiratory Research, 2019
Background Long-term use of inhaled corticosteroids (ICSs) has been associated with increased risk of bone and ocular comorbidities. We evaluated the effects of the triple fixed-dose combination budesonide/glycopyrrolate/formoterol fumarate metered dose ...
Edward M. Kerwin, Gary T. Ferguson, Mindy Mo, Kiernan DeAngelis, Paul Dorinsky   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Dual Drug Loaded Lipid Nanocarrier Formulations for Topical Ocular Applications

International Journal of Nanomedicine, 2022
Ahmed Adel Ali Youssef,1,2 Narendar Dudhipala,2 Soumyajit Majumdar2,3 1Department of Pharmaceutical Technology, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt; 2Department of Pharmaceutics and Drug Delivery, School of Pharmacy ...
Youssef AAA, Dudhipala N, Majumdar S
doaj