Results 21 to 30 of about 69,822 (254)

P293 Drug delivery performance of budesonide (BD), glycopyrronium (GP) and formoterol (FF) triple combination (BGF) co-suspension™ delivery technology mdis [PDF]

Thorax, 2016
Introduction To assure consistency of clinical outcomes, orally inhaled products must have consistent in vitro delivered dose and aerosol properties. Achieving this consistency has been challenging with MDIs, particularly those that combine multiple drugs.
V Joshi, P Mack, J Archbell, G Li, M Arent, K Vang, S Ivatury, R Schultz, D Lechuga-Ballesteros, S Dwivedi, M Riebe   +10 more
openaire   +1 more source

Co-delivery of an HIV prophylactic and contraceptive using PGSU as a long-acting multipurpose prevention technology

, 2023
Poly(glycerol sebacate) urethane (PGSU) elastomers formulated with 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA), levonorgestrel (LNG), or a combination thereof can function as multipurpose prevention technology implants for prophylaxis against HIV and ...
Jarrod Cohen (8072684), Dennis Shull (14461801), Stephanie Reed (14461804)   +2 more
core   +1 more source

Pulmonary deposition of budesonide/glycopyrronium/formoterol fumarate dihydrate metered dose inhaler formulated using co-suspension delivery technology in healthy male subjects

European Journal of Pharmaceutical Sciences, 2020
This gamma scintigraphy imaging study assessed pulmonary, extrathoracic and regional lung deposition patterns of a radiolabelled inhaled corticosteroid/long-acting muscarinic antagonist/long-acting β2-agonist triple fixed-dose combination budesonide/glycopyrronium/formoterol fumarate dihydrate (BGF 320/14.4/10 μg), delivered by pressurised metered dose
Israel, S, Kumar, A, DeAngelis, K, Aurivillius, M, Dorinsky, P, Roche, N, Usmani, OS   +6 more
openaire   +3 more sources

Efficacy and safety of two doses of budesonide/formoterol fumarate metered dose inhaler in COPD

ERJ Open Research, 2020
Inhaled corticosteroid/long-acting β2-agonist combination therapy is a recommended treatment option for patients with chronic obstructive pulmonary disease (COPD) and increased exacerbation risk, particularly those with elevated blood eosinophil levels ...
Nicola A. Hanania, Alberto Papi, Antonio Anzueto, Fernando J. Martinez, Kimberly A. Rossman, Christy S. Cappelletti, Elizabeth A. Duncan, Jack S. Nyberg, Paul M. Dorinsky   +8 more
doaj   +1 more source

Application of multiple response optimization design to quantum dot-encoded microsphere bioconjugates hybridization assay [PDF]

, 2011
The optimization of DNA hybridization for genotyping assays is a complex experimental problem that depends on multiple factors such as assay formats, fluorescent probes, target sequence, experimental conditions, and data analysis.
Morgan, Sarah L., Sarah Thiollet, Bessant, Conrad M., Thiollet, Sarah, Conrad Bessant, Sarah L. Morgan   +5 more
core   +1 more source

A phase IIb randomized, chronic-dosing, incomplete block, cross-over study of glycopyrronium, delivered via metered dose inhaler, compared with a placebo and an active control in patients with moderate-to-severe COPD

Respiratory Research, 2018
Background Long-acting muscarinic antagonist (LAMA) and long-acting β2-agonist (LABA) bronchodilators are key to the pharmacologic treatment of chronic obstructive pulmonary disease (COPD).
Edward M. Kerwin, Selwyn Spangenthal, Christine Kollar, Earl St Rose, Colin Reisner   +4 more
doaj   +1 more source

Ultrasound assisted particle and cell manipulation on-chip [PDF]

, 2013
Ultrasonic fields are able to exert forces on cells and other micron-scale particles, including microbubbles. The technology is compatible with existing lab-on-chip techniques and is complementary to many alternative manipulation approaches due to its ...
Cochran, Sandy, Mulvana, Helen, Hill, Martyn   +2 more
core   +1 more source

Dose-response to inhaled glycopyrrolate delivered with a novel Co-Suspension™ Delivery Technology metered dose inhaler (MDI) in patients with moderate-to-severe COPD [PDF]

Respiratory Research, 2016
This study forms part of the first complete characterization of the dose-response curve for glycopyrrolate (GP) delivered using Co-Suspension™ Delivery Technology via a metered dose inhaler (MDI). We examined the lower GP MDI dose range to determine an optimal dose for patients with moderate-to-severe chronic obstructive pulmonary disease (COPD).This ...
FABBRI, Leonardo, Kerwin, Edward M, Spangenthal, Selwyn, Ferguson, Gary T, Rodriguez Roisin, Roberto, Pearle, James, Sethi, Sanjay, Orevillo, Chad, Darken, Patrick, St Rose, Earl, Fischer, Tracy, Golden, Michael, Dwivedi, Sarvajna, Reisner, Colin   +13 more
openaire   +3 more sources

Cardiovascular safety profile of a fixed-dose combination of glycopyrrolate and formoterol fumarate delivered via metered dose inhaler using co-suspension delivery technology

Pulmonary Pharmacology & Therapeutics, 2018
Glycopyrrolate/formoterol fumarate (GFF) metered dose inhaler (MDI) is a fixed-dose combination of the long-acting muscarinic antagonist (LAMA), glycopyrrolate (GP), and the long-acting β2-agonist (LABA), formoterol fumarate (FF), delivered via metered dose inhaler using innovative co-suspension delivery technology.
Gary T. Ferguson, Colin Reisner, James Pearle, Paolo DePetrillo, Andrea Maes, Ubaldo J. Martin   +5 more
openaire   +2 more sources

Efficacy, safety, and dose response of glycopyrronium administered by metered dose inhaler using co-suspension delivery technology in subjects with intermittent or mild-to-moderate persistent asthma: A randomized controlled trial [PDF]

Respiratory Medicine, 2018
This randomized, double-blind, placebo-controlled, cross-over, Phase II dose-ranging study investigated the efficacy and safety of GP MDI (glycopyrronium administered by metered dose inhaler formulated using co-suspension delivery technology) compared with an open-label active comparator, salmeterol dry powder inhaler (SAL DPI), in subjects with ...
Edward, Kerwin, Andrew, Wachtel, Lawrence, Sher, Jack, Nyberg, Patrick, Darken, Shahid, Siddiqui, Elizabeth A, Duncan, Colin, Reisner, Paul, Dorinsky   +8 more
openaire   +2 more sources