Results 21 to 30 of about 14,190,138 (234)

Mimicking chronic glaucoma over 6 months with a single intracameral injection of dexamethasone/fibronectin-loaded PLGA microspheres

Drug Delivery, 2022
To create a chronic glaucoma animal model by a single intracameral injection of biodegradable poly lactic-co-glycolic acid (PLGA) microspheres (Ms) co-loaded with dexamethasone and fibronectin (MsDexaFibro). MsDexaFibro were prepared by a water-in-oil-in-
Alba Aragón-Navas, María J. Rodrigo, David Garcia-Herranz, Teresa Martinez, Manuel Subias, Silvia Mendez, Jesús Ruberte, Judit Pampalona, Irene Bravo-Osuna, Julian Garcia-Feijoo, Luis E. Pablo, Elena Garcia-Martin, Rocío Herrero-Vanrell   +12 more
doaj   +1 more source

P293 Drug delivery performance of budesonide (BD), glycopyrronium (GP) and formoterol (FF) triple combination (BGF) co-suspension™ delivery technology mdis [PDF]

Thorax, 2016
Introduction To assure consistency of clinical outcomes, orally inhaled products must have consistent in vitro delivered dose and aerosol properties. Achieving this consistency has been challenging with MDIs, particularly those that combine multiple drugs.
V Joshi, P Mack, J Archbell, G Li, M Arent, K Vang, S Ivatury, R Schultz, D Lechuga-Ballesteros, S Dwivedi, M Riebe   +10 more
openaire   +1 more source

Pulmonary deposition of budesonide/glycopyrronium/formoterol fumarate dihydrate metered dose inhaler formulated using co-suspension delivery technology in healthy male subjects

European Journal of Pharmaceutical Sciences, 2020
This gamma scintigraphy imaging study assessed pulmonary, extrathoracic and regional lung deposition patterns of a radiolabelled inhaled corticosteroid/long-acting muscarinic antagonist/long-acting β2-agonist triple fixed-dose combination budesonide/glycopyrronium/formoterol fumarate dihydrate (BGF 320/14.4/10 μg), delivered by pressurised metered dose
Israel, S, Kumar, A, DeAngelis, K, Aurivillius, M, Dorinsky, P, Roche, N, Usmani, OS   +6 more
openaire   +3 more sources

Consistent Pulmonary Drug Delivery with Whole Lung Deposition Using the Aerosphere Inhaler: A Review of the Evidence

International Journal of COPD, 2021
Omar S Usmani,1 Nicolas Roche,2 Martin Jenkins,3 Neda Stjepanovic,4 Peter Mack,5 Wilfried De Backer6 1National Heart and Lung Institute (NHLI), Imperial College London, and Royal Brompton Hospital, London, UK; 2Respiratory Medicine, Cochin Hospital ...
Usmani OS, Roche N, Jenkins M, Stjepanovic N, Mack P, De Backer W   +5 more
doaj  

Heavy vehicle pitch dynamics and suspension tuning [PDF]

, 2008
The influence of suspension tuning of passenger cars on bounce and pitch ride performance has been explored in a number of studies, while only minimal efforts have been made for establishing similar rules for heavy vehicles.
Cao, Dongpu, Su, Chun-Yi, Rakheja, Subhash   +2 more
core   +4 more sources

Efficacy and safety of two doses of budesonide/formoterol fumarate metered dose inhaler in COPD

ERJ Open Research, 2020
Inhaled corticosteroid/long-acting β2-agonist combination therapy is a recommended treatment option for patients with chronic obstructive pulmonary disease (COPD) and increased exacerbation risk, particularly those with elevated blood eosinophil levels ...
Nicola A. Hanania, Alberto Papi, Antonio Anzueto, Fernando J. Martinez, Kimberly A. Rossman, Christy S. Cappelletti, Elizabeth A. Duncan, Jack S. Nyberg, Paul M. Dorinsky   +8 more
doaj   +1 more source

Perceptions of co-design, co-development and co-delivery (Co-3D) as part of the co-production process – Insights for climate services [PDF]

, 2023
Co-design, co-development, and co-delivery (Co-3D for short) are activities within the co-production research pathway that are increasingly being used in climate change science and adaptation projects.
J. Melbourne-Thomas, Hopkins, M., L.X.C. Dutra, B.B. Lin, S. Merson, Swirepik, A., Fleming, A., Merson, S., E. Bohensky, A. Swirepik, T. Moore, Bohensky, E., Dutra, L.X.C., A. Fleming, Moore, T., Stone-Jovicich, S., Clarke, J.M., Vertigan, C., C. Vertigan, M. Hopkins, Tozer, C., Donegan, L., C. Tozer, Melbourne-Thomas, J., Lin, B.B., S. Stone-Jovicich, Remenyi, T., J.M. Clarke, L. Donegan, T. Remenyi   +29 more
core   +1 more source

A phase IIb randomized, chronic-dosing, incomplete block, cross-over study of glycopyrronium, delivered via metered dose inhaler, compared with a placebo and an active control in patients with moderate-to-severe COPD

Respiratory Research, 2018
Background Long-acting muscarinic antagonist (LAMA) and long-acting β2-agonist (LABA) bronchodilators are key to the pharmacologic treatment of chronic obstructive pulmonary disease (COPD).
Edward M. Kerwin, Selwyn Spangenthal, Christine Kollar, Earl St Rose, Colin Reisner   +4 more
doaj   +1 more source

Dose-response to inhaled glycopyrrolate delivered with a novel Co-Suspension™ Delivery Technology metered dose inhaler (MDI) in patients with moderate-to-severe COPD [PDF]

Respiratory Research, 2016
This study forms part of the first complete characterization of the dose-response curve for glycopyrrolate (GP) delivered using Co-Suspension™ Delivery Technology via a metered dose inhaler (MDI). We examined the lower GP MDI dose range to determine an optimal dose for patients with moderate-to-severe chronic obstructive pulmonary disease (COPD).This ...
FABBRI, Leonardo, Kerwin, Edward M, Spangenthal, Selwyn, Ferguson, Gary T, Rodriguez Roisin, Roberto, Pearle, James, Sethi, Sanjay, Orevillo, Chad, Darken, Patrick, St Rose, Earl, Fischer, Tracy, Golden, Michael, Dwivedi, Sarvajna, Reisner, Colin   +13 more
openaire   +3 more sources

Cardiovascular safety profile of a fixed-dose combination of glycopyrrolate and formoterol fumarate delivered via metered dose inhaler using co-suspension delivery technology

Pulmonary Pharmacology & Therapeutics, 2018
Glycopyrrolate/formoterol fumarate (GFF) metered dose inhaler (MDI) is a fixed-dose combination of the long-acting muscarinic antagonist (LAMA), glycopyrrolate (GP), and the long-acting β2-agonist (LABA), formoterol fumarate (FF), delivered via metered dose inhaler using innovative co-suspension delivery technology.
Gary T. Ferguson, Colin Reisner, James Pearle, Paolo DePetrillo, Andrea Maes, Ubaldo J. Martin   +5 more
openaire   +2 more sources