Pharmaceutical Cocrystals: Regulatory and Strategic Aspects, Design and Development [PDF]
Advanced Pharmaceutical Bulletin, 2016 Cocrystal is a concept of the supramolecular chemistry which is gaining the extensive interest of researchers from pharmaceutical and chemical sciences and of drug regulatory agencies.
Dipak Dilip Gadade +1 more
doaj +1 more source
Vibrational spectra of C60C8H8 and C70C8H8 in the rotor-stator and polymer phases [PDF]
, 2007 C60-C8H8 and C70-C8H8 are prototypes of rotor-stator cocrystals. We present infrared and Raman spectra of these materials and show how the rotor-stator nature is reflected in their vibrational properties.
Abe H. +28 more
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Celecoxib cocrystal polymorphs† [PDF]
Acta Crystallographica Section A Foundations and Advances, 2014 Celecoxib (CEL) is a well-known nonsteroidal anti-inflammatory drug (NSAID) and selectively used from the cocxib family. It is a specific COX-2 inhibitor for pain and inflammation without inhibiting COX-1. A major downside of this popular NSAID is its poor aqueous solubility (9 mg L–1), which limits bioavailability (40%). Several methods were attempted
Geetha Bolla +2 more
openaire +1 more source
Pharmaceutical Cocrystals: New Solid Phase Modification Approaches for the Formulation of APIs
Pharmaceutics, 2018 Cocrystals can be used as an alternative approach based on crystal engineering to enhance specific physicochemical and biopharmaceutical properties of active pharmaceutical ingredients (APIs) when the approaches to salt or polymorph formation do not meet
Anna Karagianni +2 more
doaj +1 more source
Introductory lecture: Mechanochemistry, a versatile synthesis strategy for new materials. [PDF]
, 2014 Mechanochemistry deals with reactions induced by the input of mechanical energy - for example by impacts within a vibratory ball mill. The technique has a long history with significant contributions from Ostwald, Carey Lea and, notably, Faraday ...
Eddleston, Mark D, Jones, William
core +1 more source
Hydrogen-bonding synthons in lamotrigine salts: 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazin-2-ium 2-[(2-carboxyphenyl)disulfanyl]benzoate in its monohydrate and anhydrous forms [PDF]
, 2016 Lamotrigine is a drug used in the treatment of epilepsy and related convulsive diseases. The drug in its free form is rather inadequate for pharmacological use due to poor absorption by the patient, which limits its bioavailability.
Baggio, Ricardo Fortunato +2 more
core +1 more source
Co-crystal structures of furosemide:urea and carbamazepine:indomethacin determined from powder x-ray diffraction data [PDF]
, 2020 Co-crystallization is a promising approach to improving both the solubility and the dissolution rate of active pharmaceutical ingredients. Crystal structure determination from powder diffraction data plays an important role in determining co-crystal ...
Al Rahal, Okba +4 more
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Novel Cocrystals of Vonoprazan: Machine Learning-Assisted Discovery
Pharmaceutics, 2022 Vonoprazan (VPZ) is the first-in-class potassium-competitive acid blocker (P-CAB), and has many advantages over proton pump inhibitors (PPIs). It is administered as a fumarate salt for the treatment of acid-related diseases, including reflux esophagitis,
Min-Jeong Lee +6 more
doaj +1 more source
Coordination networks incorporating halogen-bond donor sites and azobenzene groups [PDF]
, 2016 Two Zn coordination networks, [Zn(1)(Py)2]2(2-propanol)n (3) and [Zn(1)2(Bipy)2](DMF)2n (4), incorporating halogen-bond (XB) donor sites and azobenzene groups have been synthesized and fully characterized.
Fernandez-Palacio F. +6 more
core +1 more source
Solubility enhancement of carvedilol using drug–drug cocrystallization with hydrochlorothiazide
Future Journal of Pharmaceutical Sciences, 2020 Background Increasing hydrophilicity of poorly water-soluble drugs is a major challenge in drug discovery and development. Cocrystallization is one of the techniques to enhance the hydrophilicity of such drugs.
Shivarani Eesam +4 more
doaj +1 more source