Results 51 to 60 of about 16,055 (257)
Pharmaceuticals, 2023 In this present research, an attempt has been made to address the influence of drug-coformer stoichiometric ratio on cocrystal design and its impact on improvement of solubility and dissolution, as well as bioavailability of poorly soluble telmisartan ...
Manami Dhibar +7 more
doaj +1 more source
A 2:1 cocrystal of 6,13-dihydropentacene and pentacene [PDF]
, 2002 6,13-Dihydropentacene and pentacene cocrystallize in a ratio of 2:1, i.e. C22H16·0.5C22H14, during vapour transport of commercial pentacene in a gas flow.
Baas, Jacob, +6 more
core +5 more sources
Modularity and three-dimensional isostructurality of novel synthons in sulfonamide–lactam cocrystals
IUCrJ, 2015 The design of novel supramolecular synthons for functional groups relevant to drugs is an essential prerequisite for applying crystal engineering in the development of novel pharmaceutical cocrystals.
Geetha Bolla +2 more
doaj +1 more source
Trapping virtual pores by crystal retro-engineering [PDF]
, 2015 Stable guest-free porous molecular crystals are uncommon. By contrast, organic molecular crystals with guest-occupied cavities are frequently observed, but these cavities tend to be unstable and collapse on removal of the guests—this feature has been ...
AI Day +54 more
core +1 more source
Mechanochemical Synthesis of Pharmaceutical Cocrystal Suspensions via Hot Melt Extrusion: Feasibility Studies and Physicochemical Characterisation [PDF]
, 2016 Engineered cocrystals offer an alternative solid drug form with tailored physicochemical properties. Interestingly, although cocrystals provide many new possibilities, they also present new challenges, particularly in regard to their design and large ...
Andrews, Gavin P. +5 more
core +1 more source
ADMET and DMPK, 2019 Since there are conflicting reports in the literature on solubility and dissolution advantages of cocrystals over free forms, we systematically studied solubility and intrinsic dissolution rates of a weakly basic drug, ketoconazole, and its cocrystals ...
Jaydip M. Vasoya +2 more
doaj +1 more source
Organic Photothermal Cocrystals: Rational Design, Controlled Synthesis, and Advanced Application
Advanced Science, 2023 Organic photothermal cocrystals, integrating the advantages of intrinsic organic cocrystals and the fascinating photothermal conversion ability, hold attracted considerable interest in both basic science and practical applications, involving ...
Ye‐Tao Chen +5 more
doaj +1 more source
Antibiotics, 2021 Cocrystallization is a promising approach to alter physicochemical properties of active pharmaceutical ingredients (hereafter abbreviated as APIs) bearing poor profile.
Noor Ul Islam +6 more
doaj +1 more source
Insight into flufenamic acid cocrystal dissolution in the presence of a polymer in solution: from single crystal to powder dissolution [PDF]
, 2017 Effects of three polymers, polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), and copolymer of vinylpyrrolidone/vinyl acetate (PVP-VA), on the dissolution behavior of the cocrystals of flufenamic acid with theophylline (FFA-TP CO) and nicotinamide ...
Fábián, László +5 more
core +2 more sources
Air-Stable Cyclohexasulfur as Cocrystal [PDF]
Crystal Growth & Design, 2012 A new stable cyclohexasulfur (cyclo-S6) was discovered in the crystal of 3,5-diphenyl-1,2,4-dithiazol-1-ium (dpdti); dpdti was synthesized via an oxidation reaction of thiobenzamide with iodine in ...
Kunihisa Sugimoto +3 more
openaire +1 more source