Mechanochemical Synthesis of Pharmaceutical Cocrystal Suspensions via Hot Melt Extrusion: Feasibility Studies and Physicochemical Characterisation [PDF]
, 2016 Engineered cocrystals offer an alternative solid drug form with tailored physicochemical properties. Interestingly, although cocrystals provide many new possibilities, they also present new challenges, particularly in regard to their design and large ...
Andrews, Gavin P. +5 more
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Modularity and three-dimensional isostructurality of novel synthons in sulfonamide–lactam cocrystals
IUCrJ, 2015 The design of novel supramolecular synthons for functional groups relevant to drugs is an essential prerequisite for applying crystal engineering in the development of novel pharmaceutical cocrystals.
Geetha Bolla +2 more
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Introductory lecture: Mechanochemistry, a versatile synthesis strategy for new materials. [PDF]
, 2014 Mechanochemistry deals with reactions induced by the input of mechanical energy - for example by impacts within a vibratory ball mill. The technique has a long history with significant contributions from Ostwald, Carey Lea and, notably, Faraday ...
Eddleston, Mark D, Jones, William
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Organic Photothermal Cocrystals: Rational Design, Controlled Synthesis, and Advanced Application
Advanced Science, 2023 Organic photothermal cocrystals, integrating the advantages of intrinsic organic cocrystals and the fascinating photothermal conversion ability, hold attracted considerable interest in both basic science and practical applications, involving ...
Ye‐Tao Chen +5 more
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Pharmaceuticals, 2023 In this present research, an attempt has been made to address the influence of drug-coformer stoichiometric ratio on cocrystal design and its impact on improvement of solubility and dissolution, as well as bioavailability of poorly soluble telmisartan ...
Manami Dhibar +7 more
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Insight into flufenamic acid cocrystal dissolution in the presence of a polymer in solution: from single crystal to powder dissolution [PDF]
, 2017 Effects of three polymers, polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), and copolymer of vinylpyrrolidone/vinyl acetate (PVP-VA), on the dissolution behavior of the cocrystals of flufenamic acid with theophylline (FFA-TP CO) and nicotinamide ...
Fábián, László +5 more
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ADMET and DMPK, 2019 Since there are conflicting reports in the literature on solubility and dissolution advantages of cocrystals over free forms, we systematically studied solubility and intrinsic dissolution rates of a weakly basic drug, ketoconazole, and its cocrystals ...
Jaydip M. Vasoya +2 more
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Air-Stable Cyclohexasulfur as Cocrystal [PDF]
Crystal Growth & Design, 2012 A new stable cyclohexasulfur (cyclo-S6) was discovered in the crystal of 3,5-diphenyl-1,2,4-dithiazol-1-ium (dpdti); dpdti was synthesized via an oxidation reaction of thiobenzamide with iodine in ...
Kunihisa Sugimoto +3 more
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Solubility enhancement of carvedilol using drug–drug cocrystallization with hydrochlorothiazide
Future Journal of Pharmaceutical Sciences, 2020 Background Increasing hydrophilicity of poorly water-soluble drugs is a major challenge in drug discovery and development. Cocrystallization is one of the techniques to enhance the hydrophilicity of such drugs.
Shivarani Eesam +4 more
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Trapping virtual pores by crystal retro-engineering [PDF]
, 2015 Stable guest-free porous molecular crystals are uncommon. By contrast, organic molecular crystals with guest-occupied cavities are frequently observed, but these cavities tend to be unstable and collapse on removal of the guests—this feature has been ...
AI Day +54 more
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