Results 11 to 20 of about 21,454 (169)

Apoptotic inducement of neuronal cells by codeine: possible role of disrupted redox state and caspase 3 signaling

Heliyon, 2021
Background: Codeine, a common drug of abuse, has been reported to induce organ damage; however, there are scanty available data on the effects of codeine on the brain. Objective: Thus, we tested the hypothesis that redox dysregulation and inflammation of
A.F. Ajayi, R.E. Akhigbe
doaj   +1 more source

The importance of 6-MAM levels and morphine/codeine ratio in diagnosis of death among drug addicts [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2019
Introduction/Objective. Heroin is metabolized to 6-monoacetylmorphine (6-MAM) and morphine. The objective of this study is to examine 6-MAM, morphine, and codeine relationships in order to distinguish deaths related to heroin consumption from deaths ...
Jakšić Vladimir, Mirić Dijana, Ilić Aleksandra, Matejić Suzana, Stević Snežana, Vitošević Zdravko   +5 more
doaj   +1 more source

A clinical tool for reducing central nervous system depression among neonates exposed to codeine through breast milk. [PDF]

PLoS ONE, 2013
Neonates are commonly exposed to maternal codeine through breast milk. Central Nervous System (CNS) depression has been reported in up to 24% of nurslings following codeine exposure.
Lauren E Kelly, Shahnaz A Chaudhry, Michael J Rieder, Geert 't Jong, Myla E Moretti, Andrea Lausman, Colin Ross, Howard Berger, Bruce Carleton, Michael R Hayden, Parvaz Madadi, Gideon Koren   +11 more
doaj   +1 more source

Clinical Characteristics of Over-The-Counter Drug Misusers in Psychiatric Practice in Japan: Comparison Between Codeine Misusers and Dextromethorphan Misusers. [PDF]

Neuropsychopharmacol Rep
In Japan, DXM abuse among young women has become a significant public health issue. ABSTRACT Purpose In recent years, the misuse of over‐the‐counter (OTC) medications has been increasing in psychiatric clinical settings in Japan. This study aimed to compare individuals who misuse codeine (COD) with those who misuse dextromethorphan (DXM) to clarify the
Tanibuchi Y, Omiya S, Usami T, Shimane T, Matsumoto T.   +4 more
europepmc   +2 more sources

Opium trade and use during the Late Bronze Age: Organic residue analysis of ceramic vessels from the burials of Tel Yehud, Israel

Archaeometry, EarlyView., 2022
Abstract Organic residue analysis was conducted on various vessels from burials at Tel Yehud, Israel. The analyses led to new reliable evidence for the presence of opioid alkaloids and their decomposition products. This research revitalizes a decades‐old discussion on the presence and function of the opium trade across a cultural region of utmost ...
Vanessa Linares, Eriola Jakoel, Ron Be’eri, Oded Lipschits, Ronny Neumann, Yuval Gadot   +5 more
wiley   +1 more source

Spatial clustering of codeine use and its association with depression: a geospatial analysis of nationally representative South African data

Journal of Affective Disorders Reports, 2022
Background: There is an alarming trend in sub-Saharan Africa in the use of codeine-containing pharmaceuticals, but its risk of common comorbidities, such as mental health, remains unquantified at a national-level. We investigated the relationship between
Princess Nyoni, Diego F. Cuadros, Andrew Gibbs, Frank Tanser, Rob Slotow, Jonathan K Burns, Andrew Tomita   +6 more
doaj   +1 more source

A Single Site Population Study to Investigate CYP2D6 Phenotype of Patients with Persistent Non-Malignant Pain

Medicina, 2019
Background and Objectives: Codeine requires biotransformation by the CYP2D6 enzyme, encoded by the polymorphic CYP2D6 gene, to morphine for therapeutic efficacy. CYP2D6 phenotypes of poor, intermediate, and ultra-rapid metabolisers are at risk of codeine
Helen Radford, Karen H. Simpson, Suzanne Rogerson, Mark I. Johnson   +3 more
doaj   +1 more source

Testicular toxicity following chronic codeine administration is via oxidative DNA damage and up-regulation of NO/TNF-α and caspase 3 activities.

PLoS ONE, 2020
BackgroundCodeine, a 3-methylmorphine, and other related opioids have been implicated in androgen suppression, although the associated mechanisms remain unclear.AimTherefore, the objective of the current study was to elucidate the in vivo molecular ...
Roland Akhigbe, Ayodeji Ajayi
doaj   +1 more source

Resolving Issues About Efficacy and Safety of Low-Dose Codeine in Combination Analgesic Drugs: A Systematic Review

Pain and Therapy, 2020
Introduction The objective of this systematic review is to reflect on assumptions in relation to codeine use in combination with other analgesics. Methods MEDLINE was searched according to the predetermined keywords and criteria.
Ivan Ćelić, Lidija Bach-Rojecky, Iveta Merćep, Ana Soldo, Anja Kos Petrak, Ana Bučan   +5 more
doaj   +1 more source

Effect of codeine on CYP450 isoform activity of rats

Pharmaceutical Biology, 2017
Context: Codeine, also known as 3-methylmorphine, is an opiate used to treat pain, as a cough medicine and for diarrhoea. No study on the effects of codeine on the metabolic capacity of CYP enzyme is reported.
Shuanghu Wang, Yanwen Dong, Ke Su, Jing Zhang, Linyi Wang, Anyue Han, Congcong Wen, Xianqin Wang, Yan He   +8 more
doaj   +1 more source