Results 1 to 10 of about 372,161 (260)

Synonymous codon usage defines functional gene families [PDF]

BMC Biology
Background The degeneracy of the genetic code is increasingly recognized for roles in regulating translation rate, protein folding, and cell response. However, the functional genomics of codon usage patterns remains poorly defined.
Farzan Ghanegolmohammadi, Shinsuke Ohnuki, Shane Byrne, Rahul Raman, Thomas J. Begley, Peter C. Dedon   +5 more
doaj   +2 more sources

Optimization of Col H Gene Encoding Clostridium histolyticum Collagenase to Express in Escherichia coli [PDF]

Journal of Health Sciences and Surveillance System, 2022
Background: A given amino acid sequence can be encoded by a huge number of different nucleic acid sequences. These sequences, however, have proved not to be equally useful.
Seyed Mohammad Amin Mahdian, Abbasali Raz, Navid Dinparast Djadid, Hamzeh Alipour   +3 more
doaj   +1 more source

Overview of tRNA Modifications in Chloroplasts

Microorganisms, 2022
The chloroplast is a promising platform for biotechnological innovation due to its compact translation machinery. Nucleotide modifications within a minimal set of tRNAs modulate codon–anticodon interactions that are crucial for translation efficiency ...
Maxime Fages-Lartaud, Martin Frank Hohmann-Marriott   +1 more
doaj   +1 more source

Tissue Specific Expression Levels of Apoptosis Involved Genes Have Correlations with Codon and Amino Acid Usage [PDF]

Genomics & Informatics, 2016
Different mechanisms, including transcriptional and post transcriptional processes, regulate tissue specific expression of genes. In this study, we report differences in gene/protein compositional features between apoptosis involved genes selectively ...
Mohammadreza Hajjari, Iman Sadeghi, Abbas Salavaty, Habib Nasiri, Maryam Tahmasebi Birgani   +4 more
doaj   +1 more source

Data Driven Approach to Analyze Competency Teaching in an Undergraduate Biology Program: A Case Study

Journal of the Scholarship of Teaching and Learning, 2022
Recent calls to reform undergraduate biology education, including Vision and Change in Undergraduate Biology Education, have led biology departments to examine their curriculum to determine the extent to which it aligns with Vision and Change content ...
Deborah Donovan, Alexa Clemmons, Alison Crowe   +2 more
doaj   +1 more source

KRAS Mutation: Characterization and Its Impact on Survival Outcome of Patients with Metastatic Colorectal Cancer

Frontiers in Bioscience-Landmark, 2022
Introduction: Colorectal cancer (CRC) is one of the most common cancer types, with rising incidence due to imbalanced lifestyle and dietary habit. Association between CRC cases and KRAS mutation has been established recently.
Datul Damit, Ravi Patnaik, Li Ling Chaw, Shir Kiong Lu, Pemasiri Upali Telisinghe, Zen Huat Lu, Kenneth Kok, Long Chiau Ming, Ya Chee Lim   +8 more
doaj   +1 more source

Basic principles of the genetic code extension [PDF]

Royal Society Open Science, 2020
Compounds including non-canonical amino acids (ncAAs) or other artificially designed molecules can find a lot of applications in medicine, industry and biotechnology.
Paweł Błażej, Małgorzata Wnetrzak, Dorota Mackiewicz, Paweł Mackiewicz   +3 more
doaj   +1 more source

Genomic insight into pathogenicity of dematiaceous fungus Corynespora cassiicola [PDF]

PeerJ, 2017
Corynespora cassiicola is a common plant pathogen that causes leaf spot disease in a broad range of crop, and it heavily affect rubber trees in Malaysia (Hsueh, 2011; Nghia et al., 2008).
Hong Keat Looi, Yue Fen Toh, Su Mei Yew, Shiang Ling Na, Yung-Chie Tan, Pei-Sin Chong, Jia-Shiun Khoo, Wai-Yan Yee, Kee Peng Ng, Chee Sian Kuan   +9 more
doaj   +2 more sources

The constraints between amino acids influence the unequal distribution of codons and protein sequence evolution

Royal Society Open Science, 2021
Four nucleotides (A, U, C and G) constitute 64 codons at free combination but 64 codons are unequally assigned to 21 items (20 amino acids plus one stop). About 500 amino acids are known but only 20 are selected to make up the proteins.
Yi Qian, Rui Zhang, Xinglu Jiang, Guoqiu Wu   +3 more
doaj   +1 more source

Prevalent use and evolution of exonic regulatory sequences in the human genome

Natural Sciences, 2023
It has long been known that exons can serve as cis‐regulatory sequences, such as enhancers. However, the prevalence of such dual‐use of exons and how they evolve remain elusive.
Jing Chen, Pengyu Ni, Siwen Wu, Meng Niu, Jun‐tao Guo, Zhengsheng Su   +5 more
doaj   +1 more source