Results 11 to 20 of about 616,369 (340)

Prevalent use and evolution of exonic regulatory sequences in the human genome

Natural Sciences, 2023
It has long been known that exons can serve as cis‐regulatory sequences, such as enhancers. However, the prevalence of such dual‐use of exons and how they evolve remain elusive.
Jing Chen, Pengyu Ni, Siwen Wu, Meng Niu, Jun‐tao Guo, Zhengsheng Su   +5 more
doaj   +1 more source

Geographical distribution of Brucella melitensis inferred from rpoB gene variation

Journal of Infection in Developing Countries, 2017
Introduction: Currently available tests have limitations for the identification of Brucella species and strains, and their genetic lineage. The genome sequence of the rpoB gene encoding the β-subunit of DNA-dependent RNA polymerase was investigated for ...
Kim-Kee Tan, Yung-Chie Tan, Li-Yen Chang, Kok Wei Lee, Siti Sarah Nor'e, Wai-Yan Yee, Chee-Choong Hoh, Sazaly AbuBakar   +7 more
doaj   +1 more source

The Mechanisms of Codon Reassignments in Mitochondrial Genetic Codes [PDF]

, 2007
Many cases of non-standard genetic codes are known in mitochondrial genomes. We carry out analysis of phylogeny and codon usage of organisms for which the complete mitochondrial genome is available, and we determine the most likely mechanism for codon ...
A Reyes, A Schneider, AM Nedelcu, AM Simpson, AP Sibler, BF Lang, C Gissi, CA Lozupone, CE Bullerwell, D Urbina, DH Ardell, DV Lavrov, DW Schultz, DW Schultz, E Seif, E Talla, EM Denovan-Wright, FHC Crick, G Burger, G Burger, G Burger, H Asahara, HS Kim, J Castrasena, J Matsugi, J Swire, JD Alfonzo, JL Blanchard, JL Boore, K Hancock, K Tomita, Knight, Knight, M Ehara, M Ehara, M Kimura, M Nohara, M Turmel, MAS Santos, MAS Santos, ME Saks, MJ Laforest, MJ Telford, MV Sanchez Puerta, N Spruyt, NJ Savill, Paul G. Higgs, PG Higgs, PG Higgs, PJ Keeling, PS Lovett, R Giegé, R Koszul, RC Morris, S Kerscher, S Matsuyama, S Osawa, S Osawa, S Osawa, S Sengupta, S Yokobori, SE Massey, SG Andersson, SG Andersson, SJ Freeland, Supratim Sengupta, T Muramatsu, Tomita, Tomita, U Kück, Xiaoguang Yang, Y Hayashi-Ishimaru, Y Hayashi-Ishimaru, Y Inagaki, Y Kuchino   +74 more
core   +4 more sources

Translation elongation can control translation initiation on eukaryotic mRNAs [PDF]

, 2013
Synonymous codons encode the same amino acid, but differ in other biophysical properties. The evolutionary selection of codons whose properties are optimal for a cell generates the phenomenon of codon bias.
Aitken, Anand, Brachmann, Browne, Carlini, Chan, Charneski, Chu, Chu, Chu, Ciandrini, Dana, Firczuk, Fluitt, Gibson, Gould, Grant, Haar, Haar, Hense, Hershberg, Hu, Ikemura, Ingolia, Ingolia, Jeon, Kemp, Kotula, Kudla, Liti, Liu, Lombardi, McCarthy, Merritt, Mirzaei, Moriya, Mossadegh, Nagata, Neafsey, Outchkourov, Patel, Plant, Powell, Qian, Sala-Newby, Salas-Marco, Shalgi, Sikorski, Sinclair, Slimko, Stadler, Stark, Wolin, Yadava, Zhou, Zouridis   +55 more
core   +2 more sources

Candidate essential genes in Burkholderia cenocepacia J2315 identified by genome-wide TraDIS

Frontiers in Microbiology, 2016
Burkholderia cenocepacia infection often leads to fatal cepacia syndrome in cystic fibrosis patients. However, antibiotic therapy rarely results in complete eradication of the pathogen due to its intrinsic resistance to many clinically available ...
Yee-Chin Wong, Moataz Abd El Ghany, Raeec Naeem, Kok-Wei lee, Yung-Chie Tan, Arnab Pain, Sheila Nathan   +6 more
doaj   +1 more source

Codon Bias Patterns of $E.coli$'s Interacting Proteins [PDF]

, 2015
Synonymous codons, i.e., DNA nucleotide triplets coding for the same amino acid, are used differently across the variety of living organisms. The biological meaning of this phenomenon, known as codon usage bias, is still controversial.
Cimini, Giulio, Deiana, Antonio, Dilucca, Maddalena, Giansanti, Andrea, Semmoloni, Andrea   +4 more
core   +4 more sources

Intracellular management of information: from DNA to proteins

tripleC: Communication, Capitalism & Critique, 2009
The living features of cells constitute an information flow from a central database, the nuclear DNA, to molecular effectors, proteins, which are synthesised in the cytoplasm.
Juan M. Lara
doaj   +1 more source

Analysis of p53 codon 72 polymorphism and HPV 5,8 E6 oncoprotein expression in Basal cell carcinoma in Basrah [PDF]

The Medical Journal of Basrah University, 2016
Background: Two polymorphic forms of the p53 gene that codes either for Arginine or proline at codon 72 were identified, However, this individual might have one of the three genotypes: Arginine/Arginine, Proline/Proline or Arginine /Proline.
Wasan AA. Sayhood, Hassan J. Hasony, Khalil I. AL-Hamdi   +2 more
doaj   +1 more source

Translation initiation factor eIF3 promotes programmed stop codon readthrough. [PDF]

, 2015
Programmed stop codon readthrough is a post-transcription regulatory mechanism specifically increasing proteome diversity by creating a pool of C-terminally extended proteins.
Beznoskova, Petra, Jansen, Myrte E, Valasek, Leos S, von der Haar, Tobias, Wagner, Susan   +4 more
core   +1 more source

Expanding codon size

eLife, 2022
Engineering transfer RNAs to read codons consisting of four bases requires changes in tRNA that go beyond the anticodon sequence.
Tarana Siddika, Ilka U Heinemann, Patrick O’Donoghue   +2 more
openaire   +3 more sources