Estimating translational selection in Eukaryotic Genomes [PDF]
, 2009 Natural selection on codon usage is a pervasive force that acts on a large variety of prokaryotic and eukaryotic genomes. Despite this, obtaining reliable estimates of selection on codon usage has proved complicated, perhaps due to the fact that the ...
Adams +43 more
core +2 more sources
Exploring Differentially Expressed Genes and Immune Modulation in Diffuse Large B-Cell Lymphoma through RNA Sequencing Analysis [PDF]
Iranian Journal of Medical SciencesBackground: Diffuse large B-cell lymphoma (DLBCL) is globally recognized as the most prevalent and aggressive subtype of non-Hodgkin lymphoma. While conventional treatments are effective initially, the disease can become resistant or relapse over time ...
Nor Adzimah Johdi +4 more
doaj +1 more source
Frontiers in Genetics, 2020 Bacterial oxidative stress responses are generally controlled by transcription factors that modulate the synthesis of RNAs with the aid of some sRNAs that control the stability, and in some cases the translation, of specific mRNAs.
Lorenzo Eugenio Leiva +15 more
doaj +1 more source
Evolution: are the monkeys’ typewriters rigged? [PDF]
Royal Society Open Science, 2014 Evolution is presumed to proceed by random mutations, which increase an individual’s fitness. Increased fitness produces a higher survival rate for those individuals within populations and drives the variants to fixation over large timescales to produce ...
Michael R. Garvin, Anthony J. Gharrett
doaj +1 more source
Impact of the Specific Mutation in KRAS Codon 12 Mutated Tumors on Treatment Efficacy in Patients with Metastatic Colorectal Cancer Receiving Cetuximab-Based First-Line Therapy: A Pooled Analysis of Three Trials [PDF]
, 2012 Purpose: This study investigated the impact of specific mutations in codon 12 of the Kirsten-ras (KRAS) gene on treatment efficacy in patients with metastatic colorectal cancer (mCRC).
Allegra CJ +41 more
core +1 more source
A modular and optimized single marker system for generating Trypanosoma brucei cell lines expressing T7 RNA polymerase and the tetracycline repressor [PDF]
Open Biology, 2012 Here, we present a simple modular extendable vector system for introducing the T7 RNA polymerase and tetracycline repressor genes into Trypanosoma brucei.
S. K. Poon +4 more
doaj +1 more source
Genome landscapes and bacteriophage codon usage [PDF]
, 2007 Across all kingdoms of biological life, protein-coding genes exhibit unequal usage of synonmous codons. Although alternative theories abound, translational selection has been accepted as an important mechanism that shapes the patterns of codon usage in ...
A Eyre-Walker +60 more
core +6 more sources
A model for codon position bias in RNA editing [PDF]
, 2005 RNA editing can be crucial for the expression of genetic information via inserting, deleting, or substituting a few nucleotides at specific positions in an RNA sequence. Within coding regions in an RNA sequence, editing usually occurs with a certain bias
Bundschuh, Ralf, Liu, Tsunglin
core +2 more sources
Atomic mutagenesis of stop codon nucleotides reveals the chemical prerequisites for release factor-mediated peptide release. [PDF]
, 2018 Termination of protein synthesis is triggered by the recognition of a stop codon at the ribosomal A site and is mediated by class I release factors (RFs).
Clementi, Nina +11 more
core +3 more sources
Developing and evaluating a pollination systems knowledge assessment in a multidisciplinary course
International Journal of STEM Education, 2022 Background Although pollinators play an integral role in human well-being, their continued global decline reflects the need to provide and evaluate general pollinator knowledge to promote their conservation.
P. Citlally Jimenez +3 more
doaj +1 more source