Results 41 to 50 of about 9,001 (100)
Microbial Cell Factories, 2021 Background Codon optimization is a common method to improve protein expression levels in Pichia pastoris and the current strategy is to replace rare codons with preferred codons to match the codon usage bias.
Yide Huang +6 more
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Codon Bias Signatures, Organization of Microorganisms in Codon Space, and Lifestyle [PDF]
Molecular Biology and Evolution, 2004 New and simple numerical criteria based on a codon adaptation index are applied to the complete genomic sequences of 80 Eubacteria and 16 Archaea, to infer weak and strong genome tendencies toward content bias, translational bias, and strand bias. These criteria can be applied to all microbial genomes, even those for which little biological information
Carbone, Alessandra +2 more
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Big data in breast cancer: Towards precision treatment
Digital HealthBreast cancer is the most prevalent and deadliest cancer among women globally, representing a major threat to public health. In response, the World Health Organization has established the Global Breast Cancer Initiative framework to reduce breast cancer ...
Hao Zhang +5 more
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Genome Medicine, 2021 Background Gene expression is highly variable across tissues of multi-cellular organisms, influencing the codon usage of the tissue-specific transcriptome.
Douglas Meyer +10 more
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Distinct responses to rare codons in select Drosophila tissues
eLife, 2022 Codon usage bias has long been appreciated to influence protein production. Yet, relatively few studies have analyzed the impacts of codon usage on tissue-specific mRNA and protein expression.
Scott R Allen +8 more
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Data, 2020 The Malaysian stingless bee industry is hugely dependent on wild colonies. Nevertheless, the availability of new queens to establish new colonies is insufficient to meet the growing demand for hives in the industry.
Chien-Yeong Wee +5 more
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Enterovirus A Shows Unique Patterns of Codon Usage Bias in Conventional Versus Unconventional Clade
Frontiers in Cellular and Infection Microbiology, 2022 Enterovirus A (EV-A) species cause hand, foot and mouth disease (HFMD), threatening the health of young children. Understanding the mutual codon usage pattern of the virus and its host(s) has fundamental and applied values.
Liyan Zeng +7 more
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Genotype-Phenotype Correlations of β-Thalassemia Mutations in an Azerbaijani Population
Turkish Journal of Hematology, 2017 β-Thalassemia is the most common inherited disorder in Azerbaijan. The aim of our study was to reveal genotype-to-phenotype correlations of the most common β-thalassemia mutations in an Azerbaijani population. Patients with codon 8 (-AA), IVS-I-
Chingiz Asadov +5 more
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The Dynamic Codon Biaser: calculating prokaryotic codon usage biases
Microbial Genomics, 2021 Bacterial genomes often reflect a bias in the usage of codons. These biases are often most notable within highly expressed genes. While deviations in codon usage can be attributed to selection or mutational biases, they can also be functional, for example controlling gene expression or guiding protein structure.
Brian Dehlinger +3 more
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Ordering events in a developing genetic code
RNA BiologyPreexisting partial genetic codes can fuse to evolve towards the complete Standard Genetic Code (SGC). Such code fusion provides a path of ‘least selection’, readily generating precursor codes that resemble the SGC.
Michael Yarus
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