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Nature, 1979 SCOPUS: ar.j ; info:eu-repo/semantics ...
Fiers, Walter, Grosjean, Henri
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Codon reassignment (codon capture) in evolution
Journal of Molecular Evolution, 1989The genetic code, once thought to be "frozen," shows variations from the universal code. Variations are found in mitochondria, Mycoplasma, and ciliated protozoa. The variations result from reassignment of codons, especially stop codons. The reassignments take place by disappearance of a codon from coding sequences, followed by its reappearance in a new
Syozo Osawa, Thomas H. Jukes
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Journal of Molecular Evolution, 1995
Schultz and Yarus (J. Mol. Biol. 235:1377-1380, 1994) have proposed that reassignment of codons in the genetic code passes through a stage in which the codons are ambiguously translated. In contrast we state that such ambiguity would be deleterious, and that, to be reassigned, a codon, together with the tRNA that translates the codon, must first ...
Thomas H. Jukes, S. Osawa
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Schultz and Yarus (J. Mol. Biol. 235:1377-1380, 1994) have proposed that reassignment of codons in the genetic code passes through a stage in which the codons are ambiguously translated. In contrast we state that such ambiguity would be deleterious, and that, to be reassigned, a codon, together with the tRNA that translates the codon, must first ...
Thomas H. Jukes, S. Osawa
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On the Probability of Codon−Codon Mutational Replacements
Journal of Chemical Information and Computer Sciences, 1997The content of the data base of blocks of protein sequences (Henikoff, S. ; Henikoff, J. G. Genomics 1994, 19, 97−107) were used in order to locate the homologous gene sequences. Aligning these sequences the 64 × 64 matrix of codon−codon interchanges was constructed. Matrices were generated for various phylogenetical groups of organisms and for various
D. Lukman +2 more
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Codon bias from minimization of codon–anticodon interaction
Biosystems, 2016Inequalities between codon usage probabilities for quartets of codons are derived using a minimum principle for codon-anticodon interaction and a probability sum rule in the framework of the Crystal Basis Model of the genetic code. Performing this study separately for the Early and for the Eukaryotic Genetic Code, we observe a consistency in the ...
Sciarrino, Antonino, Sorba, Paul
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Codon optimizer: a freeware tool for codon optimization
Protein Expression and Purification, 2003Selection plays a major role in the determination of codon usage in all organisms studied so far. In highly expressed genes, a narrow set of codons is used and these codons correspond to the more abundant tRNA species. This minimizes the risk of tRNA depletion during translation.
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Synthesis at the Speed of Codons
Trends in Biochemical Sciences, 2015The possibility that different mRNA sequences encoding identical peptides are translated dissimilarly has long been of great interest. Recent work by Yu and co-workers provides striking evidence that mRNA sequences influence the rate of protein synthesis, and lends support to the emerging idea that mRNA sequence informs protein folding.
Aditya Radhakrishnan +2 more
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Annual Review of Genetics, 2008 In a wide variety of organisms, synonymous codons are used with different frequencies, a phenomenon known as codon bias. Population genetic studies have shown that synonymous sites are under weak selection and that codon bias is maintained by a balance between selection, mutation, and genetic drift.
Dmitri A. Petrov, Ruth Hershberg
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Experientia, 1990
The analysis of coding sequences reveals nonrandomness in the context of both sense and stop codons. Part of this is related to nucleotide doublet preference, seen also in non-coding sequences and thought to arise from the dependence of mutational events on surrounding sequence.
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The analysis of coding sequences reveals nonrandomness in the context of both sense and stop codons. Part of this is related to nucleotide doublet preference, seen also in non-coding sequences and thought to arise from the dependence of mutational events on surrounding sequence.
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