Results 71 to 80 of about 616,369 (340)
Enterovirus A Shows Unique Patterns of Codon Usage Bias in Conventional Versus Unconventional Clade
Frontiers in Cellular and Infection Microbiology, 2022 Enterovirus A (EV-A) species cause hand, foot and mouth disease (HFMD), threatening the health of young children. Understanding the mutual codon usage pattern of the virus and its host(s) has fundamental and applied values.
Liyan Zeng +7 more
doaj +1 more source
Thermodynamic and kinetic insights into stop codon recognition by release factor 1. [PDF]
, 2014 Stop codon recognition is a crucial event during translation termination and is performed by class I release factors (RF1 and RF2 in bacterial cells). Recent crystal structures showed that stop codon recognition is achieved mainly through a network of ...
Joseph, Simpson +2 more
core
PhyloCSF: a comparative genomics method to distinguish protein-coding and non-coding regions [PDF]
, 2010 As high-throughput transcriptome sequencing provides evidence for novel transcripts in many species, there is a renewed need for accurate methods to classify small genomic regions as protein-coding or non-coding.
Arvestad +18 more
core +4 more sources
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
uS5/Rps2 residues at the 40S ribosome entry channel enhance initiation at suboptimal start codons in vivo [PDF]
, 2021 Jinsheng Dong, Alan G. Hinnebusch
openalex +1 more source
PLoS ONE, 2008 Most amino acids are encoded by more than one codon. These synonymous codons are not used with equal frequency: in every organism, some codons are used more commonly, while others are more rare. Though the encoded protein sequence is identical, selective pressures favor more common codons for enhanced translation speed and fidelity.
Thomas F Clarke, Patricia L Clark
openaire +4 more sources
Unexpected correlations between gene expression and codon usage bias from microarray data for the whole Escherichia coli K-12 genome [PDF]
, 2003 Escherichia coli has long been regarded as a model organism in the study of codon usage bias (CUB). However, most studies in this organism regarding this topic have been computational or, when experimental, restricted to small datasets; particularly poor
dos Reis, M. +2 more
core +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Cloning and analysis of genome of transmissible gastroenteritis virus SC-Y strain
浙江大学学报. 农业与生命科学版, 2007 Sixteen pair of primers covering the whole genome of TGEV were devised according to the published sequences, 16 cDNA fragments were amplified by RT-PCR. The amplified fragments were further cloned and sequenced. The genome of SC-Y strain was assembled by
SONG Zhen-hui, GUO Wan-zhu, YIN Hua-ping
doaj +1 more source