Results 101 to 110 of about 1,577,940 (309)

Identifying Novel Inhibitors of RpFabG in Typhus-inducing Rickettsia prowazekii [PDF]

, 2019
Epidemic typhus is a rickettsial disease that is contracted via ticks and lice found on the flying squirrel. The disease is caused by Rickettsia prowazekii, an intracellular, gram-negative coccobacillus.
Panatpur, Aparna
core   +1 more source

Coenzyme Q deficiency in muscle

Current Opinion in Neurology, 2011
Coenzyme Q (CoQ) is a vital component of the mitochondrial respiratory chain. A number of patients with CoQ deficiency presented with different clinical phenotypes, often affecting skeletal muscle, and responded well to CoQ supplementation. We discuss recent advances in this field with special attention to muscle involvement.The identification of ...
TREVISSON, EVA, Salvatore DiMauro, Placido Navas, SALVIATI, LEONARDO   +3 more
openaire   +4 more sources

Cascade Therapy of Periodontitis via Sequential Release of Ribosome‐Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF‐Based System

Advanced Science, EarlyView.
This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen, Zheng Xu, Yunmo Xue, Shanshan Liu, Xiang Zhang, Jingyao Guo, Minhui Yao, Yue Liu, Xiaolin Lu, Jieshu Qian, Qian Ma   +10 more
wiley   +1 more source

Human COQ10A and COQ10B are distinct lipid-binding START domain proteins required for coenzyme Q function[S]

Journal of Lipid Research, 2019
Coenzyme Q (CoQ or ubiquinone) serves as an essential redox-active lipid in respiratory electron and proton transport during cellular energy metabolism.
H. Tsui, Nguyen V. B. Pham, Brendan R. Amer, M. Bradley, Jason E. Gosschalk, M. Gallagher-Jones, Hope Ibarra, R. Clubb, Crysten E. Blaby-Haas, C. Clarke   +9 more
semanticscholar   +1 more source

The Age‐Dependent Resident Myonuclear Multi‐Omic Response to an Acute Skeletal Muscle Hypertrophic Stimulus in Mice

Advanced Science, EarlyView.
Resident myonuclei are the molecular “control centers” for large multinuclear muscle fibers. It is presumed that, with aging, these control centers become compromised and contribute to delayed or blunted muscle adaptive potential. This study is a detailed roadmap that exposes how young versus aged myonuclei respond to a hypertrophic loading stimulus ...
Pieter J. Koopmans, Ronald G. Jones III, Ana Regina Cabrera, Francielly Morena, Nicholas P. Greene, John J. McCarthy, Ahmed Ismaeel, Yuan Wen, Kevin A. Murach   +8 more
wiley   +1 more source

Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice [PDF]

, 2017
Background: The phosphorylation of eukaryotic initiation factor 2 (p-eIF2) during dietary amino acid insufficiency reduces protein synthesis and alters gene expression via the integrated stress response (ISR).Objective: We explored whether a Met ...
Anthony, Tracy G., Bargoud, Albert R., Gettys, Thomas W., Hamilton, Karyn L., Jonsson, William O., Kimball, Scot R., Miller, Benjamin F., Mirek, Emily T., Peelor, Frederick F., III, Pettit, Ashley P., Wang, Yongping, Wek, Ronald C.   +11 more
core   +1 more source

An Isoprene Lipid-Binding Protein Promotes Eukaryotic Coenzyme Q Biosynthesis.

Molecules and Cells, 2019
The biosynthesis of coenzyme Q presents a paradigm for how cells surmount hydrophobic barriers in lipid biology. In eukaryotes, CoQ precursors-among nature's most hydrophobic molecules-must somehow be presented to a series of enzymes peripherally ...
Danielle C. Lohman, D. Aydin, Helaina Von Bank, Robert W. Smith, V. Linke, Erin Weisenhorn, Molly T. McDevitt, Paul D Hutchins, Emily M. Wilkerson, Benjamin Wancewicz, J. Russell, Matthew S. Stefely, E. T. Beebe, Adam Jochem, J. Coon, C. Bingman, M. dal Peraro, D. Pagliarini   +17 more
semanticscholar   +1 more source

Systematic Engineering of Proteases in Saccharopolyspora Spinosa Reveals Synergistic Enhancement of Spinosad Biosynthesis via Substrate Flux Optimization

Advanced Science, EarlyView.
ARTP mutagenesis yielded Saccharopolyspora spinosa mutant D184 with improved extracellular nitrogen utilization. An integrated workflow of protease genetic manipulation, multi‐omics, and rational synergy design pinpointed a pepP‐clpP‐htpX synergistic triangular combination.
Duo Jin, Wangqiong Chen, Danlu Yang, Qing Liu, Baolong Bai, Zirui Dai, Xirong Liu, Zirong Zhu, Jie Rang, Liqiu Xia   +9 more
wiley   +1 more source

Antioxidantes dietéticos para la prevención de la periodontitis crónica y su tratamiento. Una revisión de las evidencias actuales procedentes de estudios en animales y humanos [PDF]

, 2015
Objetivos. Dada la relación existente entre periodontitis crónica y altos niveles de estrés oxidativo, esta revisión pretende clarificar qué papel puede desempeñar la ingesta de los diferentes antioxidantes de la dieta en el mantenimiento de un ...
Bullon, Pedro
core  

A novel class of CoA-transferase involved in short-chain fatty acid metabolism in butyrate-producing human colonic bacteria [PDF]

, 2005
Peer reviewedPublisher ...
Altschul, Asanuma, Ausubel, Barcenilla, Barker, Bennett, Blaut, Boynton, Buckel, Cleland, Cédric Charrier, Diez-Gonzalez, Donna Henderson, Duncan, Ewing, Ewing, Fischer, Garry J. Rucklidge, Gary J. Duncan, Gerhardt, Gordon, Harry J. Flint, Heider, Louis, Macfarlane, Mack, Martin D. Reid, Miller, Ochman, Pauline Young, Perkins, Petra Louis, Pryde, Rincon, Rustam I. Aminov, Scherf, Schweiger, Selmer, Skantar, Smith, Söhling, Sramek, Tung, Valentin, Valerie J. Russell, Walter, Wächtershäuser, Wiesenborn, Wilkins   +48 more
core   +1 more source