Results 111 to 120 of about 1,766,693 (250)

Antioxidant Function of Coenzyme Q

Journal of Nutritional Science and Vitaminology, 1992
Evidence for in vivo antioxidative activity of reduced CoQ homologs has been presented. This came from studies with experimental endotoxemia in mice, reoxygenation of rat liver following ischemia, and reoxygenation of canine heart following 24-hour cold preservation.
openaire   +3 more sources

Gastritis and age‐related macular degeneration: Potential roles of metabolomic dysregulation and photoreceptor alterations

VIEW, EarlyView.
Abstract Age‐related macular degeneration (AMD) is a degenerative retinal disorder and a leading cause of global visual impairment, yet effective treatments remain limited. While gastritis is a prevalent clinical condition among older populations and has been associated with adverse effects on the central nervous system, its potential association with ...
Jingxin Zhou, Jiawei Wang, Yingcheng He, Jing Cao, Jiayu Duan, Juan Ye   +5 more
wiley   +1 more source

TcALS knockdown accelerates metamorphosis via insulin signaling in Tribolium castaneum

Insect Science, EarlyView.
RNAi silencing of TcALS accelerates larva‐to‐pupa metamorphosis in Tribolium castaneum. Abstract Insect metamorphosis is an evolutionary adaptation precisely regulated by nutritional and hormonal cues. The red flour beetle Tribolium castaneum, a major stored‐product pest, serves as an excellent model for studying this process.
Min Li, Jie Chen, Zi‐Ye Wang, Fei‐Feng Wang, Lu‐Lu Dong, Jun Pan, Min‐Er Li, Lin Yu, Wen Sang   +8 more
wiley   +1 more source

A horizontally acquired pantothenate gene drives vitellogenin's benefit to whitefly symbiosis persistence

Insect Science, EarlyView.
This diagram illustrates that the horizontally transferred panBC influences the level and localization of vitellogenin (Vg) by facilitating pantothenate production and juvenile hormone (JH) biosynthesis. In turn, Vg shields symbionts by suppressing autophagic degradation in bacteriocytes.
Xiang Sun, Bing‐Qi Liu, Zhan‐Bo Chen, Chu‐Qiao Li, Xing‐Ye Li, Jun‐Bo Luan   +5 more
wiley   +1 more source

Serum CD5L Responds Positively to Selenium and Coenzyme Q₁₀ Supplementation with Relation to Thyroid Hormones, Mortality, and Health-Related Quality-of-Life—A Sub-Analysis of a Double-Blind Randomised Placebo-Controlled Trial in Elderly Low in Selenium

Antioxidants
The Cluster of Differentiation 5-like protein (CD5L) is produced by tissue-resident macrophages. It is an innate immune mediator protein with a multitude of functions, such as binding of invading microorganisms and oxidised LDL, and it is associated with
Urban Alehagen, Jan O. Aaseth, Trine B. Opstad, Anders Larsson, Sabrina Asaad, Lutz Schomburg, Jan Alexander   +6 more
doaj   +1 more source

The Endoplasmic Reticulum-Mitochondria Encounter Structure Complex Coordinates Coenzyme Q Biosynthesis

Contact, 2019
Loss of the endoplasmic reticulum (ER)-mitochondria encounter structure (ERMES) complex that resides in contact sites between the yeast ER and mitochondria leads to impaired respiration; however, the reason for that is not clear.
Michal Eisenberg-Bord, Hui S. Tsui, Diana Antunes, Lucía Fernández-del-Río, Michelle C. Bradley, Cory D. Dunn, Theresa P. T. Nguyen, Doron Rapaport, Catherine F. Clarke, Maya Schuldiner   +9 more
doaj   +1 more source

A horizontally transferred bacterial gene for pantothenic acid biosynthesis regulates diapause and reproduction in the spider mite Amphitetranychus viennensis

Insect Science, EarlyView.
A bacterial‐derived AvPBL gene encoding a pantothenate‐β‐alanine ligase was identified in Amphitetranychus viennensis. RNAi silencing of AvPBL reduced pantothenic acid production, impairing reproduction and diapause induction, while pantothenic acid supplementation rescued these phenotypes.
Meibin Liu, Yifei Wang, Yikang Ren, Fan Yang, Meifeng Ren, Qin Yu, Xuguo Zhou, Zezhong Yang, Jing Yang   +8 more
wiley   +1 more source

Coenzyme Q deficiency causes impairment of the sulfide oxidation pathway

EMBO Molecular Medicine, 2016
Coenzyme Q (CoQ) is an electron acceptor for sulfide‐quinone reductase (SQR), the first enzyme of the hydrogen sulfide oxidation pathway. Here, we show that lack of CoQ in human skin fibroblasts causes impairment of hydrogen sulfide oxidation ...
Marcello Ziosi, Ivano Di Meo, Giulio Kleiner, Xing‐Huang Gao, Emanuele Barca, Maria J Sanchez‐Quintero, Saba Tadesse, Hongfeng Jiang, Changhong Qiao, Richard J Rodenburg, Emmanuel Scalais, Markus Schuelke, Belinda Willard, Maria Hatzoglou, Valeria Tiranti, Catarina M Quinzii   +15 more
doaj   +1 more source

L-2-hydroxyglutarate recycling is linked to coenzyme Q biosynthesis

The mitochondrial COQ metabolon catalyzes the late stages of the biosynthesis of coenzyme Q, an essential and ubiquitous cofactor. Here, by integrating coevolution, coexpression, colocalization and domain-fusion analyses, we identify L-2-hydroxyglutarate
Andrea Alfieri, Callum Robert Nicoll, Andrea Gottinger, Felix Distelmaier, Demetra Mattiroli, Marco Malatesta, Diran Herebian, Annette Seibt, Andrea Mattevi, Domiziana Cecchini   +9 more
core   +1 more source

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source