Results 61 to 70 of about 3,143,453 (309)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Affective and Cognitive Information Behavior: Interaction Effects in Internet Use [PDF]

, 2005
The presence and influence of affective variables in information behavior was studied. Affective load (AL), a compound variable consisting of uncertainty and technophobia measures, was found to be present in a variety of simple and complex information ...
Nahl, Diane
core   +1 more source

A Comparative Study on Feature Extraction Techniques for the Discrimination of Frontotemporal Dementia and Alzheimer’s Disease with Electroencephalography in Resting-State Adults

Brain Sciences
Early-stage Alzheimer’s disease (AD) and frontotemporal dementia (FTD) share similar symptoms, complicating their diagnosis and the development of specific treatment strategies.
Utkarsh Lal, Arjun Vinayak Chikkankod, Luca Longo   +2 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Apolipoprotein E genotype does not moderate the associations of depressive symptoms, neuroticism and allostatic load with cognitive ability and cognitive aging in the Lothian Birth Cohort 1936. [PDF]

PLoS ONE, 2018
In this replication-and-extension study, we tested whether depressive symptoms, neuroticism, and allostatic load (multisystem physiological dysregulation) were related to lower baseline cognitive ability and greater subsequent cognitive decline in older ...
Zander Crook, Tom Booth, Simon R Cox, Janie Corley, Dominika Dykiert, Paul Redmond, Alison Pattie, Adele M Taylor, Sarah E Harris, John M Starr, Ian J Deary   +10 more
doaj   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

High school students’ cognitive load on biology learning: A case study

Assimilation
This study aimed to analyze the cognitive load of high school students on biology learning. The method was used in this research is the survey method. The subjects of the study consisted of 179 students in grade X students consisting of 56 male students ...
Aris Sunandar, Rina Karwatisari, Adi Rahmat, Nanang Winarno, Yanti Hamdiyati   +4 more
doaj   +1 more source

A systematized review of cognitive load theory in health sciences education and a perspective from cognitive neuroscience

Journal of Education and Health Promotion, 2020
INTRODUCTION: To design instructions in health sciences education, it is highly relevant to heed the working memory and the approaches for managing cognitive load.
Sahar Ghanbari, Fariba Haghani, Majid Barekatain, Alireza Jamali   +3 more
doaj   +1 more source

Assessment of cognitive load in the context of neurosurgery [PDF]

International Journal of Computer Assisted Radiology and Surgery
Image-guided neurosurgery demands precise depth perception to minimize cognitive burden during intricate navigational tasks. Existing evaluation methods rely heavily on subjective user feedback, which can be biased and inconsistent. This study uses a physiological measure via electroencephalography (EEG), to quantify cognitive load when using novel ...
Daniel Di Giovanni, Marta Kersten-Oertel, Simon Drouin, D. Louis Collins   +3 more
openaire   +4 more sources

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source