Results 81 to 90 of about 8,259,301 (296)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The Predictive Role of Community of Inquiry in Shaping Students' Creative Self‐Concept: A Cross‐Sectional Study

open access: yesNursing Open
Background Creative self‐concept is essential for nursing students as it supports innovation, adaptability and problem‐solving in clinical practice. The community of inquiry framework offers a model for promoting reflective and meaningful learning.
Shaherah Yousef Andargeery   +10 more
doaj   +1 more source

Presence and Prediction: The Embodied Reader's Cascades of Cognition

open access: yesStyle, 2014
Abstract What would a model of the embodied reader look like? Is he tied to the embodied resonances evoked by the text and by extension grounded in the here and now of the represented situation? Or can we integrate the dynamics of the plot in his reading experience? Can the embodied reader take a metaperspective, deciding whether what
openaire   +3 more sources

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

International Online Graduate Students’ Perceptions of CoI

open access: yesEURODL, 2020
With the current issue of student retention and attrition as a major aspect of online education, this interpretivist qualitative case study sought to determine whether online facilitators and online student-to-student relationships affect online graduate
Charmaine Bissessar   +2 more
doaj   +1 more source

Cognitive Presence in a Blended Learning Environment at Jordanian Universities

open access: yesArab World English Journal, 2020
Cognitive presence is the ability of the learners to project their mental and perceptual presence. This paper aims to investigate cognitive presence when using a Blended Learning environment.
Jibrel Harb, Pramela Krish
semanticscholar   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

What if online students take on the responsibility: Students’ cognitive presence and peer facilitation techniques

open access: yesOnline Learning, 2019
The purpose of this study was to investigate: (a) the characteristics of online students’ cognitive presence in a peer-facilitated discussion environment, and (b) the peer facilitation techniques that enhance cognitive presence development. In this study,
Ye Chen, Jing Lei, Jiaming Cheng
semanticscholar   +1 more source

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