Results 21 to 30 of about 334,109 (235)

Morusin inhibits the growth of human colorectal cancer HCT116‑derived sphere‑forming cells via the inactivation of Akt pathway. [PDF]

Int J Mol Med, 2021
The existence of colorectal cancer stem-like cells (CSC) is responsible for the failure of current treatments against colorectal cancer. Therefore, novel therapies need be developed to target CSCs.
Zhou Y, Li X, Ye M.
europepmc   +2 more sources

NEDD9 promotes invasion and migration of colorectal cancer cell line HCT116 via JNK/EMT

Oncology Letters, 2019
Neural precursor cell-expressed, developmentally-downregulated 9 (NEDD9) is a multi-domain skeleton protein that serves an important role in the cell signaling process via modulating invasion, metastasis, proliferation and apoptosis of tumor cells.
Meng, Haining, Wu, Junyu, Huang, Qiao, Yang, Xi, Yang, Kunao, Qiu, Yuexin, Ren, Jiwen, Shen, Ruowu, Qi, Hong   +8 more
openaire   +4 more sources

Effects of histone deacetylase inhibitors on ATP-binding cassette transporters in lung cancer A549 and colorectal cancer HCT116 cells. [PDF]

Oncol Lett, 2019
Histone deacetylase (HDAC) inhibitors and DNA alkylators are effective components used in combination chemotherapy. In the present study, the effects of HDAC inhibitors on the expression of ATP-binding cassette (ABC) transporters were investigated.
Wang H, Chi CH, Zhang Y, Shi B, Jia R, Wang BJ.   +5 more
europepmc   +2 more sources

Effect of sodium butyrate on ABC transporters in lung cancer A549 and colorectal cancer HCT116 cells. [PDF]

Oncol Lett, 2020
Histone deacetylase (HDAC) inhibitors and DNA alkylators are effective components of combination chemotherapy. The aim of the present study was to investigate the possible mechanism of their synergism by detecting the effect of HDAC inhibitors on the expression levels of drug transporters that export DNA alkylators.
Shi B, Xu FF, Xiang CP, Jia R, Yan CH, Ma SQ, Wang N, Wang AJ, Fan P.   +8 more
europepmc   +4 more sources

The dietary flavone luteolin epigenetically activates the Nrf2 pathway and blocks cell transformation in human colorectal cancer HCT116 cells. [PDF]

J Cell Biochem, 2018
Colorectal cancer remains a leading malignancy in humans. The importance of epigenetic modification in the development of this disease is now being recognized. The reversible and dynamic nature of epigenetic modifications provides a promising strategy in
Zuo Q, Wu R, Xiao X, Yang C, Yang Y, Wang C, Lin L, Kong AN.   +7 more
europepmc   +2 more sources

Antiproliferative effect of new chalcone derivatives in human colorectal cancer HCT116 cells

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2018
Gabriela Mojzisova, Peter Takac, Zuzana Kudlickova, Maria Vilkova, Martina Pilatova, Martin Kello, Ladislav Mirossay, Jan Mojzis   +7 more
openaire   +3 more sources

A zebrafish HCT116 xenograft model to predict anandamide outcomes on colorectal cancer

Cell Death & Disease, 2022
AbstractColon cancer is one of the leading causes of death worldwide. In recent years, cannabinoids have been extensively studied for their potential anticancer effects and symptom management. Several in vitro studies reported anandamide’s (AEA) ability to block cancer cell proliferation and migration, but evidence from in vivo studies is still lacking.
Francesca Maradonna, Camilla M. Fontana, Fiorenza Sella, Christian Giommi, Nicola Facchinello, Chiara Rampazzo, Micol Caichiolo, Seyed Hossein Hoseinifar, Luisa Dalla Valle, Hien Van Doan, Oliana Carnevali   +10 more
openaire   +6 more sources

Deactivation of CK1α enhances the anti-cancer effects of salinomycin in colorectal cancer HCT116 cells. [PDF]

Biochem Biophys Rep
Khakshournia S, Siri M, Zamani M, Bozorg-Ghalati F, Mojtahedi Z, Igder S, Azarpira N, Mokarram P.   +7 more
europepmc   +2 more sources

Generation of a cancer testis antigen mCherry reporter HCT116 colorectal carcinoma cell line [PDF]

Heliyon, 2018
In the context of cancer immunotherapy, agents that target the immune system to cancer cells need to fulfil two criteria: 1) that they are only expressed on the desired target cell and 2) that they can elicit a potent immunological response. Cancer Testis Antigens are a large disparate family of factors ordinarily expressed in the germ-line but ...
Jyoti B. Chhetri, Elena Drousioti, José Afonso Guerra-Assunção, Javier Herrero, Steen K.T. Ooi   +4 more
openaire   +4 more sources

MicroRNA miR-425 inhibits proliferation and migration of colorectal cancer HCT116 cells.

JPMA. The Journal of the Pakistan Medical Association, 2021
Objective To assess the role of micro ribonucleic acid 425 in colorectal carcinogenesis. METHODS The experimental study was conducted from December 2016 to July 2017 at the Xinjiang Dingju Medical Laboratory, China, and comprised sphere formation assay,
Huifang Zhou, Wen Liu, Haiyun Chen, Jiajia Ni, Zhi Zhang, Aimin Xu   +5 more
semanticscholar   +1 more source