Results 31 to 40 of about 334,109 (235)

Expression of γ-synuclein in colorectal cancer tissues and its role on colorectal cancer cell line HCT116

World Journal of Gastroenterology, 2009
To investigate the expression pattern of gamma-synuclein in colorectal cancer (CRC) tissues, and to study the effects of gamma-synuclein on CRC cell line HCT116 biological features in vitro.The expression pattern of gamma-synuclein was determined in 54 CRC tissues and 30 tumor-matched nonneoplastic adjacent tissues (NNAT) 5 cm away from the tumor via ...
Qing, Ye, Bo, Feng, Yuan-Fei, Peng, Xue-Hua, Chen, Qu, Cai, Bei-Qin, Yu, Liang-Hui, Li, Ming-Yuan, Qiu, Bing-Ya, Liu, Min-Hua, Zheng   +9 more
openaire   +2 more sources

β‐Ketoiminato Iridium(III) Organometallic Complexes: Selective Cytotoxicity towards Colorectal Cancer Cells HCT116 p53‐/‐ [PDF]

Chemistry – A European Journal, 2018
AbstractThis report presents a new library of organometallic iridium(III) compounds of the type [Cp*IrCl(L)] (Cp*=pentamethylcyclopentadienyl and L=a functionalized β‐ketoiminato ligand) showing moderate to high cytotoxicity against a range of cancer cell lines. All compounds show increased activity towards colorectal cancer, with preferential activity
Rianne M. Lord, Markus Zegke, Imogen R. Henderson, Christopher M. Pask, Helena J. Shepherd, Patrick C. McGowan   +5 more
openaire   +4 more sources

Intra-tumoral heterogeneity in metastatic potential and survival signaling between iso-clonal HCT116 and HCT116b human colon carcinoma cell lines. [PDF]

PLoS ONE, 2013
Colorectal cancer (CRC) metastasis is a leading cause of cancer-related deaths in the United States. The molecular mechanisms underlying this complex, multi-step pathway are yet to be completely elucidated.
Sanjib Chowdhury, Melanie Ongchin, Elizabeth Sharratt, Ivan Dominguez, Jing Wang, Michael G Brattain, Ashwani Rajput   +6 more
doaj   +1 more source

Discovery of second generation heat shock protein 110 (HSP110) inhibitors for potential treatment of colorectal cancer

European Journal of Medicinal Chemistry Reports, 2023
Heat shock protein 110 (HSP110) is an emerging biological target for development of drug to treat colorectal cancer. In the present study, we designed and synthesized a series of novel small-molecule inhibitors of HSP110 based on previously reported ...
Li Xu, Yuan Wang, Xingrui He, Yuan Gao, Frédéric Lirussi, Yi Zhou, Carmen Garrido, Hang Zhang, Tian Xie, Xiang-Yang Ye   +9 more
doaj   +1 more source

Efficacy of the MEK Inhibitor Cobimetinib and its Potential Application to Colorectal Cancer Cells

Cellular Physiology and Biochemistry, 2018
Background/Aims: Mutations in the Ras/Raf/MEK/ERK pathway are detected in 50% of colorectal cancer cases and play a crucial role in cancer development and progression.
Shu Gong, Dongsheng Xu, Jialin Zhu, Fangdong Zou, Rui Peng   +4 more
doaj   +1 more source

Butyrate inhibits the proliferation and induces the apoptosis of colorectal cancer HCT116 cells via the deactivation of mTOR/S6K1 signaling mediated partly by SIRT1 downregulation.

Molecular Medicine Reports, 2019
Butyrate, a histone deacetylase inhibitor, is a typical short chain fatty acid produced by gut microbiota, the dysmetabolism of which has been consistently associated with colorectal diseases.
M. Cao, Zhuoran Zhang, Su Han, Xi Lu
semanticscholar   +1 more source

Hybrid liposomes showing enhanced accumulation in tumors as theranostic agents in the orthotopic graft model mouse of colorectal cancer

Drug Delivery, 2018
Hybrid liposomes (HLs) can be prepared by simply sonicating a mixture of vesicular and micellar molecules in a buffer solution. This study aimed to elucidate the therapeutic effects and ability of HLs to detect (diagnosis) cancer in an orthotopic graft ...
Masaki Okumura, Hideaki Ichihara, Yoko Matsumoto   +2 more
doaj   +1 more source

Ginsenoside Rh2 inhibiting HCT116 colon cancer cell proliferation through blocking PDZ-binding kinase/T-LAK cell-originated protein kinase

Journal of Ginseng Research, 2016
Background: Ginsenoside Rh2 (GRh2) is the main bioactive component in American ginseng, a commonly used herb, and its antitumor activity had been studied in previous studies.
Jianjun Yang, Donghong Yuan, Tongchao Xing, Hongli Su, Shengjun Zhang, Jiansheng Wen, Qiqiang Bai, Dongmei Dang   +7 more
doaj   +1 more source

8-Cl-Adenosine-Induced Inhibition of Colorectal Cancer Growth In Vitro and In Vivo

Neoplasia: An International Journal for Oncology Research, 2000
The cAMP analogue 8-Cl-cAMP induces apoptosis and inhibits proliferation of a wide variety of malignancies in vitro and in vivo with relatively little toxicity.
Chris C. Carlson, Rebecca Chinery, Laura L. Burnham, Daniel T. Dransfield   +3 more
doaj   +1 more source

Elevated basal AMP-activated protein kinase activity sensitizes colorectal cancer cells to growth inhibition by metformin

Open Biology, 2023
Expression and activity of the AMP-activated protein kinase (AMPK) α1 catalytic subunit of the heterotrimeric kinase significantly correlates with poor outcome for colorectal cancer patients.
Kaitlin R. Morrison, Tingting Wang, Kuan Yoow Chan, Eleanor W. Trotter, Ari Gillespie, Michael Z. Michael, Jonathan S. Oakhill, Iain M. Hagan, Janni Petersen   +8 more
doaj   +1 more source