Results 41 to 50 of about 334,109 (235)

Potential Application of Eicosapentaenoic Acid Monoacylglyceride in the Management of Colorectal Cancer

Marine Drugs, 2017
Background: There is increasing evidence that marine omega-3 oils are involved in the reduction of cancer risk and progression. However, the anticancer effect of omega-3 monoglyceride on colorectal cancer has yet to be assessed.
Caroline Morin, Enrique Rodríguez, Pierre U. Blier, Samuel Fortin   +3 more
doaj   +1 more source

Tetrandrine Inhibits Epithelial-Mesenchymal Transition in IL-6-Induced HCT116 Human Colorectal Cancer Cells

OncoTargets and Therapy, 2021
Patients with colorectal cancer (CRC) often develop distant metastases, which significantly reduces the 5-year survival rate. Epithelial-mesenchymal transition (EMT) is a crucial process for the invasion and metastasis of cancer cells. Tetrandrine has been reported to inhibit the viability and EMT of CRC cells; however, to the best of our knowledge ...
Shih-Chang Tsai, Wei-Che Wu, Jai-Sing Yang   +2 more
openaire   +4 more sources

Downregulation of caveolin-1 increases the sensitivity of drug-resistant colorectal cancer HCT116 cells to 5-fluorouracil.

Oncology Letters, 2017
Colorectal cancer is the third most common type of cancer in men and women. Chemotherapy is an important treatment strategy for patients with terminal stage cancer.
Z. Li, Ning Wang, Changxin Huang, Yanhong Bao, Yiqian Jiang, Guiting Zhu   +5 more
semanticscholar   +1 more source

Activation of WNT7b autocrine eases metastasis of colorectal cancer via epithelial to mesenchymal transition and predicts poor prognosis

BMC Cancer, 2021
Background Aberrant activation of the Wnt/β-catenin signaling pathway is one of the most frequent abnormalities in human cancer, including colorectal cancer (CRC). Previous studies revealed pivotal functions of WNT family members in colorectal cancer, as
Shuai Jiang, Qiwen Li, Yimin Liu, Huimin Zhang, Qianyu Wang, Yu Chen, Xiaoyang Shi, Jun Li, Hailing Zhang, Yi Zhang, Dongqing Xia, Man Wu, Jiajia Lin, Chenglin Zhang, Suhua Pang, Jiamin Jiang, Yan Wen, Peipei Zhang   +17 more
doaj   +1 more source

Mechanistic study on Tricellulin regulation of colorectal cancer cell invasion, metastasis and epithelial-mesenchymal transition

结直肠肛门外科
[Objectives] To investigate the related molecular mechanisms by which Tricellulin regulates the invasion, migration and metastasis and epithelial-mesenchymal transition (EMT) progression in colorectal cancer. [Methods] Tissue specimens from 40 colorectal
Yang Wenfang, Liao Cun, Zhang Jinxiu, Cheng Ruoxi, Pan Xiaoping, Chen Qiuling, Tan Yanlin, Feng Kaoyan, Qin Mengbin, Huang Jie’an   +9 more
doaj   +1 more source

N-Heterocyclic Carbene Iron Complexes as Anticancer Agents: In Vitro and In Vivo Biological Studies

Molecules, 2021
Cisplatin and its derivatives are commonly used in chemotherapeutic treatments of cancer, even though they suffer from many toxic side effects. The problems that emerge from the use of these metal compounds led to the search for new complexes capable to ...
Oscar A. Lenis-Rojas, Sandra Cordeiro, Marta Horta-Meireles, Jhonathan Angel Araujo Fernández, Sabela Fernández Vila, Juan Andrés Rubiolo, Pablo Cabezas-Sainz, Laura Sanchez, Alexandra R. Fernandes, Beatriz Royo   +9 more
doaj   +1 more source

Induction of apoptosis in human colorectal cancer cells by nanovesicles from fingerroot (Boesenbergia rotunda (L.) Mansf.).

PLoS ONE, 2022
Colorectal cancer is the leading cause of cancer-related deaths worldwide, warranting the urgent need for a new treatment option. Plant-derived nanovesicles containing bioactive compounds represent new therapeutic avenues due to their unique ...
Saharut Wongkaewkhiaw, Amaraporn Wongrakpanich, Sucheewin Krobthong, Witchuda Saengsawang, Arthit Chairoungdua, Nittaya Boonmuen   +5 more
doaj   +1 more source

Promotion of colorectal cancer by transcription factor BHLHE40 involves upregulation of ADAM19 and KLF7

Frontiers in Oncology, 2023
BHLHE40 is a transcription factor, whose role in colorectal cancer has remained elusive. We demonstrate that the BHLHE40 gene is upregulated in colorectal tumors.
Yuan Sui, Hanlin Jiang, Collyn M. Kellogg, Sangphil Oh, Sangphil Oh, Ralf Janknecht, Ralf Janknecht, Ralf Janknecht   +7 more
doaj   +1 more source

Curcumin- and Piperine-Loaded Emulsomes as Combinational Treatment Approach Enhance the Anticancer Activity of Curcumin on HCT116 Colorectal Cancer Model

Frontiers in Bioengineering and Biotechnology, 2020
Combination chemotherapy, administrating two chemotherapeutic agents concurrently, comes into prominence, as the heterogeneity or the level of the disease necessitates a collaborative action.
Zeynep Busra Bolat, Zeynep Islek, Bilun Nas Demir, E. Yilmaz, F. Şahin, M. H. Ucisik   +5 more
semanticscholar   +1 more source

Long Non-Coding RNA CKMT2-AS1 Reduces the Viability of Colorectal Cancer Cells by Targeting AKT/mTOR Signaling Pathway

Iranian Journal of Public Health, 2022
Background: Colorectal cancer (CRC) has not only seriously affected people’s lives, but also burdened the government healthcare system. Long non-coding RNAs (lncRNA) have attracted more and more attention in the cancer study field.
Biao Zhuang, Xiong Ni, Zhijun Min, Dejun Wu, Tingfeng Wang, Peng Cui   +5 more
doaj